Catechin gallates inhibit multidrug resistance (MDR) in Staphylococcus aureus
Abstract Epicatechin gallate (1) and epigallocatechin gallate (2) were evaluated for their antibacterial and efflux inhibitory activity against a wild-type and three multidrug-resistant (MDR) strains of STAPHYLOCOCCUS AUREUS. Compound 2 was more active than 1 based on minimum inhibitory concentratio...
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| Veröffentlicht in: | Planta medica 2004-12, Vol.70 (12), p.1240-1242 |
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| container_title | Planta medica |
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| creator | Gibbons, S Moser, E Kaatz, G.W |
| description | Abstract
Epicatechin gallate (1) and epigallocatechin gallate (2) were evaluated for their antibacterial and efflux inhibitory activity against a wild-type and three multidrug-resistant (MDR) strains of STAPHYLOCOCCUS AUREUS. Compound 2 was more active than 1 based on minimum inhibitory concentrations (MICs; 32 - 64 versus 64 - > 512 μg/mL, respectively). When incorporated into the growth medium at 20 μg/mL, both compounds exhibited a four-fold potentiation of the activity of norfloxacin against a norfloxacin-resistant strain of S. AUREUS overexpressing the NorA multidrug efflux pump. Against this strain 1 was moderately more potent than 2 as an inhibitor of ethidium efflux, but at ≤ 20 μM both compounds paradoxically stimulated efflux. This phenomenon has not been encountered previously in the analysis of inhibitors of multidrug efflux. |
| doi_str_mv | 10.1055/s-2004-835860 |
| format | Article |
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Epicatechin gallate (1) and epigallocatechin gallate (2) were evaluated for their antibacterial and efflux inhibitory activity against a wild-type and three multidrug-resistant (MDR) strains of STAPHYLOCOCCUS AUREUS. Compound 2 was more active than 1 based on minimum inhibitory concentrations (MICs; 32 - 64 versus 64 - > 512 μg/mL, respectively). When incorporated into the growth medium at 20 μg/mL, both compounds exhibited a four-fold potentiation of the activity of norfloxacin against a norfloxacin-resistant strain of S. AUREUS overexpressing the NorA multidrug efflux pump. Against this strain 1 was moderately more potent than 2 as an inhibitor of ethidium efflux, but at ≤ 20 μM both compounds paradoxically stimulated efflux. This phenomenon has not been encountered previously in the analysis of inhibitors of multidrug efflux.</description><identifier>ISSN: 0032-0943</identifier><identifier>EISSN: 1439-0221</identifier><identifier>DOI: 10.1055/s-2004-835860</identifier><identifier>PMID: 15643566</identifier><identifier>CODEN: PLMEAA</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - therapeutic use ; antibacterial properties ; Biological and medical sciences ; catechin ; Catechin - administration & dosage ; Catechin - analogs & derivatives ; Catechin - pharmacology ; Catechin - therapeutic use ; chemical structure ; Drug Resistance, Multiple ; epicatechin ; epigallocatechin ; General pharmacology ; Humans ; Letter ; Medical sciences ; Microbial Sensitivity Tests ; multiple drug resistance ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phytotherapy ; Plants, Medicinal ; Staphylococcus aureus ; Staphylococcus aureus - drug effects</subject><ispartof>Planta medica, 2004-12, Vol.70 (12), p.1240-1242</ispartof><rights>Georg Thieme Verlag KG Stuttgart · New York</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-211f30738ed749aeb623e638752cb034b6399dda8548491ec778fe1ca33172753</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2004-835860.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2004-835860$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,780,784,3017,3018,27924,27925,54559,54560</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16385139$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15643566$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gibbons, S</creatorcontrib><creatorcontrib>Moser, E</creatorcontrib><creatorcontrib>Kaatz, G.W</creatorcontrib><title>Catechin gallates inhibit multidrug resistance (MDR) in Staphylococcus aureus</title><title>Planta medica</title><addtitle>Planta Med</addtitle><description>Abstract
Epicatechin gallate (1) and epigallocatechin gallate (2) were evaluated for their antibacterial and efflux inhibitory activity against a wild-type and three multidrug-resistant (MDR) strains of STAPHYLOCOCCUS AUREUS. Compound 2 was more active than 1 based on minimum inhibitory concentrations (MICs; 32 - 64 versus 64 - > 512 μg/mL, respectively). When incorporated into the growth medium at 20 μg/mL, both compounds exhibited a four-fold potentiation of the activity of norfloxacin against a norfloxacin-resistant strain of S. AUREUS overexpressing the NorA multidrug efflux pump. Against this strain 1 was moderately more potent than 2 as an inhibitor of ethidium efflux, but at ≤ 20 μM both compounds paradoxically stimulated efflux. This phenomenon has not been encountered previously in the analysis of inhibitors of multidrug efflux.</description><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>antibacterial properties</subject><subject>Biological and medical sciences</subject><subject>catechin</subject><subject>Catechin - administration & dosage</subject><subject>Catechin - analogs & derivatives</subject><subject>Catechin - pharmacology</subject><subject>Catechin - therapeutic use</subject><subject>chemical structure</subject><subject>Drug Resistance, Multiple</subject><subject>epicatechin</subject><subject>epigallocatechin</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Letter</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>multiple drug resistance</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytotherapy</subject><subject>Plants, Medicinal</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - drug effects</subject><issn>0032-0943</issn><issn>1439-0221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10D1vFDEQgGELgcgRKGlhGxCRsjD2eP1RogNCpERIhNSW1-u9c7Qfh70u8u_xaU9KRWUXj2Y0LyFvKXym0DRfUs0AeK2wUQKekQ3lqGtgjD4nGwBkNWiOZ-RVSg8AlGuAl-SMNoJjI8SG3G7t4t0-TNXODkP5pypM-9CGpRrzsIQu5l0VfQppsZPz1afbb78vCqnuFnvYPw6zm53LqbI5-pxekxe9HZJ_c3rPyf2P73-2P-ubX1fX2683tUPFlppR2iNIVL6TXFvfCoZeoJINcy0gbwVq3XVWNVxxTb2TUvWeOotIJZMNnpOP69xDnP9mnxYzhuR8OWDyc05GSKqlokdYr9DFOaXoe3OIYbTx0VAwx34mmWM_s_Yr_t1pcG5H3z3pU7ACPpyATc4OfSxVQnpy5YqGoi7ucnXLPvjRm4c5x6kk-e_e9yvv7WzsLpaR93cMKALoUkUg_gNUno2H</recordid><startdate>20041201</startdate><enddate>20041201</enddate><creator>Gibbons, S</creator><creator>Moser, E</creator><creator>Kaatz, G.W</creator><general>Thieme</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041201</creationdate><title>Catechin gallates inhibit multidrug resistance (MDR) in Staphylococcus aureus</title><author>Gibbons, S ; Moser, E ; Kaatz, G.W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-211f30738ed749aeb623e638752cb034b6399dda8548491ec778fe1ca33172753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>antibacterial properties</topic><topic>Biological and medical sciences</topic><topic>catechin</topic><topic>Catechin - administration & dosage</topic><topic>Catechin - analogs & derivatives</topic><topic>Catechin - pharmacology</topic><topic>Catechin - therapeutic use</topic><topic>chemical structure</topic><topic>Drug Resistance, Multiple</topic><topic>epicatechin</topic><topic>epigallocatechin</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Letter</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>multiple drug resistance</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytotherapy</topic><topic>Plants, Medicinal</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gibbons, S</creatorcontrib><creatorcontrib>Moser, E</creatorcontrib><creatorcontrib>Kaatz, G.W</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Planta medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gibbons, S</au><au>Moser, E</au><au>Kaatz, G.W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Catechin gallates inhibit multidrug resistance (MDR) in Staphylococcus aureus</atitle><jtitle>Planta medica</jtitle><addtitle>Planta Med</addtitle><date>2004-12-01</date><risdate>2004</risdate><volume>70</volume><issue>12</issue><spage>1240</spage><epage>1242</epage><pages>1240-1242</pages><issn>0032-0943</issn><eissn>1439-0221</eissn><coden>PLMEAA</coden><abstract>Abstract
Epicatechin gallate (1) and epigallocatechin gallate (2) were evaluated for their antibacterial and efflux inhibitory activity against a wild-type and three multidrug-resistant (MDR) strains of STAPHYLOCOCCUS AUREUS. Compound 2 was more active than 1 based on minimum inhibitory concentrations (MICs; 32 - 64 versus 64 - > 512 μg/mL, respectively). When incorporated into the growth medium at 20 μg/mL, both compounds exhibited a four-fold potentiation of the activity of norfloxacin against a norfloxacin-resistant strain of S. AUREUS overexpressing the NorA multidrug efflux pump. Against this strain 1 was moderately more potent than 2 as an inhibitor of ethidium efflux, but at ≤ 20 μM both compounds paradoxically stimulated efflux. This phenomenon has not been encountered previously in the analysis of inhibitors of multidrug efflux.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>15643566</pmid><doi>10.1055/s-2004-835860</doi><tpages>3</tpages></addata></record> |
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| subjects | Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use antibacterial properties Biological and medical sciences catechin Catechin - administration & dosage Catechin - analogs & derivatives Catechin - pharmacology Catechin - therapeutic use chemical structure Drug Resistance, Multiple epicatechin epigallocatechin General pharmacology Humans Letter Medical sciences Microbial Sensitivity Tests multiple drug resistance Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plants, Medicinal Staphylococcus aureus Staphylococcus aureus - drug effects |
| title | Catechin gallates inhibit multidrug resistance (MDR) in Staphylococcus aureus |
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