Type-I interferon receptor expression: Its circadian rhythm and downregulation after interferon-α administration in peripheral blood cells from renal cancer patients

Objectives: To investigate the regulation of interferon‐α (IFN‐α) receptor expression in metastatic renal cell carcinoma (RCC) after IFN‐α administration. Methods: Blood sampling was carried out in eight patients with metastatic RCC and six healthy volunteers. Flow‐cytometric analysis using a mono...

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Veröffentlicht in:	International journal of urology 2009-04, Vol.16 (4), p.356-359
Hauptverfasser:	Shiba, Masahiro, Nonomura, Norio, Nakai, Yasutomo, Nakayama, Masashi, Takayama, Hitoshi, Inoue, Hitoshi, Tsujimura, Akira, Nishimura, Kazuo, Okuyama, Akihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Renal Cell - blood Carcinoma, Renal Cell - drug therapy Circadian Rhythm Down-Regulation downregulation Humans Immunologic Factors - pharmacology Immunologic Factors - therapeutic use interferon Interferon-alpha - pharmacology Interferon-alpha - therapeutic use Kidney Neoplasms - blood Kidney Neoplasms - drug therapy Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism receptor Receptor, Interferon alpha-beta - biosynthesis Receptor, Interferon alpha-beta - drug effects renal cell carcinoma
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