Toxoplasma gondii: Congenital transmission in a hamster model
The objective of the research was to test the hamster for a model of transmission of congenital toxoplasmosis. A non-invasive method for the diagnosis of pregnancy in hamsters was designed, with a specificity and a sensitivity of 70.2 and 94.7%, respectively ( n = 168). Of 32 females with a chronic...
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| Veröffentlicht in: | Experimental parasitology 2009-06, Vol.122 (2), p.140-144 |
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| creator | Freyre, A. Fialho, C.G. Bigatti, L.E. Araujo, F.A.P. Falcón, J.D. Mendez, J. González, M. |
| description | The objective of the research was to test the hamster for a model of transmission of congenital toxoplasmosis. A non-invasive method for the diagnosis of pregnancy in hamsters was designed, with a specificity and a sensitivity of 70.2 and 94.7%, respectively (
n
=
168). Of 32 females with a chronic toxoplasma infection, 3 transmitted
Toxoplasma congenitally during their first pregnancy, but not during the subsequent pregnancy. Congenital transmission rates of infections initiated during pregnancy with 2 stages of 2 strains of
Toxoplasma were in the range of 33 to 100% of the 76 females inoculated. Only 1 of 17 females transmitted the parasite exclusively via milk. It was concluded that the hamster is a promising species for a model of transmission of congenital toxoplasmosis. |
| doi_str_mv | 10.1016/j.exppara.2009.02.004 |
| format | Article |
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n
=
168). Of 32 females with a chronic toxoplasma infection, 3 transmitted
Toxoplasma congenitally during their first pregnancy, but not during the subsequent pregnancy. Congenital transmission rates of infections initiated during pregnancy with 2 stages of 2 strains of
Toxoplasma were in the range of 33 to 100% of the 76 females inoculated. Only 1 of 17 females transmitted the parasite exclusively via milk. It was concluded that the hamster is a promising species for a model of transmission of congenital toxoplasmosis.</description><identifier>ISSN: 0014-4894</identifier><identifier>EISSN: 1090-2449</identifier><identifier>DOI: 10.1016/j.exppara.2009.02.004</identifier><identifier>PMID: 19217907</identifier><identifier>CODEN: EXPAAA</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Animals, Newborn ; Biological and medical sciences ; Biological Assay ; Cats ; Congenital transmission ; Cricetinae ; Disease Models, Animal ; Female ; Fundamental and applied biological sciences. Psychology ; Hamster ; Infectious Disease Transmission, Vertical ; Life cycle. Host-agent relationship. Pathogenesis ; Mesocricetus ; Mice ; Milk - parasitology ; Pregnancy ; Pregnancy Complications, Parasitic - parasitology ; Pregnancy Tests ; Protozoa ; Toxoplasma gondii ; Toxoplasmosis, Animal - congenital ; Toxoplasmosis, Animal - transmission ; Toxoplasmosis, Congenital - transmission</subject><ispartof>Experimental parasitology, 2009-06, Vol.122 (2), p.140-144</ispartof><rights>2009 Elsevier Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-2549a7faed86b6db2acc1cd32d27fe88c8c01f2831567cdf40920ee8f2b35cd83</citedby><cites>FETCH-LOGICAL-c424t-2549a7faed86b6db2acc1cd32d27fe88c8c01f2831567cdf40920ee8f2b35cd83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.exppara.2009.02.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21480399$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19217907$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Freyre, A.</creatorcontrib><creatorcontrib>Fialho, C.G.</creatorcontrib><creatorcontrib>Bigatti, L.E.</creatorcontrib><creatorcontrib>Araujo, F.A.P.</creatorcontrib><creatorcontrib>Falcón, J.D.</creatorcontrib><creatorcontrib>Mendez, J.</creatorcontrib><creatorcontrib>González, M.</creatorcontrib><title>Toxoplasma gondii: Congenital transmission in a hamster model</title><title>Experimental parasitology</title><addtitle>Exp Parasitol</addtitle><description>The objective of the research was to test the hamster for a model of transmission of congenital toxoplasmosis. A non-invasive method for the diagnosis of pregnancy in hamsters was designed, with a specificity and a sensitivity of 70.2 and 94.7%, respectively (
n
=
168). Of 32 females with a chronic toxoplasma infection, 3 transmitted
Toxoplasma congenitally during their first pregnancy, but not during the subsequent pregnancy. Congenital transmission rates of infections initiated during pregnancy with 2 stages of 2 strains of
Toxoplasma were in the range of 33 to 100% of the 76 females inoculated. Only 1 of 17 females transmitted the parasite exclusively via milk. It was concluded that the hamster is a promising species for a model of transmission of congenital toxoplasmosis.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Biological and medical sciences</subject><subject>Biological Assay</subject><subject>Cats</subject><subject>Congenital transmission</subject><subject>Cricetinae</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hamster</subject><subject>Infectious Disease Transmission, Vertical</subject><subject>Life cycle. Host-agent relationship. Pathogenesis</subject><subject>Mesocricetus</subject><subject>Mice</subject><subject>Milk - parasitology</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Parasitic - parasitology</subject><subject>Pregnancy Tests</subject><subject>Protozoa</subject><subject>Toxoplasma gondii</subject><subject>Toxoplasmosis, Animal - congenital</subject><subject>Toxoplasmosis, Animal - transmission</subject><subject>Toxoplasmosis, Congenital - transmission</subject><issn>0014-4894</issn><issn>1090-2449</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0MFO3DAQgGGrKipb6CO0yqXcEsYTJ7GREEKr0lZC4rKcLa892XqVxKmdreDtCdqoHDn58s149DP2lUPBgdeX-4KextFEUyCAKgALAPGBrTgoyFEI9ZGtALjIhVTilH1OaQ8AkqP4xE65Qt4oaFbsehOewtiZ1JtsFwbn_VW2DsOOBj-ZLpuiGVLvU_JhyPyQmeyP6dNEMeuDo-6cnbSmS_Rlec_Y492PzfpXfv_w8_f69j63AsWUYyWUaVpDTtbb2m3RWMutK9Fh05KUVlrgLcqSV3VjXStAIRDJFrdlZZ0sz9jFce8Yw98DpUnPN1nqOjNQOCRdN1w1iOJdiFBVStUww-oIbQwpRWr1GH1v4rPmoF8D671eAuvXwBpQz4HnuW_LB4dtT-5taik6g-8LMMmarp0DWp_-O-RCQqnU7G6OjuZu_zxFnaynwZLzkeykXfDvnPICGjicBQ</recordid><startdate>20090601</startdate><enddate>20090601</enddate><creator>Freyre, A.</creator><creator>Fialho, C.G.</creator><creator>Bigatti, L.E.</creator><creator>Araujo, F.A.P.</creator><creator>Falcón, J.D.</creator><creator>Mendez, J.</creator><creator>González, M.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20090601</creationdate><title>Toxoplasma gondii: Congenital transmission in a hamster model</title><author>Freyre, A. ; Fialho, C.G. ; Bigatti, L.E. ; Araujo, F.A.P. ; Falcón, J.D. ; Mendez, J. ; González, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-2549a7faed86b6db2acc1cd32d27fe88c8c01f2831567cdf40920ee8f2b35cd83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Biological and medical sciences</topic><topic>Biological Assay</topic><topic>Cats</topic><topic>Congenital transmission</topic><topic>Cricetinae</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hamster</topic><topic>Infectious Disease Transmission, Vertical</topic><topic>Life cycle. Host-agent relationship. 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A non-invasive method for the diagnosis of pregnancy in hamsters was designed, with a specificity and a sensitivity of 70.2 and 94.7%, respectively (
n
=
168). Of 32 females with a chronic toxoplasma infection, 3 transmitted
Toxoplasma congenitally during their first pregnancy, but not during the subsequent pregnancy. Congenital transmission rates of infections initiated during pregnancy with 2 stages of 2 strains of
Toxoplasma were in the range of 33 to 100% of the 76 females inoculated. Only 1 of 17 females transmitted the parasite exclusively via milk. It was concluded that the hamster is a promising species for a model of transmission of congenital toxoplasmosis.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>19217907</pmid><doi>10.1016/j.exppara.2009.02.004</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Animals, Newborn Biological and medical sciences Biological Assay Cats Congenital transmission Cricetinae Disease Models, Animal Female Fundamental and applied biological sciences. Psychology Hamster Infectious Disease Transmission, Vertical Life cycle. Host-agent relationship. Pathogenesis Mesocricetus Mice Milk - parasitology Pregnancy Pregnancy Complications, Parasitic - parasitology Pregnancy Tests Protozoa Toxoplasma gondii Toxoplasmosis, Animal - congenital Toxoplasmosis, Animal - transmission Toxoplasmosis, Congenital - transmission |
| title | Toxoplasma gondii: Congenital transmission in a hamster model |
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