The ingestion of saturated fatty acid triacylglycerols acutely affects insulin secretion and insulin sensitivity in human subjects
To assess the effects of acute dietary saturated fat intake on glucose-induced insulin secretion rate (ISR), measured by the C-peptide deconvolution method, and on insulin clearance and sensitivity, five obese and five normal-weight women (controls) were studied after either a 100g oral butter load...
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| Veröffentlicht in: | British journal of nutrition 2004-12, Vol.92 (6), p.895-903 |
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| creator | Manco, Melania Bertuzzi, Alessandro Salinari, Serenella Scarfone, Antonino Calvani, Menotti Greco, Aldo V. Mingrone, Geltrude |
| description | To assess the effects of acute dietary saturated fat intake on glucose-induced insulin secretion rate (ISR), measured by the C-peptide deconvolution method, and on insulin clearance and sensitivity, five obese and five normal-weight women (controls) were studied after either a 100g oral butter load or a 100ml water load. At 120min after the oral load a hyperglycaemic clamp was performed over 180min. A dramatic increase of ISR occurred after butter compared with the water challenge in the controls (1305·6 (SE 124·1) v. 616·1 (SE 52·5) pmol/min; P |
| doi_str_mv | 10.1079/BJN20041268 |
| format | Article |
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At 120min after the oral load a hyperglycaemic clamp was performed over 180min. A dramatic increase of ISR occurred after butter compared with the water challenge in the controls (1305·6 (SE 124·1) v. 616·1 (SE 52·5) pmol/min; P<0·01) and to a lesser degree in the obese subjects (1975·0 (SE 44·1) v. 1417·5 (SE 56·0) pmol/min; P<0·05). Insulin sensitivity was impaired after butter (0·60×10−2 (SE 0·11×10−2) v. 2·26×10−2 (SE 0·32×10−2) ml/min per kgFFM per (pmol/l); P<0·01) in the controls but not in the obese group. Insulin clearance during the clamp was reduced after butter compared with after the water load only in the controls (0·89 (SE 0·22) v. 1·70 (SE 0·15) litres/min; P<0·01). The data are consistent with the hypothesis that acute excess lipid availability may lead to a compensatory elevation in glucose-induced insulin secretion as a result of the decline in insulin sensitivity and a reduced insulin clearance.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1079/BJN20041268</identifier><identifier>PMID: 15613251</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Administration, Oral ; Adult ; Biological and medical sciences ; Blood Glucose - analysis ; Butter ; C-Peptide - blood ; Diabetes ; Dietary Fats - administration & dosage ; Fatty acids ; Fatty Acids, Nonesterified - administration & dosage ; Fatty Acids, Nonesterified - blood ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Glucose ; Glucose - metabolism ; Glucose Clamp Technique - methods ; Human subjects ; Humans ; Hypertension ; Informatics ; Ingestion ; Insulin - blood ; Insulin - metabolism ; Insulin resistance ; Insulin Secretion ; Lipids ; Non-esterified fatty acids ; Obesity ; Obesity - metabolism ; Oils & fats ; Peptides ; Systems analysis ; Time Factors ; Triacylglycerols ; Triglycerides - administration & dosage ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>British journal of nutrition, 2004-12, Vol.92 (6), p.895-903</ispartof><rights>Copyright © The Nutrition Society 2004</rights><rights>2005 INIST-CNRS</rights><rights>The Nutrition Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-f6841a350a1f68d531a6d4adb938307d1b4b8e40fb17be435a4724b603e9ec3f3</citedby><cites>FETCH-LOGICAL-c481t-f6841a350a1f68d531a6d4adb938307d1b4b8e40fb17be435a4724b603e9ec3f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16426205$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15613251$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Manco, Melania</creatorcontrib><creatorcontrib>Bertuzzi, Alessandro</creatorcontrib><creatorcontrib>Salinari, Serenella</creatorcontrib><creatorcontrib>Scarfone, Antonino</creatorcontrib><creatorcontrib>Calvani, Menotti</creatorcontrib><creatorcontrib>Greco, Aldo V.</creatorcontrib><creatorcontrib>Mingrone, Geltrude</creatorcontrib><title>The ingestion of saturated fatty acid triacylglycerols acutely affects insulin secretion and insulin sensitivity in human subjects</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>To assess the effects of acute dietary saturated fat intake on glucose-induced insulin secretion rate (ISR), measured by the C-peptide deconvolution method, and on insulin clearance and sensitivity, five obese and five normal-weight women (controls) were studied after either a 100g oral butter load or a 100ml water load. At 120min after the oral load a hyperglycaemic clamp was performed over 180min. A dramatic increase of ISR occurred after butter compared with the water challenge in the controls (1305·6 (SE 124·1) v. 616·1 (SE 52·5) pmol/min; P<0·01) and to a lesser degree in the obese subjects (1975·0 (SE 44·1) v. 1417·5 (SE 56·0) pmol/min; P<0·05). Insulin sensitivity was impaired after butter (0·60×10−2 (SE 0·11×10−2) v. 2·26×10−2 (SE 0·32×10−2) ml/min per kgFFM per (pmol/l); P<0·01) in the controls but not in the obese group. Insulin clearance during the clamp was reduced after butter compared with after the water load only in the controls (0·89 (SE 0·22) v. 1·70 (SE 0·15) litres/min; P<0·01). The data are consistent with the hypothesis that acute excess lipid availability may lead to a compensatory elevation in glucose-induced insulin secretion as a result of the decline in insulin sensitivity and a reduced insulin clearance.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>Butter</subject><subject>C-Peptide - blood</subject><subject>Diabetes</subject><subject>Dietary Fats - administration & dosage</subject><subject>Fatty acids</subject><subject>Fatty Acids, Nonesterified - administration & dosage</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose</subject><subject>Glucose - metabolism</subject><subject>Glucose Clamp Technique - methods</subject><subject>Human subjects</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Informatics</subject><subject>Ingestion</subject><subject>Insulin - blood</subject><subject>Insulin - metabolism</subject><subject>Insulin resistance</subject><subject>Insulin Secretion</subject><subject>Lipids</subject><subject>Non-esterified fatty acids</subject><subject>Obesity</subject><subject>Obesity - metabolism</subject><subject>Oils & fats</subject><subject>Peptides</subject><subject>Systems analysis</subject><subject>Time Factors</subject><subject>Triacylglycerols</subject><subject>Triglycerides - administration & dosage</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkUtv1DAQgC0EotvCiTtESPSCAh7bcZIjrOgDrUCo2wsXa-LYWy95tLZTsdf-clx21a0QJ3tmPn-e0RDyCugHoGX98fPXb4xSAUxWT8gMRFnkTEr2lMwopWUOIIoDchjCOoUV0Po5OYBCAmcFzMjd8spkbliZEN04ZKPNAsbJYzRtZjHGTYbatVn0DvWmW3UbbfzYhZSdoulS1VqjY0iKMHVuyILR3vxV4dA-yg7BRXfrki-FV1OPKTk16_u3L8gzi10wL3fnEbk8-bKcn-WL76fn80-LXIsKYm5lJQB5QRHStS04oGwFtk3NK07LFhrRVEZQ20DZGMELFCUTjaTc1EZzy4_I8dZ77cebKQ2sehe06ToczDgFJUuoJavqBL79B1yPkx9Sb4pB-oxJKhL0fgtpP4bgjVXX3vXoNwqout-LerSXRL_eKaemN-2e3S0iAe92AAaNnfU4aBf2nBRMMlokLt9yLkTz-6GO_lfqn5eFkqc_1M9qcXG2OFmqeeLfbHmLo8KVT87LC0aBU6CMCyH2Ro194127Mvtx_zfKHx4DvYY</recordid><startdate>20041201</startdate><enddate>20041201</enddate><creator>Manco, Melania</creator><creator>Bertuzzi, Alessandro</creator><creator>Salinari, Serenella</creator><creator>Scarfone, Antonino</creator><creator>Calvani, Menotti</creator><creator>Greco, Aldo V.</creator><creator>Mingrone, Geltrude</creator><general>Cambridge University Press</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20041201</creationdate><title>The ingestion of saturated fatty acid triacylglycerols acutely affects insulin secretion and insulin sensitivity in human subjects</title><author>Manco, Melania ; Bertuzzi, Alessandro ; Salinari, Serenella ; Scarfone, Antonino ; Calvani, Menotti ; Greco, Aldo V. ; Mingrone, Geltrude</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-f6841a350a1f68d531a6d4adb938307d1b4b8e40fb17be435a4724b603e9ec3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>Butter</topic><topic>C-Peptide - blood</topic><topic>Diabetes</topic><topic>Dietary Fats - administration & dosage</topic><topic>Fatty acids</topic><topic>Fatty Acids, Nonesterified - administration & dosage</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>Feeding. 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Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manco, Melania</au><au>Bertuzzi, Alessandro</au><au>Salinari, Serenella</au><au>Scarfone, Antonino</au><au>Calvani, Menotti</au><au>Greco, Aldo V.</au><au>Mingrone, Geltrude</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The ingestion of saturated fatty acid triacylglycerols acutely affects insulin secretion and insulin sensitivity in human subjects</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2004-12-01</date><risdate>2004</risdate><volume>92</volume><issue>6</issue><spage>895</spage><epage>903</epage><pages>895-903</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>To assess the effects of acute dietary saturated fat intake on glucose-induced insulin secretion rate (ISR), measured by the C-peptide deconvolution method, and on insulin clearance and sensitivity, five obese and five normal-weight women (controls) were studied after either a 100g oral butter load or a 100ml water load. At 120min after the oral load a hyperglycaemic clamp was performed over 180min. A dramatic increase of ISR occurred after butter compared with the water challenge in the controls (1305·6 (SE 124·1) v. 616·1 (SE 52·5) pmol/min; P<0·01) and to a lesser degree in the obese subjects (1975·0 (SE 44·1) v. 1417·5 (SE 56·0) pmol/min; P<0·05). Insulin sensitivity was impaired after butter (0·60×10−2 (SE 0·11×10−2) v. 2·26×10−2 (SE 0·32×10−2) ml/min per kgFFM per (pmol/l); P<0·01) in the controls but not in the obese group. Insulin clearance during the clamp was reduced after butter compared with after the water load only in the controls (0·89 (SE 0·22) v. 1·70 (SE 0·15) litres/min; P<0·01). The data are consistent with the hypothesis that acute excess lipid availability may lead to a compensatory elevation in glucose-induced insulin secretion as a result of the decline in insulin sensitivity and a reduced insulin clearance.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>15613251</pmid><doi>10.1079/BJN20041268</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Administration, Oral Adult Biological and medical sciences Blood Glucose - analysis Butter C-Peptide - blood Diabetes Dietary Fats - administration & dosage Fatty acids Fatty Acids, Nonesterified - administration & dosage Fatty Acids, Nonesterified - blood Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Glucose Glucose - metabolism Glucose Clamp Technique - methods Human subjects Humans Hypertension Informatics Ingestion Insulin - blood Insulin - metabolism Insulin resistance Insulin Secretion Lipids Non-esterified fatty acids Obesity Obesity - metabolism Oils & fats Peptides Systems analysis Time Factors Triacylglycerols Triglycerides - administration & dosage Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | The ingestion of saturated fatty acid triacylglycerols acutely affects insulin secretion and insulin sensitivity in human subjects |
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