HO-1-mediated macroautophagy: a mechanism for unregulated iron deposition in aging and degenerating neural tissues

Oxidative stress, deposition of non-transferrin iron, and mitochondrial insufficiency occur in the brains of patients with Alzheimer disease (AD) and Parkinson disease (PD). We previously demonstrated that heme oxygenase-1 (HO-1) is up-regulated in AD and PD brain and promotes the accumulation of no...

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Veröffentlicht in:	Journal of neurochemistry 2009-05, Vol.109 (3), p.776-791
Hauptverfasser:	Zukor, Hillel, Song, Wei, Liberman, Adrienne, Mui, Jeannie, Vali, Hojatollah, Fillebeen, Carine, Pantopoulos, Kostas, Wu, Ting-Di, Guerquin-Kern, Jean-Luc, Schipper, Hyman M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Animals Animals, Newborn Astrocytes - metabolism Astrocytes - ultrastructure Autophagy - drug effects Autophagy - physiology Biochemistry Biological and medical sciences Cells, Cultured Cerebral Cortex - cytology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Electrophoretic Mobility Shift Assay - methods Ferric Compounds - metabolism heme oxygenase-1 Heme Oxygenase-1 - antagonists & inhibitors Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism Humans Iron Iron - metabolism Medical sciences Mesoporphyrins - pharmacology Microscopy, Electron, Transmission - methods mitochondria Mitochondria - drug effects neurodegenerative disease Neurological disorders Neurology Organic mental disorders. Neuropsychology Oxidation oxidative stress Proteins Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Rats Rats, Sprague-Dawley secondary ion mass spectrometry imaging Spectrometry, Mass, Secondary Ion - methods Subcellular Fractions - drug effects Subcellular Fractions - metabolism Time Factors Transfection - methods
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