Intracellular Glutathione Regulates Sesquiterpene Lactone-induced Conversion of Autophagy to Apoptosis in Human Leukemia HL60 Cells

A sesquiterpene lactone, eupalinin A, found in Eupatorium chinense L., exhibited a marked inhibitory effect on cell growth in HL60 cells. In a previous study, it was indicated that the intracellular ROS generation accompanying mitochondrial dysfunction was closely related to the autophagic cell deat...

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Veröffentlicht in:	Anticancer research 2009-04, Vol.29 (4), p.1449-1457
Hauptverfasser:	ITOH, Tomohiro, OHGUCHI, Kenji, NOZAWA, Yoshinori, AKAO, Yukihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Autophagy - drug effects Biological and medical sciences Eupatorium Glutathione - metabolism Growth Inhibitors - pharmacology Hematologic and hematopoietic diseases HL-60 Cells Humans Imidazoles - pharmacology Lactones - pharmacology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - metabolism Pyridines - pharmacology Reactive Oxygen Species - metabolism Sesquiterpenes - pharmacology Tumors
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