Association of hormone receptor status with grading, age of onset, and tumor size in BRCA1-associated breast cancer

BRCA1 -associated breast cancer frequently presents with estrogen-receptor (ERα) and progesterone-receptor (PR) negativity, grade 3, and early onset. In contrast, in BRCA1 -deficient mice, ERα is highly expressed in early tumorigenesis. In a retrospective cohort study on 587 breast cancer patients w...

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Veröffentlicht in:	Virchows Archiv : an international journal of pathology 2009-05, Vol.454 (5), p.519-524
Hauptverfasser:	Graeser, M., Bosse, K., Brosig, M., Engel, C., Schmutzler, R. K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age of Onset Aged Aged, 80 and over Biological and medical sciences BRCA1 Protein - genetics Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma, Intraductal, Noninfiltrating - genetics Carcinoma, Intraductal, Noninfiltrating - metabolism Carcinoma, Intraductal, Noninfiltrating - pathology Estrogen Receptor alpha - metabolism Estrogens Female Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Mammary gland diseases Medical sciences Medicine Medicine & Public Health Middle Aged Mutation Original Article Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Receptors, Progesterone - metabolism Retrospective Studies Tumors Young Adult
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