Factors predicting improvement in primary generalized dystonia treated by pallidal deep brain stimulation
Despite the beneficial effects of Globus Pallidus internus (GPi) deep brain stimulation (DBS) in patients with primary generalized dystonia (PGD), the degree of improvement varies from one patient to another. The objective of this study was to examine the effects of clinical, anatomical (volume of t...
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| Veröffentlicht in: | Movement disorders 2009-04, Vol.24 (6), p.846-853 |
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| creator | Vasques, Xavier Cif, Laura Gonzalez, Victoria Nicholson, Claire Coubes, Philippe |
| description | Despite the beneficial effects of Globus Pallidus internus (GPi) deep brain stimulation (DBS) in patients with primary generalized dystonia (PGD), the degree of improvement varies from one patient to another. The objective of this study was to examine the effects of clinical, anatomical (volume of the GPi), and electrical variables on the postoperative Burke‐Fahn‐Marsden Dystonia rating scale (BFMDRS) motor score to identify which factors may be predictive of the degree of improvement. We reviewed retrospectively the clinical records of 40 steady‐state patients with PGD who had been treated by bilateral GPi lead implantation. The follow‐up period was 2 to 8 years. The correlation between the electrical parameters (voltage, impedance, and current) and the clinical outcome was studied. An analysis of covariance was performed to identify factors predictive of the magnitude of improvement. The most influential factors according to the model are as follows: the preoperative BFMDRS score (P < 0.0001); age at surgery (P < 0.0001); the right GPi volume (P = 0.002); the left stimulated GPi volume (P = 0.005). No significant correlation was found between the electrical parameters used and the mean motor scores in steady state. © 2009 Movement Disorder Society |
| doi_str_mv | 10.1002/mds.22433 |
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The objective of this study was to examine the effects of clinical, anatomical (volume of the GPi), and electrical variables on the postoperative Burke‐Fahn‐Marsden Dystonia rating scale (BFMDRS) motor score to identify which factors may be predictive of the degree of improvement. We reviewed retrospectively the clinical records of 40 steady‐state patients with PGD who had been treated by bilateral GPi lead implantation. The follow‐up period was 2 to 8 years. The correlation between the electrical parameters (voltage, impedance, and current) and the clinical outcome was studied. An analysis of covariance was performed to identify factors predictive of the magnitude of improvement. The most influential factors according to the model are as follows: the preoperative BFMDRS score (P < 0.0001); age at surgery (P < 0.0001); the right GPi volume (P = 0.002); the left stimulated GPi volume (P = 0.005). No significant correlation was found between the electrical parameters used and the mean motor scores in steady state. © 2009 Movement Disorder Society</description><identifier>ISSN: 0885-3185</identifier><identifier>EISSN: 1531-8257</identifier><identifier>DOI: 10.1002/mds.22433</identifier><identifier>PMID: 19199337</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Analysis of Variance ; Biological and medical sciences ; Child ; Child, Preschool ; clinical outcome predictors ; deep brain stimulation ; Deep Brain Stimulation - methods ; Diseases of striated muscles. Neuromuscular diseases ; Dystonic Disorders - therapy ; Female ; Globus Pallidus - physiology ; globus pallidus internus ; Humans ; Imaging, Three-Dimensional ; Magnetic Resonance Imaging - methods ; Male ; Medical sciences ; Middle Aged ; Neurology ; Outcome Assessment (Health Care) - methods ; Predictive Value of Tests ; primary generalized dystonia ; Severity of Illness Index ; Statistics as Topic ; Young Adult</subject><ispartof>Movement disorders, 2009-04, Vol.24 (6), p.846-853</ispartof><rights>Copyright © 2009 Movement Disorder Society</rights><rights>2009 INIST-CNRS</rights><rights>(c) 2009 Movement Disorder Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4883-2cd0959ae66b13dc39daf4c937b9a90ef353b38e32fb0c0f74edf6620a41e55d3</citedby><cites>FETCH-LOGICAL-c4883-2cd0959ae66b13dc39daf4c937b9a90ef353b38e32fb0c0f74edf6620a41e55d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmds.22433$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmds.22433$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21430970$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19199337$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vasques, Xavier</creatorcontrib><creatorcontrib>Cif, Laura</creatorcontrib><creatorcontrib>Gonzalez, Victoria</creatorcontrib><creatorcontrib>Nicholson, Claire</creatorcontrib><creatorcontrib>Coubes, Philippe</creatorcontrib><title>Factors predicting improvement in primary generalized dystonia treated by pallidal deep brain stimulation</title><title>Movement disorders</title><addtitle>Mov. Disord</addtitle><description>Despite the beneficial effects of Globus Pallidus internus (GPi) deep brain stimulation (DBS) in patients with primary generalized dystonia (PGD), the degree of improvement varies from one patient to another. The objective of this study was to examine the effects of clinical, anatomical (volume of the GPi), and electrical variables on the postoperative Burke‐Fahn‐Marsden Dystonia rating scale (BFMDRS) motor score to identify which factors may be predictive of the degree of improvement. We reviewed retrospectively the clinical records of 40 steady‐state patients with PGD who had been treated by bilateral GPi lead implantation. The follow‐up period was 2 to 8 years. The correlation between the electrical parameters (voltage, impedance, and current) and the clinical outcome was studied. An analysis of covariance was performed to identify factors predictive of the magnitude of improvement. The most influential factors according to the model are as follows: the preoperative BFMDRS score (P < 0.0001); age at surgery (P < 0.0001); the right GPi volume (P = 0.002); the left stimulated GPi volume (P = 0.005). No significant correlation was found between the electrical parameters used and the mean motor scores in steady state. © 2009 Movement Disorder Society</description><subject>Adolescent</subject><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>clinical outcome predictors</subject><subject>deep brain stimulation</subject><subject>Deep Brain Stimulation - methods</subject><subject>Diseases of striated muscles. Neuromuscular diseases</subject><subject>Dystonic Disorders - therapy</subject><subject>Female</subject><subject>Globus Pallidus - physiology</subject><subject>globus pallidus internus</subject><subject>Humans</subject><subject>Imaging, Three-Dimensional</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Outcome Assessment (Health Care) - methods</subject><subject>Predictive Value of Tests</subject><subject>primary generalized dystonia</subject><subject>Severity of Illness Index</subject><subject>Statistics as Topic</subject><subject>Young Adult</subject><issn>0885-3185</issn><issn>1531-8257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EokvhwB9AvoDEIa0_4jg-0kILYlvElzhaE3tSGZxksb3A8utJ2VBOiNNIM887Xy8hDzk74oyJ48HnIyFqKW-RFVeSV61Q-jZZsbZVleStOiD3cv7MGOeKN3fJATfcGCn1ioQzcGVKmW4S-uBKGK9oGDZp-oYDjoWGca6EAdKOXuGICWL4iZ76XS7TGICWhFDmRLejG4gxeIjUI25ol2DW5hKGbYQSpvE-udNDzPhgiYfk49mLD6cvq_Wb81enz9aVq9tWVsJ5ZpQBbJqOS--k8dDXzkjdGTAMe6lkJ1uUou-YY72u0fdNIxjUHJXy8pA82fedj_i6xVzsELLDGGHEaZtto7mpTcP-CwrONRdazeDTPejSlHPC3i4vsZzZawPsbID9bcDMPlqabrsB_V9y-fgMPF4AyA5in2B0Id9wgteSGX293fGe-x4i7v490V48f_9ndLVXhFzwx40C0pf5ZqmV_XR5bln9-u3JxfrSvpO_ACyJrcM</recordid><startdate>20090430</startdate><enddate>20090430</enddate><creator>Vasques, Xavier</creator><creator>Cif, Laura</creator><creator>Gonzalez, Victoria</creator><creator>Nicholson, Claire</creator><creator>Coubes, Philippe</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20090430</creationdate><title>Factors predicting improvement in primary generalized dystonia treated by pallidal deep brain stimulation</title><author>Vasques, Xavier ; Cif, Laura ; Gonzalez, Victoria ; Nicholson, Claire ; Coubes, Philippe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4883-2cd0959ae66b13dc39daf4c937b9a90ef353b38e32fb0c0f74edf6620a41e55d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>clinical outcome predictors</topic><topic>deep brain stimulation</topic><topic>Deep Brain Stimulation - methods</topic><topic>Diseases of striated muscles. Neuromuscular diseases</topic><topic>Dystonic Disorders - therapy</topic><topic>Female</topic><topic>Globus Pallidus - physiology</topic><topic>globus pallidus internus</topic><topic>Humans</topic><topic>Imaging, Three-Dimensional</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Outcome Assessment (Health Care) - methods</topic><topic>Predictive Value of Tests</topic><topic>primary generalized dystonia</topic><topic>Severity of Illness Index</topic><topic>Statistics as Topic</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vasques, Xavier</creatorcontrib><creatorcontrib>Cif, Laura</creatorcontrib><creatorcontrib>Gonzalez, Victoria</creatorcontrib><creatorcontrib>Nicholson, Claire</creatorcontrib><creatorcontrib>Coubes, Philippe</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Movement disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vasques, Xavier</au><au>Cif, Laura</au><au>Gonzalez, Victoria</au><au>Nicholson, Claire</au><au>Coubes, Philippe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors predicting improvement in primary generalized dystonia treated by pallidal deep brain stimulation</atitle><jtitle>Movement disorders</jtitle><addtitle>Mov. 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The correlation between the electrical parameters (voltage, impedance, and current) and the clinical outcome was studied. An analysis of covariance was performed to identify factors predictive of the magnitude of improvement. The most influential factors according to the model are as follows: the preoperative BFMDRS score (P < 0.0001); age at surgery (P < 0.0001); the right GPi volume (P = 0.002); the left stimulated GPi volume (P = 0.005). No significant correlation was found between the electrical parameters used and the mean motor scores in steady state. © 2009 Movement Disorder Society</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>19199337</pmid><doi>10.1002/mds.22433</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Adult Analysis of Variance Biological and medical sciences Child Child, Preschool clinical outcome predictors deep brain stimulation Deep Brain Stimulation - methods Diseases of striated muscles. Neuromuscular diseases Dystonic Disorders - therapy Female Globus Pallidus - physiology globus pallidus internus Humans Imaging, Three-Dimensional Magnetic Resonance Imaging - methods Male Medical sciences Middle Aged Neurology Outcome Assessment (Health Care) - methods Predictive Value of Tests primary generalized dystonia Severity of Illness Index Statistics as Topic Young Adult |
| title | Factors predicting improvement in primary generalized dystonia treated by pallidal deep brain stimulation |
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