Do polymorphisms in the familial Parkinsonism genes contribute to risk for sporadic Parkinson's disease?

Recent whole genome association studies provided little evidence that polymorphisms at the familial Parkinsonism loci influence the risk for Parkinson's disease (PD). However, these studies are not designed to detect the types of subtle effects that common variants may impose. Here, we use an a...

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Veröffentlicht in:	Movement disorders 2009-04, Vol.24 (6), p.833-838
Hauptverfasser:	Sutherland, Greg T., Halliday, Glenda M., Silburn, Peter A., Mastaglia, Frank L., Rowe, Dominic B., Boyle, Richard S., O'Sullivan, John D., Ly, Tina, Wilton, Steve D., Mellick, George D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged alpha-Synuclein - genetics association Australia - epidemiology Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Gene Frequency Genetic Predisposition to Disease Genome-Wide Association Study Genotype Glucosylceramidase - genetics High-Temperature Requirement A Serine Peptidase 2 Humans Intracellular Signaling Peptides and Proteins - genetics Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Male Medical sciences Mitochondrial Proteins - genetics Neurology Oncogene Proteins - genetics Parkinson Disease - genetics Parkinson's disease Parkinsonian Disorders - genetics PD-related genes Polymorphism, Genetic - genetics Protein Deglycase DJ-1 Protein Kinases - genetics Protein-Serine-Threonine Kinases - genetics Proton-Translocating ATPases - genetics Retrospective Studies Serine Endopeptidases - genetics tau Proteins - genetics Ubiquitin Thiolesterase - genetics Ubiquitin-Protein Ligases - genetics
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