A review of the natural course of bipolar disorders (manic―depressive psychosis) in the pre-drug era Review of studies prior to 1950

A review of the most important original studies describing the natural course of bipolar disorder (manic-depressive psychosis) published in the pre-drug era - before 1950 - is conducted. Discrepancies among studies are detected, most of which are likely explained by methodological differences. Howev...

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