Role of cytokines in anaphylactoid reaction with marked eosinophilia in a hemodialysis patient

Hemodialysis is rarely terminated by events associated with anticoagulants. A 69-year-old woman on hemodialysis due to chronic renal failure (CRF) developed an anaphylactoid reaction with hypereosinophilia. On the basis of clinical and laboratory findings, we concluded that the causes of this anaphy...

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Veröffentlicht in:Clinical and experimental nephrology 2004-12, Vol.8 (4), p.384-387
Hauptverfasser: Kanda, Eiichiro, Kida, Yujiro, Suzuki, Hitoe, Ando, Minoru, Nihei, Hiroshi, Sasaki, Sei, Saito, Hiroshi
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container_end_page 387
container_issue 4
container_start_page 384
container_title Clinical and experimental nephrology
container_volume 8
creator Kanda, Eiichiro
Kida, Yujiro
Suzuki, Hitoe
Ando, Minoru
Nihei, Hiroshi
Sasaki, Sei
Saito, Hiroshi
description Hemodialysis is rarely terminated by events associated with anticoagulants. A 69-year-old woman on hemodialysis due to chronic renal failure (CRF) developed an anaphylactoid reaction with hypereosinophilia. On the basis of clinical and laboratory findings, we concluded that the causes of this anaphylactoid reaction were low-molecular-weight heparin and heparin. Our patient also showed high levels of soluble interleukin-2 receptor (sIL-2R) and eosinophil cationic protein (ECP), which decreased after the cessation of hemo-dialysis. To date, there has been no report of high levels of cytokines induced by hemodialysis-associated anaphylactoid reaction. In this report, we discuss the mechanism underlying drug-induced anaphylactoid reaction, particularly that involving eosinophilia and cytokines.
doi_str_mv 10.1007/s10157-004-0300-4
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subjects Aged
Anaphylaxis - blood
Anaphylaxis - etiology
Anaphylaxis - immunology
Cytokines - blood
Cytokines - immunology
Eosinophil Cationic Protein - blood
Eosinophilia - immunology
Female
Heparin - immunology
Humans
Kidney Failure, Chronic - therapy
Receptors, Interleukin-2 - blood
Renal Dialysis - adverse effects
title Role of cytokines in anaphylactoid reaction with marked eosinophilia in a hemodialysis patient
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