Gene Discovery in Boophilus microplus, the Cattle Tick: The Transcriptomes of Ovaries, Salivary Glands, and Hemocytes
: The quest for new control strategies for ticks can profit from high throughput genomics. In order to identify genes that are involved in oogenesis and development, in defense, and in hematophagy, the transcriptomes of ovaries, hemocytes, and salivary glands from rapidly ingurgitating females, and...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 2004-10, Vol.1026 (1), p.242-246 |
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| creator | DE MIRANDA SANTOS, ISABEL K. F. VALENZUELA, JESUS G. RIBEIRO, JOSÉ MARCOS C. DE CASTRO, MARILIA COSTA, JULIANA NARDELLI COSTA, ANA MARIA DA SILVA, EDSON RAMIRO NETO, OLAVO BILAC REGO ROCHA, CLARISSE DAFFRE, SIRLEI FERREIRA, BEATRIZ R. DA SILVA, JOÃO SANTANA SZABÓ, MATIAS PABLO BECHARA, GERVASIO HENRIQUE |
| description | : The quest for new control strategies for ticks can profit from high throughput genomics. In order to identify genes that are involved in oogenesis and development, in defense, and in hematophagy, the transcriptomes of ovaries, hemocytes, and salivary glands from rapidly ingurgitating females, and of salivary glands from males of Boophilus microplus were PCR amplified, and the expressed sequence tags (EST) of random clones were mass sequenced. So far, more than 1,344 EST have been generated for these tissues, with approximately 30% novelty, depending on the the tissue studied. To date approximately 760 nucleotide sequences from B. microplus are deposited in the NCBI database. Mass sequencing of partial cDNAs of parasite genes can build up this scant database and rapidly generate a large quantity of useful information about potential targets for immunobiological or chemical control. |
| doi_str_mv | 10.1196/annals.1307.037 |
| format | Article |
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F. ; VALENZUELA, JESUS G. ; RIBEIRO, JOSÉ MARCOS C. ; DE CASTRO, MARILIA ; COSTA, JULIANA NARDELLI ; COSTA, ANA MARIA ; DA SILVA, EDSON RAMIRO ; NETO, OLAVO BILAC REGO ; ROCHA, CLARISSE ; DAFFRE, SIRLEI ; FERREIRA, BEATRIZ R. ; DA SILVA, JOÃO SANTANA ; SZABÓ, MATIAS PABLO ; BECHARA, GERVASIO HENRIQUE</creator><creatorcontrib>DE MIRANDA SANTOS, ISABEL K. F. ; VALENZUELA, JESUS G. ; RIBEIRO, JOSÉ MARCOS C. ; DE CASTRO, MARILIA ; COSTA, JULIANA NARDELLI ; COSTA, ANA MARIA ; DA SILVA, EDSON RAMIRO ; NETO, OLAVO BILAC REGO ; ROCHA, CLARISSE ; DAFFRE, SIRLEI ; FERREIRA, BEATRIZ R. ; DA SILVA, JOÃO SANTANA ; SZABÓ, MATIAS PABLO ; BECHARA, GERVASIO HENRIQUE</creatorcontrib><description>: The quest for new control strategies for ticks can profit from high throughput genomics. In order to identify genes that are involved in oogenesis and development, in defense, and in hematophagy, the transcriptomes of ovaries, hemocytes, and salivary glands from rapidly ingurgitating females, and of salivary glands from males of Boophilus microplus were PCR amplified, and the expressed sequence tags (EST) of random clones were mass sequenced. So far, more than 1,344 EST have been generated for these tissues, with approximately 30% novelty, depending on the the tissue studied. To date approximately 760 nucleotide sequences from B. microplus are deposited in the NCBI database. 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F.</creatorcontrib><creatorcontrib>VALENZUELA, JESUS G.</creatorcontrib><creatorcontrib>RIBEIRO, JOSÉ MARCOS C.</creatorcontrib><creatorcontrib>DE CASTRO, MARILIA</creatorcontrib><creatorcontrib>COSTA, JULIANA NARDELLI</creatorcontrib><creatorcontrib>COSTA, ANA MARIA</creatorcontrib><creatorcontrib>DA SILVA, EDSON RAMIRO</creatorcontrib><creatorcontrib>NETO, OLAVO BILAC REGO</creatorcontrib><creatorcontrib>ROCHA, CLARISSE</creatorcontrib><creatorcontrib>DAFFRE, SIRLEI</creatorcontrib><creatorcontrib>FERREIRA, BEATRIZ R.</creatorcontrib><creatorcontrib>DA SILVA, JOÃO SANTANA</creatorcontrib><creatorcontrib>SZABÓ, MATIAS PABLO</creatorcontrib><creatorcontrib>BECHARA, GERVASIO HENRIQUE</creatorcontrib><title>Gene Discovery in Boophilus microplus, the Cattle Tick: The Transcriptomes of Ovaries, Salivary Glands, and Hemocytes</title><title>Annals of the New York Academy of Sciences</title><addtitle>Ann N Y Acad Sci</addtitle><description>: The quest for new control strategies for ticks can profit from high throughput genomics. In order to identify genes that are involved in oogenesis and development, in defense, and in hematophagy, the transcriptomes of ovaries, hemocytes, and salivary glands from rapidly ingurgitating females, and of salivary glands from males of Boophilus microplus were PCR amplified, and the expressed sequence tags (EST) of random clones were mass sequenced. So far, more than 1,344 EST have been generated for these tissues, with approximately 30% novelty, depending on the the tissue studied. To date approximately 760 nucleotide sequences from B. microplus are deposited in the NCBI database. Mass sequencing of partial cDNAs of parasite genes can build up this scant database and rapidly generate a large quantity of useful information about potential targets for immunobiological or chemical control.</description><subject>Animals</subject><subject>Boophilus microplus</subject><subject>Cattle</subject><subject>Cattle Diseases - parasitology</subject><subject>Databases, Genetic</subject><subject>DNA, Complementary - analysis</subject><subject>Female</subject><subject>Gene Library</subject><subject>Hemocytes</subject><subject>Ixodidae</subject><subject>Male</subject><subject>Oogenesis - genetics</subject><subject>Ovary</subject><subject>Polymerase Chain Reaction</subject><subject>Salivary Glands</subject><subject>Sequence Analysis, DNA</subject><subject>Ticks - genetics</subject><subject>Ticks - pathogenicity</subject><subject>transcriptomes</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS0EokvhzA35xIlsx47Xjrl1A2yRqhapixAnyzizqmkSBzsp7L-vV1mVYy_2aPTNaN57hLxlsGRMyzPb97ZNS1aCWkKpnpEFU0IXUpb8OVkAKFVUmpcn5FVKvwEYr4R6SU7YSoJYASzItMEe6SefXLjHuKe-p-sQhlvfTol23sUw5OoDHW-R1nYcW6Rb7-4-0m1ubKPtk4t-GEOHiYYdvb630WPmb2zrc72nm9b2TW7kl15gF9x-xPSavNjlu_HN8T8l37983tYXxeX15mt9flk4AZoXQjeONU5yzR0TAqyQYNEJrVaqEk2FVWUll0pyCxVyaZEjF2pXaQApGS9Pyft57xDDnwnTaLqsFNt8E4YpGamYZtmfJ0F-cFsBy-DZDGZnUoq4M0P0XRZqGJgDZOZIzCESkyPJE--Oq6dfHTb_-WMGGRAz8Ne3uH9qn7n6eX7DxUFbMY_5NOK_xzEb77KsUq3Mj6uNWdc1l6C-mXX5AHrXpyo</recordid><startdate>200410</startdate><enddate>200410</enddate><creator>DE MIRANDA SANTOS, ISABEL K. 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F.</au><au>VALENZUELA, JESUS G.</au><au>RIBEIRO, JOSÉ MARCOS C.</au><au>DE CASTRO, MARILIA</au><au>COSTA, JULIANA NARDELLI</au><au>COSTA, ANA MARIA</au><au>DA SILVA, EDSON RAMIRO</au><au>NETO, OLAVO BILAC REGO</au><au>ROCHA, CLARISSE</au><au>DAFFRE, SIRLEI</au><au>FERREIRA, BEATRIZ R.</au><au>DA SILVA, JOÃO SANTANA</au><au>SZABÓ, MATIAS PABLO</au><au>BECHARA, GERVASIO HENRIQUE</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gene Discovery in Boophilus microplus, the Cattle Tick: The Transcriptomes of Ovaries, Salivary Glands, and Hemocytes</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann N Y Acad Sci</addtitle><date>2004-10</date><risdate>2004</risdate><volume>1026</volume><issue>1</issue><spage>242</spage><epage>246</epage><pages>242-246</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><abstract>: The quest for new control strategies for ticks can profit from high throughput genomics. In order to identify genes that are involved in oogenesis and development, in defense, and in hematophagy, the transcriptomes of ovaries, hemocytes, and salivary glands from rapidly ingurgitating females, and of salivary glands from males of Boophilus microplus were PCR amplified, and the expressed sequence tags (EST) of random clones were mass sequenced. So far, more than 1,344 EST have been generated for these tissues, with approximately 30% novelty, depending on the the tissue studied. To date approximately 760 nucleotide sequences from B. microplus are deposited in the NCBI database. Mass sequencing of partial cDNAs of parasite genes can build up this scant database and rapidly generate a large quantity of useful information about potential targets for immunobiological or chemical control.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>15604500</pmid><doi>10.1196/annals.1307.037</doi><tpages>5</tpages></addata></record> |
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| ispartof | Annals of the New York Academy of Sciences, 2004-10, Vol.1026 (1), p.242-246 |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Animals Boophilus microplus Cattle Cattle Diseases - parasitology Databases, Genetic DNA, Complementary - analysis Female Gene Library Hemocytes Ixodidae Male Oogenesis - genetics Ovary Polymerase Chain Reaction Salivary Glands Sequence Analysis, DNA Ticks - genetics Ticks - pathogenicity transcriptomes |
| title | Gene Discovery in Boophilus microplus, the Cattle Tick: The Transcriptomes of Ovaries, Salivary Glands, and Hemocytes |
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