Low density lipoprotein receptor-related protein mediates endocytic clearance of pro-MMP-2.TIMP-2 complex through a thrombospondin-independent mechanism

The low density lipoprotein receptor-related protein (LRP) mediates the endocytic clearance of various proteinases and proteinase.inhibitor complexes, including thrombospondin (TSP)-dependent endocytosis of matrix metalloproteinase (MMP)-2 (or gelatinase A), a key effector of extracellular matrix re...

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Veröffentlicht in:	The Journal of biological chemistry 2004-12, Vol.279 (52), p.54944-54951
Hauptverfasser:	Emonard, Hervé, Bellon, Georges, Troeberg, Linda, Berton, Alix, Robinet, Arnaud, Henriet, Patrick, Marbaix, Etienne, Kirkegaard, Kirstine, Patthy, László, Eeckhout, Yves, Nagase, Hideaki, Hornebeck, William, Courtoy, Pierre J
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Cell Line Cell Membrane - metabolism Collagen - metabolism Culture Media, Conditioned Endocytosis - physiology Fibrosarcoma Gene Expression Humans Low Density Lipoprotein Receptor-Related Protein-1 - physiology Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - metabolism Protein Precursors - genetics Protein Precursors - metabolism Recombinant Proteins Thrombospondin 1 - metabolism Thrombospondin 1 - pharmacology Thrombospondins - physiology Tissue Inhibitor of Metalloproteinase-2 - genetics Tissue Inhibitor of Metalloproteinase-2 - metabolism Transfection Tumor Cells, Cultured
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