Direct Cell Cycle Regulation by the Fibroblast Growth Factor Receptor (FGFR) Kinase through Phosphorylation-dependent Release of Cks1 from FGFR Substrate 2

Fibroblast growth factors (FGFs) are upstream activators of the mitogen-activated protein kinase pathway and mitogens in a wide variety of cells. However, whether the mitogen-activated protein kinase pathway solely accounts for the induction of cell cycle or antiapoptotic activity of the FGF recepto...

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Veröffentlicht in:	The Journal of biological chemistry 2004-12, Vol.279 (53), p.55348-55354
Hauptverfasser:	Zhang, Yongyou, Lin, Yongshun, Bowles, Courtney, Wang, Fen
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals CDC2-CDC28 Kinases - metabolism CDC2-CDC28 Kinases - physiology Cell Cycle Proteins - metabolism Cell Line Cyclin-Dependent Kinase Inhibitor p27 DNA, Complementary - metabolism G1 Phase Glutathione - metabolism Glutathione Transferase - metabolism Growth Substances - metabolism MAP Kinase Signaling System Membrane Proteins - metabolism Mice Models, Biological Mutation Phosphorylation Protein Binding Protein Structure, Tertiary Receptor Protein-Tyrosine Kinases - metabolism Receptor Protein-Tyrosine Kinases - physiology Receptor, Fibroblast Growth Factor, Type 1 Receptors, Fibroblast Growth Factor - metabolism Receptors, Fibroblast Growth Factor - physiology Recombinant Proteins - chemistry S Phase Sepharose - chemistry Signal Transduction Time Factors Tumor Suppressor Proteins - metabolism Tyrosine - metabolism Ubiquitin - metabolism
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