Molecular architecture of bacteriophage T4

In studying bacteriophage T4--one of the basic models of molecular biology for several decades--there has come a Renaissance, and this virus is now actively used as object of structural biology. The structures of six proteins of the phage particle have recently been determined at atomic resolution b...

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Veröffentlicht in:Biochemistry (Moscow) 2004-11, Vol.69 (11), p.1190-1202
Hauptverfasser: Mesyanzhinov, V V, Leiman, P G, Kostyuchenko, V A, Kurochkina, L P, Miroshnikov, K A, Sykilinda, N N, Shneider, M M
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container_end_page 1202
container_issue 11
container_start_page 1190
container_title Biochemistry (Moscow)
container_volume 69
creator Mesyanzhinov, V V
Leiman, P G
Kostyuchenko, V A
Kurochkina, L P
Miroshnikov, K A
Sykilinda, N N
Shneider, M M
description In studying bacteriophage T4--one of the basic models of molecular biology for several decades--there has come a Renaissance, and this virus is now actively used as object of structural biology. The structures of six proteins of the phage particle have recently been determined at atomic resolution by X-ray crystallography. Three-dimensional reconstruction of the infection device--one of the most complex multiprotein components--has been developed on the basis of cryo-electron microscopy images. The further study of bacteriophage T4 structure will allow a better understanding of the regulation of protein folding, assembly of biological structures, and also mechanisms of functioning of the complex biological molecular machines.
doi_str_mv 10.1007/PL00021751
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subjects Animals
Bacteriophage T4 - chemistry
Bacteriophage T4 - physiology
Bacteriophage T4 - ultrastructure
Bacteriophages
Crystallography
Molecular biology
Protein Conformation
Protein folding
Proteins
Viral Proteins - chemistry
Viral Proteins - physiology
Virus Assembly
Viruses
title Molecular architecture of bacteriophage T4
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