Abnormalities of apoptotic and cell cycle regulatory proteins in distinct histopathologic components of benign prostatic hyperplasia

Introduction:Benign prostatic hyperplasia (BPH) is a slowly progressive abnormal glandular enlargement with heterogeneous morphology. Disruption of apoptotic pathways has been suggested as an important regulatory mechanism in this common and significantly morbid disease. Methods:Prostatic tissue fro...

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Veröffentlicht in:	Prostate cancer and prostatic diseases 2004-12, Vol.7 (4), p.321-326
Hauptverfasser:	Gandour-Edwards, R, Mack, P C, deVere-White, R W, Gumerlock, P H
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Aged Aged, 80 and over Apoptosis BAX protein bcl-2-Associated X Protein Biomedicine Cancer Research Cell Cycle Cell Cycle Proteins - metabolism Cyclin-Dependent Kinase Inhibitor p27 Down-Regulation Enzyme Inhibitors - metabolism Epithelial Cells - metabolism Epithelium Gene expression Genes, Tumor Suppressor Genetic aspects Genital diseases Humans Hyperplasia Hypertrophy Immunoenzyme Techniques Immunohistochemistry Inflammation Male Middle Aged Nodules Prostate Prostate cancer Prostatectomy Prostatic Hyperplasia - metabolism Prostatic Hyperplasia - pathology Proteins Proto-Oncogene Proteins c-bcl-2 - metabolism Regulatory mechanisms (biology) Regulatory proteins Stromal Cells - metabolism Tumor Suppressor Proteins - metabolism
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