Effect of remifentanil hydrochloride administered via constant rate infusion on the minimum alveolar concentration of isoflurane in cats
To evaluate the effects of increasing doses of remifentanil hydrochloride administered via constant rate infusion (CRI) on the minimum alveolar concentration (MAC) of isoflurane in cats. 6 healthy adult cats. For each cat, 2 experiments were performed (2-week interval). On each study day, anesthesia...
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| Veröffentlicht in: | American journal of veterinary research 2009-05, Vol.70 (5), p.581-588 |
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| creator | Ferreira, Tatiana H Aguiar, Antonio J.A Valverde, Alexander Teixeira Neto, Francisco J Steagall, Paulo V.M Soares, Joao H.N |
| description | To evaluate the effects of increasing doses of remifentanil hydrochloride administered via constant rate infusion (CRI) on the minimum alveolar concentration (MAC) of isoflurane in cats.
6 healthy adult cats.
For each cat, 2 experiments were performed (2-week interval). On each study day, anesthesia was induced and maintained with isoflurane; a catheter was placed in a cephalic vein for the administration of lactated Ringer's solution or remifentanil CRIs, and a catheter was placed in the jugular vein for collection of blood samples for blood gas analyses. On the first study day, individual basal MAC (MAC(Basal)) was determined for each cat. On the second study day, 3 remifentanil CRIs (0.25, 0.5, and 1.0 microg/kg/min) were administered (in ascending order); for each infusion, at least 30 minutes elapsed before determination of MAC (designated as MAC(R0.25), MAC(R0.5), and MAC(R1.0), respectively). A 15-minute washout period was allowed between CRIs. A control MAC (MAC(Control)) was determined after the last remifentanil infusion.
Mean +/- SD MAC(Basal) and MAC(Control) values at sea level did not differ significantly (1.66 +/- 0.08% and 1.52 +/- 0.21%, respectively). The MAC values determined for each remifentanil CRI did not differ significantly. However, MAC(R0.25), MAC(R0.5), and MAC(R1.0) were significantly decreased, compared with MAC(Basal), by 23.4 +/- 7.9%, 29.8 +/- 8.3%, and 26.0 +/- 9.4%, respectively.
The 3 doses of remifentanil administered via CRI resulted in a similar degree of isoflurane MAC reduction in adult cats, indicating that a ceiling effect was achieved following administration of the lowest dose. |
| doi_str_mv | 10.2460/ajvr.70.5.581 |
| format | Article |
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6 healthy adult cats.
For each cat, 2 experiments were performed (2-week interval). On each study day, anesthesia was induced and maintained with isoflurane; a catheter was placed in a cephalic vein for the administration of lactated Ringer's solution or remifentanil CRIs, and a catheter was placed in the jugular vein for collection of blood samples for blood gas analyses. On the first study day, individual basal MAC (MAC(Basal)) was determined for each cat. On the second study day, 3 remifentanil CRIs (0.25, 0.5, and 1.0 microg/kg/min) were administered (in ascending order); for each infusion, at least 30 minutes elapsed before determination of MAC (designated as MAC(R0.25), MAC(R0.5), and MAC(R1.0), respectively). A 15-minute washout period was allowed between CRIs. A control MAC (MAC(Control)) was determined after the last remifentanil infusion.
Mean +/- SD MAC(Basal) and MAC(Control) values at sea level did not differ significantly (1.66 +/- 0.08% and 1.52 +/- 0.21%, respectively). The MAC values determined for each remifentanil CRI did not differ significantly. However, MAC(R0.25), MAC(R0.5), and MAC(R1.0) were significantly decreased, compared with MAC(Basal), by 23.4 +/- 7.9%, 29.8 +/- 8.3%, and 26.0 +/- 9.4%, respectively.
The 3 doses of remifentanil administered via CRI resulted in a similar degree of isoflurane MAC reduction in adult cats, indicating that a ceiling effect was achieved following administration of the lowest dose.</description><identifier>ISSN: 0002-9645</identifier><identifier>EISSN: 1943-5681</identifier><identifier>DOI: 10.2460/ajvr.70.5.581</identifier><identifier>PMID: 19405896</identifier><language>eng</language><publisher>United States</publisher><subject>analgesia ; anesthesia ; Anesthetics, Intravenous - administration & dosage ; Anesthetics, Intravenous - pharmacology ; Animals ; biomarkers ; Blood Gas Analysis ; cats ; Cats - metabolism ; chemical concentration ; combination drug therapy ; dosage ; dose response ; drug evaluation ; Female ; general anesthetics ; Infusions, Intravenous ; intravenous injection ; isoflurane ; Isoflurane - metabolism ; Male ; minimum alveolar concentration ; normal values ; opium alkaloids ; pharmacokinetics ; Piperidines - administration & dosage ; Piperidines - pharmacology ; pulmonary alveoli ; Pulmonary Alveoli - drug effects ; Pulmonary Alveoli - metabolism ; reference standards ; remifentanil ; remifentanil hydrochloride ; respiratory gases</subject><ispartof>American journal of veterinary research, 2009-05, Vol.70 (5), p.581-588</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-c93fc8df9e2ec23a484b49dd441858ce0809b66c977bb565265e56b0469edeb33</citedby><cites>FETCH-LOGICAL-c354t-c93fc8df9e2ec23a484b49dd441858ce0809b66c977bb565265e56b0469edeb33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19405896$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ferreira, Tatiana H</creatorcontrib><creatorcontrib>Aguiar, Antonio J.A</creatorcontrib><creatorcontrib>Valverde, Alexander</creatorcontrib><creatorcontrib>Teixeira Neto, Francisco J</creatorcontrib><creatorcontrib>Steagall, Paulo V.M</creatorcontrib><creatorcontrib>Soares, Joao H.N</creatorcontrib><title>Effect of remifentanil hydrochloride administered via constant rate infusion on the minimum alveolar concentration of isoflurane in cats</title><title>American journal of veterinary research</title><addtitle>Am J Vet Res</addtitle><description>To evaluate the effects of increasing doses of remifentanil hydrochloride administered via constant rate infusion (CRI) on the minimum alveolar concentration (MAC) of isoflurane in cats.
6 healthy adult cats.
For each cat, 2 experiments were performed (2-week interval). On each study day, anesthesia was induced and maintained with isoflurane; a catheter was placed in a cephalic vein for the administration of lactated Ringer's solution or remifentanil CRIs, and a catheter was placed in the jugular vein for collection of blood samples for blood gas analyses. On the first study day, individual basal MAC (MAC(Basal)) was determined for each cat. On the second study day, 3 remifentanil CRIs (0.25, 0.5, and 1.0 microg/kg/min) were administered (in ascending order); for each infusion, at least 30 minutes elapsed before determination of MAC (designated as MAC(R0.25), MAC(R0.5), and MAC(R1.0), respectively). A 15-minute washout period was allowed between CRIs. A control MAC (MAC(Control)) was determined after the last remifentanil infusion.
Mean +/- SD MAC(Basal) and MAC(Control) values at sea level did not differ significantly (1.66 +/- 0.08% and 1.52 +/- 0.21%, respectively). The MAC values determined for each remifentanil CRI did not differ significantly. However, MAC(R0.25), MAC(R0.5), and MAC(R1.0) were significantly decreased, compared with MAC(Basal), by 23.4 +/- 7.9%, 29.8 +/- 8.3%, and 26.0 +/- 9.4%, respectively.
The 3 doses of remifentanil administered via CRI resulted in a similar degree of isoflurane MAC reduction in adult cats, indicating that a ceiling effect was achieved following administration of the lowest dose.</description><subject>analgesia</subject><subject>anesthesia</subject><subject>Anesthetics, Intravenous - administration & dosage</subject><subject>Anesthetics, Intravenous - pharmacology</subject><subject>Animals</subject><subject>biomarkers</subject><subject>Blood Gas Analysis</subject><subject>cats</subject><subject>Cats - metabolism</subject><subject>chemical concentration</subject><subject>combination drug therapy</subject><subject>dosage</subject><subject>dose response</subject><subject>drug evaluation</subject><subject>Female</subject><subject>general anesthetics</subject><subject>Infusions, Intravenous</subject><subject>intravenous injection</subject><subject>isoflurane</subject><subject>Isoflurane - metabolism</subject><subject>Male</subject><subject>minimum alveolar concentration</subject><subject>normal values</subject><subject>opium alkaloids</subject><subject>pharmacokinetics</subject><subject>Piperidines - administration & dosage</subject><subject>Piperidines - pharmacology</subject><subject>pulmonary alveoli</subject><subject>Pulmonary Alveoli - drug effects</subject><subject>Pulmonary Alveoli - metabolism</subject><subject>reference standards</subject><subject>remifentanil</subject><subject>remifentanil hydrochloride</subject><subject>respiratory gases</subject><issn>0002-9645</issn><issn>1943-5681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0E1r3DAQBmBRWpptkmOvrU69eStZH5aOJaQfEOihyVnI0qirYFupJC_kH_RnR-4uFAbm8szL8CL0npJ9zyX5bB-PeT-QvdgLRV-hHdWcdUIq-hrtCCF9pyUXF-hdKY-E0F5R8RZdNESE0nKH_t6GAK7iFHCGOQZYql3ihA_PPid3mFKOHrD1c1xiqZDB42O02KWlNFhxthVwXMJaYlpwm3oAvOF5nbGdjpAmmzfuWnLD_1TAsaQwrdku2zF2tpYr9CbYqcD1eV-ih6-39zffu7uf337cfLnrHBO8dk6z4JQPGnpwPbNc8ZFr7zmnSigHRBE9Sun0MIyjkKKXAoQcCZcaPIyMXaJPp9ynnP6sUKqZY3EwTe2XtBYjB6qUoLzB7gRdTqVkCOYpx9nmZ0OJ2ao3W_VmIEaYVn3zH87B6ziD_6_PXTfw8QSCTcb-zrGYh189oYxQ2d7sGXsBuC2M4A</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Ferreira, Tatiana H</creator><creator>Aguiar, Antonio J.A</creator><creator>Valverde, Alexander</creator><creator>Teixeira Neto, Francisco J</creator><creator>Steagall, Paulo V.M</creator><creator>Soares, Joao H.N</creator><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090501</creationdate><title>Effect of remifentanil hydrochloride administered via constant rate infusion on the minimum alveolar concentration of isoflurane in cats</title><author>Ferreira, Tatiana H ; Aguiar, Antonio J.A ; Valverde, Alexander ; Teixeira Neto, Francisco J ; Steagall, Paulo V.M ; Soares, Joao H.N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-c93fc8df9e2ec23a484b49dd441858ce0809b66c977bb565265e56b0469edeb33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>analgesia</topic><topic>anesthesia</topic><topic>Anesthetics, Intravenous - administration & dosage</topic><topic>Anesthetics, Intravenous - pharmacology</topic><topic>Animals</topic><topic>biomarkers</topic><topic>Blood Gas Analysis</topic><topic>cats</topic><topic>Cats - metabolism</topic><topic>chemical concentration</topic><topic>combination drug therapy</topic><topic>dosage</topic><topic>dose response</topic><topic>drug evaluation</topic><topic>Female</topic><topic>general anesthetics</topic><topic>Infusions, Intravenous</topic><topic>intravenous injection</topic><topic>isoflurane</topic><topic>Isoflurane - metabolism</topic><topic>Male</topic><topic>minimum alveolar concentration</topic><topic>normal values</topic><topic>opium alkaloids</topic><topic>pharmacokinetics</topic><topic>Piperidines - administration & dosage</topic><topic>Piperidines - pharmacology</topic><topic>pulmonary alveoli</topic><topic>Pulmonary Alveoli - drug effects</topic><topic>Pulmonary Alveoli - metabolism</topic><topic>reference standards</topic><topic>remifentanil</topic><topic>remifentanil hydrochloride</topic><topic>respiratory gases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ferreira, Tatiana H</creatorcontrib><creatorcontrib>Aguiar, Antonio J.A</creatorcontrib><creatorcontrib>Valverde, Alexander</creatorcontrib><creatorcontrib>Teixeira Neto, Francisco J</creatorcontrib><creatorcontrib>Steagall, Paulo V.M</creatorcontrib><creatorcontrib>Soares, Joao H.N</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of veterinary research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ferreira, Tatiana H</au><au>Aguiar, Antonio J.A</au><au>Valverde, Alexander</au><au>Teixeira Neto, Francisco J</au><au>Steagall, Paulo V.M</au><au>Soares, Joao H.N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of remifentanil hydrochloride administered via constant rate infusion on the minimum alveolar concentration of isoflurane in cats</atitle><jtitle>American journal of veterinary research</jtitle><addtitle>Am J Vet Res</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>70</volume><issue>5</issue><spage>581</spage><epage>588</epage><pages>581-588</pages><issn>0002-9645</issn><eissn>1943-5681</eissn><abstract>To evaluate the effects of increasing doses of remifentanil hydrochloride administered via constant rate infusion (CRI) on the minimum alveolar concentration (MAC) of isoflurane in cats.
6 healthy adult cats.
For each cat, 2 experiments were performed (2-week interval). On each study day, anesthesia was induced and maintained with isoflurane; a catheter was placed in a cephalic vein for the administration of lactated Ringer's solution or remifentanil CRIs, and a catheter was placed in the jugular vein for collection of blood samples for blood gas analyses. On the first study day, individual basal MAC (MAC(Basal)) was determined for each cat. On the second study day, 3 remifentanil CRIs (0.25, 0.5, and 1.0 microg/kg/min) were administered (in ascending order); for each infusion, at least 30 minutes elapsed before determination of MAC (designated as MAC(R0.25), MAC(R0.5), and MAC(R1.0), respectively). A 15-minute washout period was allowed between CRIs. A control MAC (MAC(Control)) was determined after the last remifentanil infusion.
Mean +/- SD MAC(Basal) and MAC(Control) values at sea level did not differ significantly (1.66 +/- 0.08% and 1.52 +/- 0.21%, respectively). The MAC values determined for each remifentanil CRI did not differ significantly. However, MAC(R0.25), MAC(R0.5), and MAC(R1.0) were significantly decreased, compared with MAC(Basal), by 23.4 +/- 7.9%, 29.8 +/- 8.3%, and 26.0 +/- 9.4%, respectively.
The 3 doses of remifentanil administered via CRI resulted in a similar degree of isoflurane MAC reduction in adult cats, indicating that a ceiling effect was achieved following administration of the lowest dose.</abstract><cop>United States</cop><pmid>19405896</pmid><doi>10.2460/ajvr.70.5.581</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | analgesia anesthesia Anesthetics, Intravenous - administration & dosage Anesthetics, Intravenous - pharmacology Animals biomarkers Blood Gas Analysis cats Cats - metabolism chemical concentration combination drug therapy dosage dose response drug evaluation Female general anesthetics Infusions, Intravenous intravenous injection isoflurane Isoflurane - metabolism Male minimum alveolar concentration normal values opium alkaloids pharmacokinetics Piperidines - administration & dosage Piperidines - pharmacology pulmonary alveoli Pulmonary Alveoli - drug effects Pulmonary Alveoli - metabolism reference standards remifentanil remifentanil hydrochloride respiratory gases |
| title | Effect of remifentanil hydrochloride administered via constant rate infusion on the minimum alveolar concentration of isoflurane in cats |
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