PapA3 Is an Acyltransferase Required for Polyacyltrehalose Biosynthesis in Mycobacterium tuberculosis

Mycobacterium tuberculosis possesses an unusual cell wall that is replete with virulence-enhancing lipids. One cell wall molecule unique to pathogenic M. tuberculosis is polyacyltrehalose (PAT), a pentaacylated, trehalose-based glycolipid. Little is known about the biosynthesis of PAT, although its...

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Veröffentlicht in:	The Journal of biological chemistry 2009-05, Vol.284 (19), p.12745-12751
Hauptverfasser:	Hatzios, Stavroula K., Schelle, Michael W., Holsclaw, Cynthia M., Behrens, Christopher R., Botyanszki, Zsofia, Lin, Fiona L., Carlson, Brian L., Kumar, Pawan, Leary, Julie A., Bertozzi, Carolyn R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases - genetics Acyltransferases - metabolism Glycolipids - metabolism Lipoylation Mycobacterium tuberculosis Mycobacterium tuberculosis - enzymology Mycobacterium tuberculosis - genetics Palmitoyl Coenzyme A - metabolism Spectrometry, Mass, Electrospray Ionization Substrate Specificity Trehalose - analogs & derivatives Trehalose - metabolism
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