Successful treatment of Fusarium proliferatum pneumonia with posaconazole in a lung transplant recipient
A 62-year-old lung transplant recipient had Fusarium proliferatum pneumonia during itraconazole prophylaxis. Severe dyspnea and emphysema ensued, requiring supplemental oxygen therapy. Therapeutic options for this patient were limited; renal insufficiency and cyclosporine use precluded amphotericin...
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| Veröffentlicht in: | The Journal of heart and lung transplantation 2004-12, Vol.23 (12), p.1451-1454 |
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| container_issue | 12 |
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| container_title | The Journal of heart and lung transplantation |
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| creator | Herbrecht, Raoul Kessler, Romain Kravanja, Christine Meyer, Marie-Hélène Waller, Jocelyn Letscher-Bru, Valérie |
| description | A 62-year-old lung transplant recipient had
Fusarium proliferatum
pneumonia during itraconazole prophylaxis. Severe dyspnea and emphysema ensued, requiring supplemental oxygen therapy. Therapeutic options for this patient were limited; renal insufficiency and cyclosporine use precluded amphotericin B therapy, and susceptibility testing indicated that itraconazole and fluconazole had poor activity against
F proliferatum
. Treatment with posaconazole, a new triazole in clinical development for the prophylaxis and treatment of fungal infection, resulted in rapid clinical improvement and successful eradication of
F proliferatum
. Posaconazole may provide effective treatment for difficult-to-treat
Fusarium
infections. |
| doi_str_mv | 10.1016/j.healun.2003.09.033 |
| format | Article |
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Fusarium proliferatum
pneumonia during itraconazole prophylaxis. Severe dyspnea and emphysema ensued, requiring supplemental oxygen therapy. Therapeutic options for this patient were limited; renal insufficiency and cyclosporine use precluded amphotericin B therapy, and susceptibility testing indicated that itraconazole and fluconazole had poor activity against
F proliferatum
. Treatment with posaconazole, a new triazole in clinical development for the prophylaxis and treatment of fungal infection, resulted in rapid clinical improvement and successful eradication of
F proliferatum
. Posaconazole may provide effective treatment for difficult-to-treat
Fusarium
infections.</description><identifier>ISSN: 1053-2498</identifier><identifier>EISSN: 1557-3117</identifier><identifier>DOI: 10.1016/j.healun.2003.09.033</identifier><identifier>PMID: 15607679</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antifungal agents ; Antifungal Agents - therapeutic use ; Biological and medical sciences ; Fusarium ; Humans ; Lung Diseases, Fungal - drug therapy ; Lung Transplantation ; Male ; Medical sciences ; Middle Aged ; Opportunistic Infections - drug therapy ; Pharmacology. Drug treatments ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the heart ; Triazoles - therapeutic use</subject><ispartof>The Journal of heart and lung transplantation, 2004-12, Vol.23 (12), p.1451-1454</ispartof><rights>2004 International Society for Heart and Lung Transplantation</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-937654a7248001634edf5b968cac18d056e4ca5b587bde0eabbffdc5de4d76d93</citedby><cites>FETCH-LOGICAL-c390t-937654a7248001634edf5b968cac18d056e4ca5b587bde0eabbffdc5de4d76d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.healun.2003.09.033$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16390659$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15607679$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Herbrecht, Raoul</creatorcontrib><creatorcontrib>Kessler, Romain</creatorcontrib><creatorcontrib>Kravanja, Christine</creatorcontrib><creatorcontrib>Meyer, Marie-Hélène</creatorcontrib><creatorcontrib>Waller, Jocelyn</creatorcontrib><creatorcontrib>Letscher-Bru, Valérie</creatorcontrib><title>Successful treatment of Fusarium proliferatum pneumonia with posaconazole in a lung transplant recipient</title><title>The Journal of heart and lung transplantation</title><addtitle>J Heart Lung Transplant</addtitle><description>A 62-year-old lung transplant recipient had
Fusarium proliferatum
pneumonia during itraconazole prophylaxis. Severe dyspnea and emphysema ensued, requiring supplemental oxygen therapy. Therapeutic options for this patient were limited; renal insufficiency and cyclosporine use precluded amphotericin B therapy, and susceptibility testing indicated that itraconazole and fluconazole had poor activity against
F proliferatum
. Treatment with posaconazole, a new triazole in clinical development for the prophylaxis and treatment of fungal infection, resulted in rapid clinical improvement and successful eradication of
F proliferatum
. Posaconazole may provide effective treatment for difficult-to-treat
Fusarium
infections.</description><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Fusarium</subject><subject>Humans</subject><subject>Lung Diseases, Fungal - drug therapy</subject><subject>Lung Transplantation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Opportunistic Infections - drug therapy</subject><subject>Pharmacology. Drug treatments</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the heart</subject><subject>Triazoles - therapeutic use</subject><issn>1053-2498</issn><issn>1557-3117</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMGK1TAUhoMozjj6BiLZ6K41aZqk3QgyOCoMuFDX4TQ58ebSNjVpFH16c7kXZucqJ_Cdn_98hLzkrOWMq7fH9oAwl7XtGBMtG1smxCNyzaXUjeBcP64zk6Lp-nG4Is9yPjLGOiG7p-SKS8W00uM1OXwt1mLOvsx0Twj7gutOo6d3JUMKZaFbinPwmGA_fVYsS1wD0N9hP9AtZrBxhb9xRhpWCrQW-lGDYM3bDDUpoQ1bqJnPyRMPc8YXl_eGfL_78O32U3P_5ePn2_f3jRUj25tRaCV70F0_sHql6NF5OY1qsGD54JhU2FuQkxz05JAhTJP3zkqHvdPKjeKGvDnn1t4_C-bdLCFbnGsbjCUbpfmgO6Yq2J9Bm2LOCb3ZUlgg_TGcmZNhczRnw-Zk2LDRVMN17dUlv0wLuoeli9IKvL4AkC3MvrqwIT9wqt6p5Il7d-aw2vgVMJlsqyiLLlRpu3Ex_L_JP6jAnrI</recordid><startdate>20041201</startdate><enddate>20041201</enddate><creator>Herbrecht, Raoul</creator><creator>Kessler, Romain</creator><creator>Kravanja, Christine</creator><creator>Meyer, Marie-Hélène</creator><creator>Waller, Jocelyn</creator><creator>Letscher-Bru, Valérie</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041201</creationdate><title>Successful treatment of Fusarium proliferatum pneumonia with posaconazole in a lung transplant recipient</title><author>Herbrecht, Raoul ; Kessler, Romain ; Kravanja, Christine ; Meyer, Marie-Hélène ; Waller, Jocelyn ; Letscher-Bru, Valérie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-937654a7248001634edf5b968cac18d056e4ca5b587bde0eabbffdc5de4d76d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antifungal agents</topic><topic>Antifungal Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Fusarium</topic><topic>Humans</topic><topic>Lung Diseases, Fungal - drug therapy</topic><topic>Lung Transplantation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Opportunistic Infections - drug therapy</topic><topic>Pharmacology. Drug treatments</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the heart</topic><topic>Triazoles - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Herbrecht, Raoul</creatorcontrib><creatorcontrib>Kessler, Romain</creatorcontrib><creatorcontrib>Kravanja, Christine</creatorcontrib><creatorcontrib>Meyer, Marie-Hélène</creatorcontrib><creatorcontrib>Waller, Jocelyn</creatorcontrib><creatorcontrib>Letscher-Bru, Valérie</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of heart and lung transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Herbrecht, Raoul</au><au>Kessler, Romain</au><au>Kravanja, Christine</au><au>Meyer, Marie-Hélène</au><au>Waller, Jocelyn</au><au>Letscher-Bru, Valérie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful treatment of Fusarium proliferatum pneumonia with posaconazole in a lung transplant recipient</atitle><jtitle>The Journal of heart and lung transplantation</jtitle><addtitle>J Heart Lung Transplant</addtitle><date>2004-12-01</date><risdate>2004</risdate><volume>23</volume><issue>12</issue><spage>1451</spage><epage>1454</epage><pages>1451-1454</pages><issn>1053-2498</issn><eissn>1557-3117</eissn><abstract>A 62-year-old lung transplant recipient had
Fusarium proliferatum
pneumonia during itraconazole prophylaxis. Severe dyspnea and emphysema ensued, requiring supplemental oxygen therapy. Therapeutic options for this patient were limited; renal insufficiency and cyclosporine use precluded amphotericin B therapy, and susceptibility testing indicated that itraconazole and fluconazole had poor activity against
F proliferatum
. Treatment with posaconazole, a new triazole in clinical development for the prophylaxis and treatment of fungal infection, resulted in rapid clinical improvement and successful eradication of
F proliferatum
. Posaconazole may provide effective treatment for difficult-to-treat
Fusarium
infections.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15607679</pmid><doi>10.1016/j.healun.2003.09.033</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | The Journal of heart and lung transplantation, 2004-12, Vol.23 (12), p.1451-1454 |
| issn | 1053-2498 1557-3117 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - therapeutic use Biological and medical sciences Fusarium Humans Lung Diseases, Fungal - drug therapy Lung Transplantation Male Medical sciences Middle Aged Opportunistic Infections - drug therapy Pharmacology. Drug treatments Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Triazoles - therapeutic use |
| title | Successful treatment of Fusarium proliferatum pneumonia with posaconazole in a lung transplant recipient |
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