Metal-Free, Organocatalytic Asymmetric Transfer Hydrogenation of α,β-Unsaturated Aldehydes

Selective reduction without metals: An imidazolidinone salt effectively catalyzes the highly enantioselective biomimetic transfer hydrogenation of α,β‐unsaturated aldehydes to give the saturated analogues using a synthetic dihydropyridine cofactor (see scheme). Remarkably only one enantiomer forms r...

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Veröffentlicht in:	Angewandte Chemie International Edition 2004-12, Vol.44 (1), p.108-110
Hauptverfasser:	Yang, Jung Woon, Hechavarria Fonseca, Maria T., Vignola, Nicola, List, Benjamin
Format:	Artikel
Sprache:	eng
Schlagworte:	asymmetric catalysis chemoselectivity enantioselectivity hydrogenation organocatalysis
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description	Selective reduction without metals: An imidazolidinone salt effectively catalyzes the highly enantioselective biomimetic transfer hydrogenation of α,β‐unsaturated aldehydes to give the saturated analogues using a synthetic dihydropyridine cofactor (see scheme). Remarkably only one enantiomer forms regardless of the configuration of the enal starting material.
doi_str_mv	10.1002/anie.200462432
format	Article
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subjects	asymmetric catalysis chemoselectivity enantioselectivity hydrogenation organocatalysis
title	Metal-Free, Organocatalytic Asymmetric Transfer Hydrogenation of α,β-Unsaturated Aldehydes
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