Reduction of beta cell mass: partial insulin secretory compensation from the residual beta cell population in the nicotinamide-streptozotocin Göttingen minipig after oral glucose in vivo and in the perfused pancreas

A progressive loss of beta cell function and mass are important contributory factors in the development and progression of type 2 diabetes. The aim of this study was to evaluate the effects of a primary reduction in beta cell mass on beta cell function in vivo and in the perfused pancreas and to rel...

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Veröffentlicht in:	Diabetologia 2004-11, Vol.47 (11), p.1873-1878
Hauptverfasser:	LARSEN, M. O, ROLIN, B, GOTFREDSEN, C. F, CARR, R. D, HOLST, J. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Area Under Curve Biological and medical sciences Blood Glucose - metabolism Diabetes Mellitus, Experimental - pathology Diabetes. Impaired glucose tolerance Disease Models, Animal Dose-Response Relationship, Drug Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fasting Glucagon - pharmacology Glucagon-Like Peptide 1 Glucose - pharmacology Insulin - metabolism Insulin Secretion Islets of Langerhans - anatomy & histology Islets of Langerhans - drug effects Islets of Langerhans - metabolism Kinetics Male Medical sciences Niacinamide Pancreas - pathology Peptide Fragments - pharmacology Perfusion Protein Precursors - pharmacology Reference Values Swine Swine, Miniature
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