Electrical stimulation with a needle-type electrode inserted into the optic nerve in rabbit eyes
To investigate whether electrical stimulation of the optic nerve can elicit an electrical evoked potential (EEP) in rabbits and to determine whether such stimulation is a useful approach for the placement of a visual prosthesis. Two needle-type electrodes were inserted into the optic nerve using a t...
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| Veröffentlicht in: | Japanese journal of ophthalmology 2004-11, Vol.48 (6), p.552-557 |
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| container_title | Japanese journal of ophthalmology |
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| creator | Sakaguchi, Hirokazu Fujikado, Takashi Kanda, Hiroyuki Osanai, Makoto Fang, Xiaoyun Nakauchi, Kazuaki Ikuno, Yasushi Kamei, Motohiro Ohji, Masahito Yagi, Tetsuya Tano, Yasuo |
| description | To investigate whether electrical stimulation of the optic nerve can elicit an electrical evoked potential (EEP) in rabbits and to determine whether such stimulation is a useful approach for the placement of a visual prosthesis.
Two needle-type electrodes were inserted into the optic nerve using a transvitreal approach. For electrical stimulation, monophasic and biphasic pulses were used. By stimulating the optic nerve, the EEP was elicited. After evaluation of the EEP, a histological study was carried out.
When electrical stimulation was applied, the EEP could be recorded. The threshold with monophasic and biphasic stimulation was 10 +/- 0 microA and 20 +/- 8.2 microA, respectively. Histological examination revealed no major complications, such as bleeding or degeneration, which might have resulted from the insertion of electrodes or the electrical stimulation.
Electrical stimulation of the optic nerve can elicit an EEP, suggesting that this approach may be useful for a visual prosthesis system. |
| doi_str_mv | 10.1007/s10384-004-0114-7 |
| format | Article |
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Two needle-type electrodes were inserted into the optic nerve using a transvitreal approach. For electrical stimulation, monophasic and biphasic pulses were used. By stimulating the optic nerve, the EEP was elicited. After evaluation of the EEP, a histological study was carried out.
When electrical stimulation was applied, the EEP could be recorded. The threshold with monophasic and biphasic stimulation was 10 +/- 0 microA and 20 +/- 8.2 microA, respectively. Histological examination revealed no major complications, such as bleeding or degeneration, which might have resulted from the insertion of electrodes or the electrical stimulation.
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Two needle-type electrodes were inserted into the optic nerve using a transvitreal approach. For electrical stimulation, monophasic and biphasic pulses were used. By stimulating the optic nerve, the EEP was elicited. After evaluation of the EEP, a histological study was carried out.
When electrical stimulation was applied, the EEP could be recorded. The threshold with monophasic and biphasic stimulation was 10 +/- 0 microA and 20 +/- 8.2 microA, respectively. Histological examination revealed no major complications, such as bleeding or degeneration, which might have resulted from the insertion of electrodes or the electrical stimulation.
Electrical stimulation of the optic nerve can elicit an EEP, suggesting that this approach may be useful for a visual prosthesis system.</description><subject>Animals</subject><subject>Electric Stimulation - methods</subject><subject>Electrodes, Implanted - adverse effects</subject><subject>Evoked Potentials, Visual - physiology</subject><subject>Needles</subject><subject>Optic Nerve - pathology</subject><subject>Optic Nerve - physiology</subject><subject>Rabbits</subject><subject>Visual Cortex - physiology</subject><issn>0021-5155</issn><issn>1613-2246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkF1LwzAUhoMobk5_gDcSvPCumnPSNu2lyPyAgTe7j2l7yjK6diapsn9v5gaCF4e8JM97CA9j1yDuQQj14EHIIk2EiAOQJuqETSEHmSCm-SmbCoGQZJBlE3bh_VpEECWes0m8KlGpcso-5h3VwdnadNwHuxk7E-zQ828bVtzwnqjpKAm7LXH6JYeGuO09uUBNDGHgYUV82AZbR9p97V-5M1VlA6cd-Ut21prO09XxnLHl83z59Jos3l_enh4XSS0zEZKqKQjLtDSoqFVxmhwBMVdVlas2qwFiQKQsVW0hsaXaVJhhDLElpJyxu8ParRs-R_JBb6yvqetMT8Poda6gAJVhBG__gethdH38mkYJCEWJewgOUO0G7x21euvsxridBqH36vVBvY5G9V69VrFzc1w8Vhtq_hpH1_IHPGx_IQ</recordid><startdate>200411</startdate><enddate>200411</enddate><creator>Sakaguchi, Hirokazu</creator><creator>Fujikado, Takashi</creator><creator>Kanda, Hiroyuki</creator><creator>Osanai, Makoto</creator><creator>Fang, Xiaoyun</creator><creator>Nakauchi, Kazuaki</creator><creator>Ikuno, Yasushi</creator><creator>Kamei, Motohiro</creator><creator>Ohji, Masahito</creator><creator>Yagi, Tetsuya</creator><creator>Tano, Yasuo</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200411</creationdate><title>Electrical stimulation with a needle-type electrode inserted into the optic nerve in rabbit eyes</title><author>Sakaguchi, Hirokazu ; 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Two needle-type electrodes were inserted into the optic nerve using a transvitreal approach. For electrical stimulation, monophasic and biphasic pulses were used. By stimulating the optic nerve, the EEP was elicited. After evaluation of the EEP, a histological study was carried out.
When electrical stimulation was applied, the EEP could be recorded. The threshold with monophasic and biphasic stimulation was 10 +/- 0 microA and 20 +/- 8.2 microA, respectively. Histological examination revealed no major complications, such as bleeding or degeneration, which might have resulted from the insertion of electrodes or the electrical stimulation.
Electrical stimulation of the optic nerve can elicit an EEP, suggesting that this approach may be useful for a visual prosthesis system.</abstract><cop>Japan</cop><pub>Springer Nature B.V</pub><pmid>15592779</pmid><doi>10.1007/s10384-004-0114-7</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Electric Stimulation - methods Electrodes, Implanted - adverse effects Evoked Potentials, Visual - physiology Needles Optic Nerve - pathology Optic Nerve - physiology Rabbits Visual Cortex - physiology |
| title | Electrical stimulation with a needle-type electrode inserted into the optic nerve in rabbit eyes |
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