SURROGATE MARKERS PREDICT ANGIOGENIC POTENTIAL AND SURVIVAL IN PATIENTS WITH GLIOBLASTOMA MULTIFORME

Abstract OBJECTIVE The neovascularization of malignant brain tumors is a poorly understood phenomenon. Radiographic and histological evidence of increased vascularity correlate with clinical grade of gliomas. However, a quantitative noninvasive assay to assess glioma vascularity and associated clini...

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Veröffentlicht in:	Neurosurgery 2009-05, Vol.64 (5), p.819-827
Hauptverfasser:	Greenfield, Jeffrey P., Jin, David K., Young, Lauren M., Christos, Paul J., Abrey, Lauren, Rafii, Shahin, Gutin, Philip H.
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen Adult Aged Aged, 80 and over Antigens, CD - metabolism Biological and medical sciences Biological Assay - methods Biomarkers, Tumor - metabolism Blood Bone marrow Brain cancer Brain Neoplasms - blood Brain Neoplasms - mortality Brain Neoplasms - pathology Endothelial Cells - metabolism Endothelial Cells - pathology Enzyme-Linked Immunosorbent Assay - methods Female Flow Cytometry Follow-Up Studies Glioblastoma - blood Glioblastoma - mortality Glioblastoma - pathology Glioma Glycoproteins - metabolism Humans Male Medical prognosis Medical sciences Middle Aged Neovascularization, Pathologic - blood Neurosurgery Peptides - metabolism Plasma Stem Cells - metabolism Stem Cells - pathology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Umbilical Veins - pathology Vascular endothelial growth factor Vascular Endothelial Growth Factor Receptor-2 - metabolism
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