Osteogenic Differentiation of Bone Marrow Stromal Cells Induced by Coculture with Chondrocytes Encapsulated in Three-Dimensional Matrices

Endochondral ossification implicates chondrocyte signaling as an important factor in directing the osteogenic differentiation of mesenchymal stem cells in vivo . In this study, the osteoinductive capabilities of articular chondrocytes suspended in alginate hydrogels were analyzed via coculture with...

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Veröffentlicht in:	Tissue engineering. Part A 2009-05, Vol.15 (5), p.1181-1190
Hauptverfasser:	Thompson, Andrew D., Betz, Martha W., Yoon, Diana M., Fisher, John P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alginates Alkaline Phosphatase - genetics Animals Base Sequence Biocompatible Materials Bone marrow Bone Marrow Cells - cytology Bone Marrow Cells - metabolism Bone Morphogenetic Protein 2 - genetics Calcium - metabolism Cell culture Cell Differentiation Cells, Cultured Chondrocytes - cytology Chondrocytes - metabolism Coculture Techniques DNA Primers - genetics Glucuronic Acid Hexuronic Acids Hydrogels Osteocalcin - genetics Osteogenesis - genetics Osteogenesis - physiology Rats RNA, Messenger - genetics RNA, Messenger - metabolism Signal transduction Stem cells Stromal Cells - cytology Stromal Cells - metabolism Time Factors Tissue engineering Tissue Engineering - methods Tissue Scaffolds
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