Efficacy and tolerability of cancer pain management with controlled-release oxycodone tablets in opioid-naive cancer pain patients, starting with 5 mg tablets
We conducted an open-label, dose titration study to assess the efficacy and tolerability of controlled-release oxycodone in the therapy of cancer pain management, starting with a newly developed 5 mg tablet every 12 h. Twenty-two Japanese cancer patients with pain who had not been taking opioid anal...
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Veröffentlicht in: | Japanese journal of clinical oncology 2004-10, Vol.34 (10), p.608-614 |
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creator | Koizumi, Wasaburo Toma, Hiroshi Watanabe, Ken-ichi Katayama, Kanji Kawahara, Masaaki Matsui, Kaoru Takiuchi, Hiroya Yoshino, Kunitoshi Araki, Nobuhito Kodama, Ken Kimura, Hideyuki Kono, Ichiro Hasegawa, Hiroyasu Hatanaka, Kaoru Hiraga, Kazuaki Takeda, Fumikazu |
description | We conducted an open-label, dose titration study to assess the efficacy and tolerability of controlled-release oxycodone in the therapy of cancer pain management, starting with a newly developed 5 mg tablet every 12 h.
Twenty-two Japanese cancer patients with pain who had not been taking opioid analgesics over the previous 2 weeks were enrolled. The length of time and the dose needed to attain stable and adequate pain control were evaluated in addition to the assessment of analgesic efficacy and safety during the study period.
Eighteen patients in the efficacy population (18 out of 20, 90%) attained stable, adequate pain control. Two-thirds of the patients attained stable, adequate pain control without any dose titration. The mean length of time was 1.2 days. In these patients, the pain was significantly reduced in intensity, even at 1 h after the initial dose intake. Fifteen patients (68%) reported at least one side effect, but only one patient had to withdraw from the study because of a side effect.
The results suggest that controlled-release oxycodone tablets offered stable and adequate pain control within a short period of time in most Japanese cancer patients who have not been taking opioid analgesics, and could be effectively titrated against pain from a starting dose of 5 mg every 12 h. This indicates that a lower strength controlled-release oxycodone formulation may make it possible to start and titrate the dose more appropriately and carefully in patients who are sensitive to opioid analgesics. |
doi_str_mv | 10.1093/jjco/hyh104 |
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Twenty-two Japanese cancer patients with pain who had not been taking opioid analgesics over the previous 2 weeks were enrolled. The length of time and the dose needed to attain stable and adequate pain control were evaluated in addition to the assessment of analgesic efficacy and safety during the study period.
Eighteen patients in the efficacy population (18 out of 20, 90%) attained stable, adequate pain control. Two-thirds of the patients attained stable, adequate pain control without any dose titration. The mean length of time was 1.2 days. In these patients, the pain was significantly reduced in intensity, even at 1 h after the initial dose intake. Fifteen patients (68%) reported at least one side effect, but only one patient had to withdraw from the study because of a side effect.
The results suggest that controlled-release oxycodone tablets offered stable and adequate pain control within a short period of time in most Japanese cancer patients who have not been taking opioid analgesics, and could be effectively titrated against pain from a starting dose of 5 mg every 12 h. This indicates that a lower strength controlled-release oxycodone formulation may make it possible to start and titrate the dose more appropriately and carefully in patients who are sensitive to opioid analgesics.</description><identifier>ISSN: 0368-2811</identifier><identifier>ISSN: 1465-3621</identifier><identifier>EISSN: 1465-3621</identifier><identifier>DOI: 10.1093/jjco/hyh104</identifier><identifier>PMID: 15591459</identifier><language>eng</language><publisher>England: Oxford Publishing Limited (England)</publisher><subject>Aged ; Aged, 80 and over ; Analgesics, Opioid - administration & dosage ; Delayed-Action Preparations ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Female ; Humans ; Lung Neoplasms - physiopathology ; Male ; Middle Aged ; Neoplasms - physiopathology ; Oxycodone - administration & dosage ; Pain Measurement - methods ; Pain, Intractable - drug therapy ; Patient Acceptance of Health Care ; Stomach Neoplasms - physiopathology ; Tablets ; Titrimetry</subject><ispartof>Japanese journal of clinical oncology, 2004-10, Vol.34 (10), p.608-614</ispartof><rights>Copyright Oxford University Press(England) Oct 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c254t-f07cf65ab0b3c5d2f0db3fe2fe6af1d0fc67198c4bad98d94e593e2fdb0301bc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15591459$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koizumi, Wasaburo</creatorcontrib><creatorcontrib>Toma, Hiroshi</creatorcontrib><creatorcontrib>Watanabe, Ken-ichi</creatorcontrib><creatorcontrib>Katayama, Kanji</creatorcontrib><creatorcontrib>Kawahara, Masaaki</creatorcontrib><creatorcontrib>Matsui, Kaoru</creatorcontrib><creatorcontrib>Takiuchi, Hiroya</creatorcontrib><creatorcontrib>Yoshino, Kunitoshi</creatorcontrib><creatorcontrib>Araki, Nobuhito</creatorcontrib><creatorcontrib>Kodama, Ken</creatorcontrib><creatorcontrib>Kimura, Hideyuki</creatorcontrib><creatorcontrib>Kono, Ichiro</creatorcontrib><creatorcontrib>Hasegawa, Hiroyasu</creatorcontrib><creatorcontrib>Hatanaka, Kaoru</creatorcontrib><creatorcontrib>Hiraga, Kazuaki</creatorcontrib><creatorcontrib>Takeda, Fumikazu</creatorcontrib><title>Efficacy and tolerability of cancer pain management with controlled-release oxycodone tablets in opioid-naive cancer pain patients, starting with 5 mg tablets</title><title>Japanese journal of clinical oncology</title><addtitle>Jpn J Clin Oncol</addtitle><description>We conducted an open-label, dose titration study to assess the efficacy and tolerability of controlled-release oxycodone in the therapy of cancer pain management, starting with a newly developed 5 mg tablet every 12 h.
Twenty-two Japanese cancer patients with pain who had not been taking opioid analgesics over the previous 2 weeks were enrolled. The length of time and the dose needed to attain stable and adequate pain control were evaluated in addition to the assessment of analgesic efficacy and safety during the study period.
Eighteen patients in the efficacy population (18 out of 20, 90%) attained stable, adequate pain control. Two-thirds of the patients attained stable, adequate pain control without any dose titration. The mean length of time was 1.2 days. In these patients, the pain was significantly reduced in intensity, even at 1 h after the initial dose intake. Fifteen patients (68%) reported at least one side effect, but only one patient had to withdraw from the study because of a side effect.
The results suggest that controlled-release oxycodone tablets offered stable and adequate pain control within a short period of time in most Japanese cancer patients who have not been taking opioid analgesics, and could be effectively titrated against pain from a starting dose of 5 mg every 12 h. This indicates that a lower strength controlled-release oxycodone formulation may make it possible to start and titrate the dose more appropriately and carefully in patients who are sensitive to opioid analgesics.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analgesics, Opioid - administration & dosage</subject><subject>Delayed-Action Preparations</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Humans</subject><subject>Lung Neoplasms - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasms - physiopathology</subject><subject>Oxycodone - administration & dosage</subject><subject>Pain Measurement - methods</subject><subject>Pain, Intractable - drug therapy</subject><subject>Patient Acceptance of Health Care</subject><subject>Stomach Neoplasms - physiopathology</subject><subject>Tablets</subject><subject>Titrimetry</subject><issn>0368-2811</issn><issn>1465-3621</issn><issn>1465-3621</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1v1DAQQC1ERZfCiTuyOPRSQu04TuIjqsqHVKkXOEcTe7zrlWMH20ubP8NvJdUuQnCaw7x5GukR8oazD5wpcb3f63i9W3acNc_IhjetrERb8-dkw0TbV3XP-Tl5mfOeMSb7pntBzrmUijdSbcivW2udBr1QCIaW6DHB6LwrC42WaggaE53BBTpBgC1OGAp9cGVHdQwlRe_RVAk9QkYaHxcdTQxIC4weS6brXZxddKYK4H7iP8IZiltt-T3NBVJxYXsUSzpt_whekTMLPuPr07wg3z_dfrv5Ut3df_568_Gu0rVsSmVZp20rYWSj0NLUlplRWKwttmC5YVa3HVe9bkYwqjeqQanEujYjE4yPWlyQy6N3TvHHAXMZJpc1eg8B4yEP63nXK9Ws4Lv_wH08pLD-NtS841yqrl2hqyOkU8w5oR3m5CZIy8DZ8NRseGo2HJut9NuT8jBOaP6yp0jiNw2cmAo</recordid><startdate>200410</startdate><enddate>200410</enddate><creator>Koizumi, Wasaburo</creator><creator>Toma, Hiroshi</creator><creator>Watanabe, Ken-ichi</creator><creator>Katayama, Kanji</creator><creator>Kawahara, Masaaki</creator><creator>Matsui, Kaoru</creator><creator>Takiuchi, Hiroya</creator><creator>Yoshino, Kunitoshi</creator><creator>Araki, Nobuhito</creator><creator>Kodama, Ken</creator><creator>Kimura, Hideyuki</creator><creator>Kono, Ichiro</creator><creator>Hasegawa, Hiroyasu</creator><creator>Hatanaka, Kaoru</creator><creator>Hiraga, Kazuaki</creator><creator>Takeda, Fumikazu</creator><general>Oxford Publishing Limited (England)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200410</creationdate><title>Efficacy and tolerability of cancer pain management with controlled-release oxycodone tablets in opioid-naive cancer pain patients, starting with 5 mg tablets</title><author>Koizumi, Wasaburo ; 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Twenty-two Japanese cancer patients with pain who had not been taking opioid analgesics over the previous 2 weeks were enrolled. The length of time and the dose needed to attain stable and adequate pain control were evaluated in addition to the assessment of analgesic efficacy and safety during the study period.
Eighteen patients in the efficacy population (18 out of 20, 90%) attained stable, adequate pain control. Two-thirds of the patients attained stable, adequate pain control without any dose titration. The mean length of time was 1.2 days. In these patients, the pain was significantly reduced in intensity, even at 1 h after the initial dose intake. Fifteen patients (68%) reported at least one side effect, but only one patient had to withdraw from the study because of a side effect.
The results suggest that controlled-release oxycodone tablets offered stable and adequate pain control within a short period of time in most Japanese cancer patients who have not been taking opioid analgesics, and could be effectively titrated against pain from a starting dose of 5 mg every 12 h. This indicates that a lower strength controlled-release oxycodone formulation may make it possible to start and titrate the dose more appropriately and carefully in patients who are sensitive to opioid analgesics.</abstract><cop>England</cop><pub>Oxford Publishing Limited (England)</pub><pmid>15591459</pmid><doi>10.1093/jjco/hyh104</doi><tpages>7</tpages></addata></record> |
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source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Freely Accessible Japanese Titles |
subjects | Aged Aged, 80 and over Analgesics, Opioid - administration & dosage Delayed-Action Preparations Dose-Response Relationship, Drug Drug Administration Schedule Female Humans Lung Neoplasms - physiopathology Male Middle Aged Neoplasms - physiopathology Oxycodone - administration & dosage Pain Measurement - methods Pain, Intractable - drug therapy Patient Acceptance of Health Care Stomach Neoplasms - physiopathology Tablets Titrimetry |
title | Efficacy and tolerability of cancer pain management with controlled-release oxycodone tablets in opioid-naive cancer pain patients, starting with 5 mg tablets |
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