Porcine Small Intestine Submucosa for Soft Tissue Augmentation
Objective. Porcine small intestine submucosa was evaluated as a material for soft tissue augmentation in the hairless guinea pig model. Materials and Methods. Small intestine submucosa was formed into strips and rolls and implanted into the dorsum of the hairless guinea pig. The animals were divided...
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| Veröffentlicht in: | Dermatologic surgery 2004-12, Vol.30 (12p1), p.1486-1490 |
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| creator | Spiegel, Jeffrey H. Egan, Timothy J. |
| description | Objective. Porcine small intestine submucosa was evaluated as a material for soft tissue augmentation in the hairless guinea pig model.
Materials and Methods. Small intestine submucosa was formed into strips and rolls and implanted into the dorsum of the hairless guinea pig. The animals were divided into three groups and the implants were evaluated grossly and microscopically for persistence, infection, and inflammation. A total of 116 implants were evaluated grossly.
Results. Selected samples from the 1‐ and 3‐month cohorts and all identifiable samples from the 5‐month cohort were evaluated microscopically. Some implants were not located, likely due to migration. With one exception, the identified implants in the 5‐month cohort exhibited minimal inflammation and appeared well tolerated. The eight‐ply small intestine submucosa material appears well tolerated and provided increased soft tissue volume at 5 months.
Conclusion. Small intestine submucosa may represent an alternative to autologous and homologous materials for soft tissue augmentation. |
| doi_str_mv | 10.1111/j.1524-4725.2004.30507.x |
| format | Article |
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Materials and Methods. Small intestine submucosa was formed into strips and rolls and implanted into the dorsum of the hairless guinea pig. The animals were divided into three groups and the implants were evaluated grossly and microscopically for persistence, infection, and inflammation. A total of 116 implants were evaluated grossly.
Results. Selected samples from the 1‐ and 3‐month cohorts and all identifiable samples from the 5‐month cohort were evaluated microscopically. Some implants were not located, likely due to migration. With one exception, the identified implants in the 5‐month cohort exhibited minimal inflammation and appeared well tolerated. The eight‐ply small intestine submucosa material appears well tolerated and provided increased soft tissue volume at 5 months.
Conclusion. Small intestine submucosa may represent an alternative to autologous and homologous materials for soft tissue augmentation.</description><identifier>ISSN: 1076-0512</identifier><identifier>EISSN: 1524-4725</identifier><identifier>DOI: 10.1111/j.1524-4725.2004.30507.x</identifier><identifier>PMID: 15606736</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Inc</publisher><subject>Animals ; Biological and medical sciences ; Biological Dressings ; Dermatologic Surgical Procedures ; Dermatology ; Female ; Graft Survival ; Guinea Pigs ; Intestinal Mucosa - pathology ; Intestinal Mucosa - transplantation ; Intestine, Small - pathology ; Intestine, Small - transplantation ; Male ; Medical sciences ; Models, Animal ; Skin - pathology ; Skin plastic surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Swine ; Transplantation, Heterologous</subject><ispartof>Dermatologic surgery, 2004-12, Vol.30 (12p1), p.1486-1490</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3987-14f7f5263bd287a708abcd5e20022a3ff2e36c55563364ffa5aeeb6b7bbf40db3</citedby><cites>FETCH-LOGICAL-c3987-14f7f5263bd287a708abcd5e20022a3ff2e36c55563364ffa5aeeb6b7bbf40db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1524-4725.2004.30507.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1524-4725.2004.30507.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16385434$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15606736$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spiegel, Jeffrey H.</creatorcontrib><creatorcontrib>Egan, Timothy J.</creatorcontrib><title>Porcine Small Intestine Submucosa for Soft Tissue Augmentation</title><title>Dermatologic surgery</title><addtitle>Dermatol Surg</addtitle><description>Objective. Porcine small intestine submucosa was evaluated as a material for soft tissue augmentation in the hairless guinea pig model.
Materials and Methods. Small intestine submucosa was formed into strips and rolls and implanted into the dorsum of the hairless guinea pig. The animals were divided into three groups and the implants were evaluated grossly and microscopically for persistence, infection, and inflammation. A total of 116 implants were evaluated grossly.
Results. Selected samples from the 1‐ and 3‐month cohorts and all identifiable samples from the 5‐month cohort were evaluated microscopically. Some implants were not located, likely due to migration. With one exception, the identified implants in the 5‐month cohort exhibited minimal inflammation and appeared well tolerated. The eight‐ply small intestine submucosa material appears well tolerated and provided increased soft tissue volume at 5 months.
Conclusion. Small intestine submucosa may represent an alternative to autologous and homologous materials for soft tissue augmentation.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biological Dressings</subject><subject>Dermatologic Surgical Procedures</subject><subject>Dermatology</subject><subject>Female</subject><subject>Graft Survival</subject><subject>Guinea Pigs</subject><subject>Intestinal Mucosa - pathology</subject><subject>Intestinal Mucosa - transplantation</subject><subject>Intestine, Small - pathology</subject><subject>Intestine, Small - transplantation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Models, Animal</subject><subject>Skin - pathology</subject><subject>Skin plastic surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Swine</subject><subject>Transplantation, Heterologous</subject><issn>1076-0512</issn><issn>1524-4725</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtOAjEUhhujEURfwcxGdzP23mFDQvBGQqIJsG46pTVD5oLtTIS3twMT2dpNT9PvnP79AIgQTFBYT9sEMUxjKjBLMIQ0IZBBkewvwPDv4jLUUPAYMoQH4Mb7LYQIjwm8BgPEOOSC8CGYfNZO55WJlqUqimheNcY3x3Obla2uvYps7aJlbZtolXvfmmjafpWmalST19UtuLKq8Oau30dg_fqymr3Hi4-3-Wy6iDUZpyJG1ArLMCfZBqdCCZiqTG-YCdkxVsRabAjXjDFOCKfWKqaMyXgmssxSuMnICDye5u5c_d2GiLLMvTZFoSpTt15ygUQ6JjiA6QnUrvbeGSt3Li-VO0gEZedObmWnSHaKZOdOHt3JfWi9798IXzebc2MvKwAPPaC8VoV1qtK5P3OcpIwSGrjJifvJC3P4dwD5vFwfS_ILctOKGw</recordid><startdate>200412</startdate><enddate>200412</enddate><creator>Spiegel, Jeffrey H.</creator><creator>Egan, Timothy J.</creator><general>Blackwell Science Inc</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200412</creationdate><title>Porcine Small Intestine Submucosa for Soft Tissue Augmentation</title><author>Spiegel, Jeffrey H. ; Egan, Timothy J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3987-14f7f5263bd287a708abcd5e20022a3ff2e36c55563364ffa5aeeb6b7bbf40db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biological Dressings</topic><topic>Dermatologic Surgical Procedures</topic><topic>Dermatology</topic><topic>Female</topic><topic>Graft Survival</topic><topic>Guinea Pigs</topic><topic>Intestinal Mucosa - pathology</topic><topic>Intestinal Mucosa - transplantation</topic><topic>Intestine, Small - pathology</topic><topic>Intestine, Small - transplantation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Models, Animal</topic><topic>Skin - pathology</topic><topic>Skin plastic surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Swine</topic><topic>Transplantation, Heterologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spiegel, Jeffrey H.</creatorcontrib><creatorcontrib>Egan, Timothy J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Dermatologic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Spiegel, Jeffrey H.</au><au>Egan, Timothy J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Porcine Small Intestine Submucosa for Soft Tissue Augmentation</atitle><jtitle>Dermatologic surgery</jtitle><addtitle>Dermatol Surg</addtitle><date>2004-12</date><risdate>2004</risdate><volume>30</volume><issue>12p1</issue><spage>1486</spage><epage>1490</epage><pages>1486-1490</pages><issn>1076-0512</issn><eissn>1524-4725</eissn><abstract>Objective. Porcine small intestine submucosa was evaluated as a material for soft tissue augmentation in the hairless guinea pig model.
Materials and Methods. Small intestine submucosa was formed into strips and rolls and implanted into the dorsum of the hairless guinea pig. The animals were divided into three groups and the implants were evaluated grossly and microscopically for persistence, infection, and inflammation. A total of 116 implants were evaluated grossly.
Results. Selected samples from the 1‐ and 3‐month cohorts and all identifiable samples from the 5‐month cohort were evaluated microscopically. Some implants were not located, likely due to migration. With one exception, the identified implants in the 5‐month cohort exhibited minimal inflammation and appeared well tolerated. The eight‐ply small intestine submucosa material appears well tolerated and provided increased soft tissue volume at 5 months.
Conclusion. Small intestine submucosa may represent an alternative to autologous and homologous materials for soft tissue augmentation.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Inc</pub><pmid>15606736</pmid><doi>10.1111/j.1524-4725.2004.30507.x</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Journals@Ovid Complete; Access via Wiley Online Library |
| subjects | Animals Biological and medical sciences Biological Dressings Dermatologic Surgical Procedures Dermatology Female Graft Survival Guinea Pigs Intestinal Mucosa - pathology Intestinal Mucosa - transplantation Intestine, Small - pathology Intestine, Small - transplantation Male Medical sciences Models, Animal Skin - pathology Skin plastic surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Swine Transplantation, Heterologous |
| title | Porcine Small Intestine Submucosa for Soft Tissue Augmentation |
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