Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis

Progression of tumors to invasive and metastatic forms requires that tumor cells undergo dramatic morphologic changes, a process regulated by Rho GTPases. Elevated expression of RhoA and RhoC, as well as the Rho effector proteins ROCK I and ROCK II, are commonly observed in human cancers and are oft...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2004-12, Vol.64 (24), p.8994-9001
Hauptverfasser:	CROFT, Daniel R, SAHAI, Erik, MAVRIA, Georgia, SHUIXING LI, TSAI, Jeff, LEE, William M. F, MARSHALL, Christopher J, OLSON, Michael F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Colonic Neoplasms - blood supply Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Cytoskeleton - enzymology Cytoskeleton - pathology Enzyme Activation HCT116 Cells Humans Hyaluronan Receptors - metabolism Intracellular Signaling Peptides and Proteins Male Medical sciences Mice Mice, Nude Neoplasm Invasiveness Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Pharmacology. Drug treatments Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism rho-Associated Kinases Tamoxifen - analogs & derivatives Tamoxifen - pharmacology
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