Comparison of intravenous and peritonsillar infiltration of tramadol for postoperative pain relief in children following adenotonsillectomy

BACKGROUND AND OBJECTIVEThe aim of this study was to compare the postoperative analgesic efficacy and side-effects of intravenous tramadol with peritonsillar infiltration of tramadol in children undergoing adenotonsillectomy. METHODSSixty-six children were randomized into two groupsgroup I received...

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Veröffentlicht in:European journal of anaesthesiology 2009-04, Vol.26 (4), p.333-337
Hauptverfasser: Akkaya, Taylan, Bedirli, Nurdan, Ceylan, Tijen, Matkap, Erkan, Gulen, Guven, Elverici, Ozan, Gumus, Haluk, Akin, Istemihan
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container_end_page 337
container_issue 4
container_start_page 333
container_title European journal of anaesthesiology
container_volume 26
creator Akkaya, Taylan
Bedirli, Nurdan
Ceylan, Tijen
Matkap, Erkan
Gulen, Guven
Elverici, Ozan
Gumus, Haluk
Akin, Istemihan
description BACKGROUND AND OBJECTIVEThe aim of this study was to compare the postoperative analgesic efficacy and side-effects of intravenous tramadol with peritonsillar infiltration of tramadol in children undergoing adenotonsillectomy. METHODSSixty-six children were randomized into two groupsgroup I received 2 mg kg tramadol intravenously and group II received 2 mg kg tramadol in 2 ml of normal saline (1 ml per tonsil) via peritonsillar infiltration. Modified Hannallah pain scale, nausea, vomiting, bleeding, rescue analgesia, sedation and Aldrete scores were recorded at the 1st, 15th, 30th and 60th minute postoperatively. The Aldrete score was used to determine the postanaesthesia care unit discharge criteria. Patients were evaluated for the analgesic requirement, nausea and vomiting, bleeding and sedation. RESULTSThere were no differences between groups during the first 1 h. In the postanaesthesia care unit, groups I and II had comparable pain scores that were not statistically significant (P > 0.05). But during the first 24 h the additional analgesic requirement of group I (141.81 mg) was more than group II (83.63 mg) (P = 0.002). Pain scores in the postoperative ward at 6, 12 and 24 h were significantly higher in group I than in group II (P < 0.001). Also four patients (12.12%) from group I and one patient (3.05%) from group II had nausea and vomiting in the postanaesthesia care unit and none of the patients had rescue analgesics. There were no differences between groups regarding nausea and vomiting, sedation and bleeding in the postoperative ward. CONCLUSIONIn adenotonsillectomy cases, peritonsillar infiltration of tramadol maintains efficient pain relief with lower incidence of nausea and vomiting.
doi_str_mv 10.1097/EJA.0b013e32831c8988
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METHODSSixty-six children were randomized into two groupsgroup I received 2 mg kg tramadol intravenously and group II received 2 mg kg tramadol in 2 ml of normal saline (1 ml per tonsil) via peritonsillar infiltration. Modified Hannallah pain scale, nausea, vomiting, bleeding, rescue analgesia, sedation and Aldrete scores were recorded at the 1st, 15th, 30th and 60th minute postoperatively. The Aldrete score was used to determine the postanaesthesia care unit discharge criteria. Patients were evaluated for the analgesic requirement, nausea and vomiting, bleeding and sedation. RESULTSThere were no differences between groups during the first 1 h. In the postanaesthesia care unit, groups I and II had comparable pain scores that were not statistically significant (P &gt; 0.05). But during the first 24 h the additional analgesic requirement of group I (141.81 mg) was more than group II (83.63 mg) (P = 0.002). Pain scores in the postoperative ward at 6, 12 and 24 h were significantly higher in group I than in group II (P &lt; 0.001). Also four patients (12.12%) from group I and one patient (3.05%) from group II had nausea and vomiting in the postanaesthesia care unit and none of the patients had rescue analgesics. There were no differences between groups regarding nausea and vomiting, sedation and bleeding in the postoperative ward. CONCLUSIONIn adenotonsillectomy cases, peritonsillar infiltration of tramadol maintains efficient pain relief with lower incidence of nausea and vomiting.</description><identifier>ISSN: 0265-0215</identifier><identifier>EISSN: 1365-2346</identifier><identifier>DOI: 10.1097/EJA.0b013e32831c8988</identifier><identifier>PMID: 19401664</identifier><language>eng</language><publisher>England: European Society of Anaesthesiology</publisher><subject>Adenoidectomy ; Analgesics, Opioid - administration &amp; dosage ; Anesthesia Recovery Period ; Anesthesia, Local - methods ; Child ; Child, Preschool ; Double-Blind Method ; Female ; Humans ; Injections, Intravenous ; Male ; Pain Measurement ; Pain, Postoperative - drug therapy ; Postoperative Nausea and Vomiting - prevention &amp; control ; Prospective Studies ; Tonsillectomy ; Tramadol - administration &amp; dosage ; Treatment Outcome</subject><ispartof>European journal of anaesthesiology, 2009-04, Vol.26 (4), p.333-337</ispartof><rights>2009 European Society of Anaesthesiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4008-c341809bf6704724a6e2df936ec508d9ca2b402978009912f8f6b6667d46ddcf3</citedby><cites>FETCH-LOGICAL-c4008-c341809bf6704724a6e2df936ec508d9ca2b402978009912f8f6b6667d46ddcf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19401664$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akkaya, Taylan</creatorcontrib><creatorcontrib>Bedirli, Nurdan</creatorcontrib><creatorcontrib>Ceylan, Tijen</creatorcontrib><creatorcontrib>Matkap, Erkan</creatorcontrib><creatorcontrib>Gulen, Guven</creatorcontrib><creatorcontrib>Elverici, Ozan</creatorcontrib><creatorcontrib>Gumus, Haluk</creatorcontrib><creatorcontrib>Akin, Istemihan</creatorcontrib><title>Comparison of intravenous and peritonsillar infiltration of tramadol for postoperative pain relief in children following adenotonsillectomy</title><title>European journal of anaesthesiology</title><addtitle>Eur J Anaesthesiol</addtitle><description>BACKGROUND AND OBJECTIVEThe aim of this study was to compare the postoperative analgesic efficacy and side-effects of intravenous tramadol with peritonsillar infiltration of tramadol in children undergoing adenotonsillectomy. METHODSSixty-six children were randomized into two groupsgroup I received 2 mg kg tramadol intravenously and group II received 2 mg kg tramadol in 2 ml of normal saline (1 ml per tonsil) via peritonsillar infiltration. Modified Hannallah pain scale, nausea, vomiting, bleeding, rescue analgesia, sedation and Aldrete scores were recorded at the 1st, 15th, 30th and 60th minute postoperatively. The Aldrete score was used to determine the postanaesthesia care unit discharge criteria. Patients were evaluated for the analgesic requirement, nausea and vomiting, bleeding and sedation. RESULTSThere were no differences between groups during the first 1 h. In the postanaesthesia care unit, groups I and II had comparable pain scores that were not statistically significant (P &gt; 0.05). But during the first 24 h the additional analgesic requirement of group I (141.81 mg) was more than group II (83.63 mg) (P = 0.002). Pain scores in the postoperative ward at 6, 12 and 24 h were significantly higher in group I than in group II (P &lt; 0.001). Also four patients (12.12%) from group I and one patient (3.05%) from group II had nausea and vomiting in the postanaesthesia care unit and none of the patients had rescue analgesics. There were no differences between groups regarding nausea and vomiting, sedation and bleeding in the postoperative ward. CONCLUSIONIn adenotonsillectomy cases, peritonsillar infiltration of tramadol maintains efficient pain relief with lower incidence of nausea and vomiting.</description><subject>Adenoidectomy</subject><subject>Analgesics, Opioid - administration &amp; dosage</subject><subject>Anesthesia Recovery Period</subject><subject>Anesthesia, Local - methods</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Injections, Intravenous</subject><subject>Male</subject><subject>Pain Measurement</subject><subject>Pain, Postoperative - drug therapy</subject><subject>Postoperative Nausea and Vomiting - prevention &amp; control</subject><subject>Prospective Studies</subject><subject>Tonsillectomy</subject><subject>Tramadol - administration &amp; dosage</subject><subject>Treatment Outcome</subject><issn>0265-0215</issn><issn>1365-2346</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFuEzEQhi0EoqHtGyDkE7eUsdfx2scqKi1VJS5wXnntMTF47cXeNOoz8NK4SiQkDj15pPnms2Z-Qt4zuGKg-08399dXMALrsOOqY1ZppV6RFevkZs07IV-TFfBWA2ebM_Ku1p8AsGHA3pIzpgUwKcWK_NnmaTYl1Jxo9jSkpZhHTHlfqUmOzljCklMNMZrSuj7EBizhSLdyMi5H6nOhc65LbnzrPiKdTUi0YAz4LKV2F6IrmBoZYz6E9IMa1745udEueXq6IG-8iRUvT-85-f755tv2bv3w9fbL9vphbQWAWttOMAV69LIH0XNhJHLndSfRbkA5bQ0fBXDdKwCtGffKy1FK2TshnbO-Oycfj9655N97rMswhWqxrZiwLT7InvWS9aKB4gjakmst6Ie5hMmUp4HB8BzC0EIY_g-hjX04-ffjhO7f0OnqDVBH4JDjgqX-ivsDlmGHJi67l91_Afr9mT8</recordid><startdate>200904</startdate><enddate>200904</enddate><creator>Akkaya, Taylan</creator><creator>Bedirli, Nurdan</creator><creator>Ceylan, Tijen</creator><creator>Matkap, Erkan</creator><creator>Gulen, Guven</creator><creator>Elverici, Ozan</creator><creator>Gumus, Haluk</creator><creator>Akin, Istemihan</creator><general>European Society of Anaesthesiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200904</creationdate><title>Comparison of intravenous and peritonsillar infiltration of tramadol for postoperative pain relief in children following adenotonsillectomy</title><author>Akkaya, Taylan ; 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dosage</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akkaya, Taylan</creatorcontrib><creatorcontrib>Bedirli, Nurdan</creatorcontrib><creatorcontrib>Ceylan, Tijen</creatorcontrib><creatorcontrib>Matkap, Erkan</creatorcontrib><creatorcontrib>Gulen, Guven</creatorcontrib><creatorcontrib>Elverici, Ozan</creatorcontrib><creatorcontrib>Gumus, Haluk</creatorcontrib><creatorcontrib>Akin, Istemihan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of anaesthesiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akkaya, Taylan</au><au>Bedirli, Nurdan</au><au>Ceylan, Tijen</au><au>Matkap, Erkan</au><au>Gulen, Guven</au><au>Elverici, Ozan</au><au>Gumus, Haluk</au><au>Akin, Istemihan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of intravenous and peritonsillar infiltration of tramadol for postoperative pain relief in children following adenotonsillectomy</atitle><jtitle>European journal of anaesthesiology</jtitle><addtitle>Eur J Anaesthesiol</addtitle><date>2009-04</date><risdate>2009</risdate><volume>26</volume><issue>4</issue><spage>333</spage><epage>337</epage><pages>333-337</pages><issn>0265-0215</issn><eissn>1365-2346</eissn><abstract>BACKGROUND AND OBJECTIVEThe aim of this study was to compare the postoperative analgesic efficacy and side-effects of intravenous tramadol with peritonsillar infiltration of tramadol in children undergoing adenotonsillectomy. METHODSSixty-six children were randomized into two groupsgroup I received 2 mg kg tramadol intravenously and group II received 2 mg kg tramadol in 2 ml of normal saline (1 ml per tonsil) via peritonsillar infiltration. Modified Hannallah pain scale, nausea, vomiting, bleeding, rescue analgesia, sedation and Aldrete scores were recorded at the 1st, 15th, 30th and 60th minute postoperatively. The Aldrete score was used to determine the postanaesthesia care unit discharge criteria. Patients were evaluated for the analgesic requirement, nausea and vomiting, bleeding and sedation. RESULTSThere were no differences between groups during the first 1 h. In the postanaesthesia care unit, groups I and II had comparable pain scores that were not statistically significant (P &gt; 0.05). But during the first 24 h the additional analgesic requirement of group I (141.81 mg) was more than group II (83.63 mg) (P = 0.002). Pain scores in the postoperative ward at 6, 12 and 24 h were significantly higher in group I than in group II (P &lt; 0.001). Also four patients (12.12%) from group I and one patient (3.05%) from group II had nausea and vomiting in the postanaesthesia care unit and none of the patients had rescue analgesics. There were no differences between groups regarding nausea and vomiting, sedation and bleeding in the postoperative ward. CONCLUSIONIn adenotonsillectomy cases, peritonsillar infiltration of tramadol maintains efficient pain relief with lower incidence of nausea and vomiting.</abstract><cop>England</cop><pub>European Society of Anaesthesiology</pub><pmid>19401664</pmid><doi>10.1097/EJA.0b013e32831c8988</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
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subjects Adenoidectomy
Analgesics, Opioid - administration & dosage
Anesthesia Recovery Period
Anesthesia, Local - methods
Child
Child, Preschool
Double-Blind Method
Female
Humans
Injections, Intravenous
Male
Pain Measurement
Pain, Postoperative - drug therapy
Postoperative Nausea and Vomiting - prevention & control
Prospective Studies
Tonsillectomy
Tramadol - administration & dosage
Treatment Outcome
title Comparison of intravenous and peritonsillar infiltration of tramadol for postoperative pain relief in children following adenotonsillectomy
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