Impaired transient receptor potential vanilloid 1 in streptozotocin-induced diabetic hearts

Abstract Little is known about the effect of diabetes mellitus (DM) on transient receptor potential vanilloid 1 (TRPV1) located in cardiac sensory nerves. This study was performed to test the changes of TRPV1 and its main neuropeptides in diabetic hearts. DM was induced by intraperitoneal injection...

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Veröffentlicht in:	International journal of cardiology 2009-05, Vol.134 (2), p.290-292
Hauptverfasser:	Song, Jun-Xian, Wang, Li-Hong, Yao, Lei, Xu, Chao, Wei, Zhong-Hai, Zheng, Liang-Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcitonin gene-related peptide Cardiology. Vascular system Cardiovascular Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - physiopathology Diabetes. Impaired glucose tolerance Diabetic Neuropathies - metabolism Diabetic Neuropathies - physiopathology Diabetic neuropathy Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Heart Diseases - metabolism Heart Diseases - physiopathology Medical sciences Mice Mice, Inbred C57BL Substance P Transient receptor potential vanilloid 1 TRPV Cation Channels - genetics TRPV Cation Channels - metabolism
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Zusammenfassung:	Abstract Little is known about the effect of diabetes mellitus (DM) on transient receptor potential vanilloid 1 (TRPV1) located in cardiac sensory nerves. This study was performed to test the changes of TRPV1 and its main neuropeptides in diabetic hearts. DM was induced by intraperitoneal injection of streptozotocin (STZ) in C57BL/6J mice. The protein and mRNA expression of TRPV1, calcitonin gene-related peptide (CGRP) and substance P (SP) levels in hearts were measured, respectively. Compared with control mice, blood glucose was significantly increased in diabetic mice ( P < 0.05), while the protein and mRNA expression of TRPV1, CGRP and SP levels in hearts were essentially reduced in diabetic mice ( P < 0.05). TRPV1 and its main neuropeptides, CGRP and SP, in hearts were impaired during DM.
ISSN:	0167-5273 1874-1754
DOI:	10.1016/j.ijcard.2007.12.081