Interleukin-1 genetic polymorphism: association with gastric cancer in the high-risk Central-Western population of Venezuela
Genetic predisposition may play a role in the prevalence of gastric cancer (GC). To investigate the relationship between selected interleukin-1 (IL-1) loci polymorphisms and gastric cancer risk in the Central-Western region of Venezuela, where gastric cancer represents the first cause of cancer-rela...
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| Veröffentlicht in: | Revista medíca de Chile 2009-01, Vol.137 (1), p.63-70 |
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| creator | Cañas, Miryan Morán, Yeinmy Rivero, María Belén Bohórquez, Adolfo Villegas, Venus Rendón, Yanet Ramírez, Eddy Valderrama, Elvis Briceño, Zuly Chiurillo, Miguel Angel |
| description | Genetic predisposition may play a role in the prevalence of gastric cancer (GC).
To investigate the relationship between selected interleukin-1 (IL-1) loci polymorphisms and gastric cancer risk in the Central-Western region of Venezuela, where gastric cancer represents the first cause of cancer-related deaths.
In a case-control study we compared the frequencies of IL-1B-511 and IL-1B+3954 biallelic polymorphism, and the pentallelic VNTR of IL-IRN in 84 gastric adenocarcinoma paraffin-embedded biopsies and 84 endoscopic biopsies from cancer-free controls.
No significant increase in genotypic frequencies in gastric cancer was observed for any of the IL-1B-511 allelic combinations. However, in a logistic regression analysis, a significant association emerged for the IL-1B+3954C carrier genotype (odds ratio (OR): 6.2; 95% confidence intervals (CI) 1.3-28.8). On the other hand, a significantly higher risk was evidenced for the IL-IRN*2/*2 genotype (OR: 7.0; 95% CI2.3-21.5). Only patients with a well/moderately-differentiated adenocarcinoma that were homozygotes for the E-IRN*2/*2 genotype, had a higher risk than the complete gastric cancer group (OR: 8.1, 95% CI 2.5-26.8). Some genotype combinations among IL-1B-511, IL-1B+3954 and IL-IRN showed an increased risk for developing gastric cancer and well/moderate differentiated adenocarcinoma, that was dependent of the presence of IL-IRN*2/*2 genotype.
IL-IRN*2/*2 genotype is associated with increased risk of gastric cancer in the Venezuelan population. |
| format | Article |
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To investigate the relationship between selected interleukin-1 (IL-1) loci polymorphisms and gastric cancer risk in the Central-Western region of Venezuela, where gastric cancer represents the first cause of cancer-related deaths.
In a case-control study we compared the frequencies of IL-1B-511 and IL-1B+3954 biallelic polymorphism, and the pentallelic VNTR of IL-IRN in 84 gastric adenocarcinoma paraffin-embedded biopsies and 84 endoscopic biopsies from cancer-free controls.
No significant increase in genotypic frequencies in gastric cancer was observed for any of the IL-1B-511 allelic combinations. However, in a logistic regression analysis, a significant association emerged for the IL-1B+3954C carrier genotype (odds ratio (OR): 6.2; 95% confidence intervals (CI) 1.3-28.8). On the other hand, a significantly higher risk was evidenced for the IL-IRN*2/*2 genotype (OR: 7.0; 95% CI2.3-21.5). Only patients with a well/moderately-differentiated adenocarcinoma that were homozygotes for the E-IRN*2/*2 genotype, had a higher risk than the complete gastric cancer group (OR: 8.1, 95% CI 2.5-26.8). Some genotype combinations among IL-1B-511, IL-1B+3954 and IL-IRN showed an increased risk for developing gastric cancer and well/moderate differentiated adenocarcinoma, that was dependent of the presence of IL-IRN*2/*2 genotype.
IL-IRN*2/*2 genotype is associated with increased risk of gastric cancer in the Venezuelan population.</description><identifier>ISSN: 0034-9887</identifier><identifier>PMID: 19399323</identifier><language>spa</language><publisher>Chile</publisher><subject>Adenocarcinoma - genetics ; Adenocarcinoma - pathology ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Humans ; Interleukin-1 - genetics ; Male ; Middle Aged ; Odds Ratio ; Polymorphism, Genetic ; Risk Factors ; Stomach Neoplasms - genetics ; Stomach Neoplasms - pathology ; Venezuela ; Young Adult</subject><ispartof>Revista medíca de Chile, 2009-01, Vol.137 (1), p.63-70</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19399323$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cañas, Miryan</creatorcontrib><creatorcontrib>Morán, Yeinmy</creatorcontrib><creatorcontrib>Rivero, María Belén</creatorcontrib><creatorcontrib>Bohórquez, Adolfo</creatorcontrib><creatorcontrib>Villegas, Venus</creatorcontrib><creatorcontrib>Rendón, Yanet</creatorcontrib><creatorcontrib>Ramírez, Eddy</creatorcontrib><creatorcontrib>Valderrama, Elvis</creatorcontrib><creatorcontrib>Briceño, Zuly</creatorcontrib><creatorcontrib>Chiurillo, Miguel Angel</creatorcontrib><title>Interleukin-1 genetic polymorphism: association with gastric cancer in the high-risk Central-Western population of Venezuela</title><title>Revista medíca de Chile</title><addtitle>Rev Med Chil</addtitle><description>Genetic predisposition may play a role in the prevalence of gastric cancer (GC).
To investigate the relationship between selected interleukin-1 (IL-1) loci polymorphisms and gastric cancer risk in the Central-Western region of Venezuela, where gastric cancer represents the first cause of cancer-related deaths.
In a case-control study we compared the frequencies of IL-1B-511 and IL-1B+3954 biallelic polymorphism, and the pentallelic VNTR of IL-IRN in 84 gastric adenocarcinoma paraffin-embedded biopsies and 84 endoscopic biopsies from cancer-free controls.
No significant increase in genotypic frequencies in gastric cancer was observed for any of the IL-1B-511 allelic combinations. However, in a logistic regression analysis, a significant association emerged for the IL-1B+3954C carrier genotype (odds ratio (OR): 6.2; 95% confidence intervals (CI) 1.3-28.8). On the other hand, a significantly higher risk was evidenced for the IL-IRN*2/*2 genotype (OR: 7.0; 95% CI2.3-21.5). Only patients with a well/moderately-differentiated adenocarcinoma that were homozygotes for the E-IRN*2/*2 genotype, had a higher risk than the complete gastric cancer group (OR: 8.1, 95% CI 2.5-26.8). Some genotype combinations among IL-1B-511, IL-1B+3954 and IL-IRN showed an increased risk for developing gastric cancer and well/moderate differentiated adenocarcinoma, that was dependent of the presence of IL-IRN*2/*2 genotype.
IL-IRN*2/*2 genotype is associated with increased risk of gastric cancer in the Venezuelan population.</description><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - pathology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Interleukin-1 - genetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Polymorphism, Genetic</subject><subject>Risk Factors</subject><subject>Stomach Neoplasms - genetics</subject><subject>Stomach Neoplasms - pathology</subject><subject>Venezuela</subject><subject>Young Adult</subject><issn>0034-9887</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRbMA0VL4BeQVO0t-NLHNDlU8KlViw2MZTZNJY-o4wXaEQHw8kVrWrGYWZ869mpNszphcUqO1mmXnMb4zJlTB9Vk240YaI4WcZz9rnzA4HPfWU0526DHZigy9--r6MLQ2djcEYuwrC8n2nnza1JIdxBQmrAJfYSDWk9Qiae2upcHGPVmhTwEcfcM42f2kG0Z3uO8b8jqFfI_o4CI7bcBFvDzORfZyf_e8eqSbp4f16nZDB65YonqLkutaNqrRAIZPey4ZQKURC80qDlhgXjQi39YgFdZCScXrumBmKTXncpFdH7xD6D_GqVPZ2Vihc-CxH2NZKK6WudD_goLlnBshJvDqCI7bDutyCLaD8FX-PVb-At6Cdhk</recordid><startdate>200901</startdate><enddate>200901</enddate><creator>Cañas, Miryan</creator><creator>Morán, Yeinmy</creator><creator>Rivero, María Belén</creator><creator>Bohórquez, Adolfo</creator><creator>Villegas, Venus</creator><creator>Rendón, Yanet</creator><creator>Ramírez, Eddy</creator><creator>Valderrama, Elvis</creator><creator>Briceño, Zuly</creator><creator>Chiurillo, Miguel Angel</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200901</creationdate><title>Interleukin-1 genetic polymorphism: association with gastric cancer in the high-risk Central-Western population of Venezuela</title><author>Cañas, Miryan ; Morán, Yeinmy ; Rivero, María Belén ; Bohórquez, Adolfo ; Villegas, Venus ; Rendón, Yanet ; Ramírez, Eddy ; Valderrama, Elvis ; Briceño, Zuly ; Chiurillo, Miguel Angel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p170t-8be318d3f7f8aa9118d530aac8ee680c1ae6e56f25bda37ed27371dd609438113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>spa</language><creationdate>2009</creationdate><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - pathology</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Interleukin-1 - genetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Polymorphism, Genetic</topic><topic>Risk Factors</topic><topic>Stomach Neoplasms - genetics</topic><topic>Stomach Neoplasms - pathology</topic><topic>Venezuela</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cañas, Miryan</creatorcontrib><creatorcontrib>Morán, Yeinmy</creatorcontrib><creatorcontrib>Rivero, María Belén</creatorcontrib><creatorcontrib>Bohórquez, Adolfo</creatorcontrib><creatorcontrib>Villegas, Venus</creatorcontrib><creatorcontrib>Rendón, Yanet</creatorcontrib><creatorcontrib>Ramírez, Eddy</creatorcontrib><creatorcontrib>Valderrama, Elvis</creatorcontrib><creatorcontrib>Briceño, Zuly</creatorcontrib><creatorcontrib>Chiurillo, Miguel Angel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Revista medíca de Chile</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cañas, Miryan</au><au>Morán, Yeinmy</au><au>Rivero, María Belén</au><au>Bohórquez, Adolfo</au><au>Villegas, Venus</au><au>Rendón, Yanet</au><au>Ramírez, Eddy</au><au>Valderrama, Elvis</au><au>Briceño, Zuly</au><au>Chiurillo, Miguel Angel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-1 genetic polymorphism: association with gastric cancer in the high-risk Central-Western population of Venezuela</atitle><jtitle>Revista medíca de Chile</jtitle><addtitle>Rev Med Chil</addtitle><date>2009-01</date><risdate>2009</risdate><volume>137</volume><issue>1</issue><spage>63</spage><epage>70</epage><pages>63-70</pages><issn>0034-9887</issn><abstract>Genetic predisposition may play a role in the prevalence of gastric cancer (GC).
To investigate the relationship between selected interleukin-1 (IL-1) loci polymorphisms and gastric cancer risk in the Central-Western region of Venezuela, where gastric cancer represents the first cause of cancer-related deaths.
In a case-control study we compared the frequencies of IL-1B-511 and IL-1B+3954 biallelic polymorphism, and the pentallelic VNTR of IL-IRN in 84 gastric adenocarcinoma paraffin-embedded biopsies and 84 endoscopic biopsies from cancer-free controls.
No significant increase in genotypic frequencies in gastric cancer was observed for any of the IL-1B-511 allelic combinations. However, in a logistic regression analysis, a significant association emerged for the IL-1B+3954C carrier genotype (odds ratio (OR): 6.2; 95% confidence intervals (CI) 1.3-28.8). On the other hand, a significantly higher risk was evidenced for the IL-IRN*2/*2 genotype (OR: 7.0; 95% CI2.3-21.5). Only patients with a well/moderately-differentiated adenocarcinoma that were homozygotes for the E-IRN*2/*2 genotype, had a higher risk than the complete gastric cancer group (OR: 8.1, 95% CI 2.5-26.8). Some genotype combinations among IL-1B-511, IL-1B+3954 and IL-IRN showed an increased risk for developing gastric cancer and well/moderate differentiated adenocarcinoma, that was dependent of the presence of IL-IRN*2/*2 genotype.
IL-IRN*2/*2 genotype is associated with increased risk of gastric cancer in the Venezuelan population.</abstract><cop>Chile</cop><pmid>19399323</pmid><tpages>8</tpages></addata></record> |
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| subjects | Adenocarcinoma - genetics Adenocarcinoma - pathology Adolescent Adult Aged Aged, 80 and over Case-Control Studies Female Gene Frequency Genetic Predisposition to Disease Humans Interleukin-1 - genetics Male Middle Aged Odds Ratio Polymorphism, Genetic Risk Factors Stomach Neoplasms - genetics Stomach Neoplasms - pathology Venezuela Young Adult |
| title | Interleukin-1 genetic polymorphism: association with gastric cancer in the high-risk Central-Western population of Venezuela |
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