Neuropsychological performance in early and late onset Alzheimer's disease: comparisons in a memory clinic population
Objectives To compare the neuropsychological performance associated with early and late onset Alzheimer's disease (AD), in order to identify differences and compare these with previous reports. Methods Patients attending a memory clinic were given a detailed multi‐disciplinary diagnostic assess...
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| Veröffentlicht in: | International journal of geriatric psychiatry 2004-12, Vol.19 (12), p.1140-1147 |
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| container_title | International journal of geriatric psychiatry |
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| creator | Suribhatla, Srinivas Baillon, Sarah Dennis, Michael Marudkar, Mangesh Muhammad, Saquib Munro, Dena Spreadbury, Christine Lindesay, James |
| description | Objectives
To compare the neuropsychological performance associated with early and late onset Alzheimer's disease (AD), in order to identify differences and compare these with previous reports.
Methods
Patients attending a memory clinic were given a detailed multi‐disciplinary diagnostic assessment, including a battery of neuropsychological tests. From those meeting ICD‐10 criteria for Alzheimer's disease (AD), an early‐onset (EO) group (n = 40) and a late‐onset (LO) group (n = 90) were identified, and their performances compared. Patients with mixed dementia and co‐morbid depression were excluded.
Results
After adjustment, the EO and LO groups performed at a comparable level on the majority of the neuropsychological tests. The LO group performed better on the WAIS digit span test, AMIPB Complex Design and the written picture description, and the EO group performed better on the WAIS similarities test and the Boston naming test.
Conclusions
These findings suggest that, after adjusting for overall dementia severity and pre‐morbid IQ, there is greater fronto‐parietal/right hemisphere involvement in early‐onset AD, and greater temporal/left hemisphere involvement in late‐onset AD. This may be due to different genetic risk profiles for AD at different ages. Copyright © 2004 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/gps.1196 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67172562</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>21144434</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4456-36a86dca15728fdadb614bcc72d2ad63487ae31497fc13a3b57abb5896e5936c3</originalsourceid><addsrcrecordid>eNqF0VuL1DAYBuAgijuugr9AguDhpmvObb1bBh0Pwyq4Hu5Cmn7dzW7a1GSK1l9vhikuCOJVLvLk_cj3IvSQkhNKCHtxMaYTSmt1C60oqeuCUqVuoxWpKlkoxskRupfSFSH5jlZ30RGVkilOqhWazmCKYUyzvQw-XDhrPB4hdiH2ZrCA3YDBRD9jM7TYmx3gMCTY4VP_6xJcD_FZwq1LYBK8xDb0o4kuZbJ_aHAPfYgztt4NzuIxjFOOcGG4j-50xid4sJzH6PPrV-frN8X2w-bt-nRbWCGkKrgylWqtobJkVdeatlFUNNaWrGWmVVxUpQFORV12lnLDG1mappFVrUDWXFl-jJ4ecscYvk-Qdrp3yYL3ZoAwJa1KWjKZN_Q_yCgVQnCR4eO_4FWY4pA_oRkjUlSU84yeH5CNIaUInR6j602cNSV6X5jOhel9YZk-WvKmpof2Bi4NZfBkASblcrqYa3HpxinOSkL3rji4H87D_M-BevPx0zJ48S7t4Ocfb-J13govpf56ttHr9-X2_Nu7L5ry36_0vFM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>220548133</pqid></control><display><type>article</type><title>Neuropsychological performance in early and late onset Alzheimer's disease: comparisons in a memory clinic population</title><source>Wiley-Blackwell Journals</source><source>MEDLINE</source><creator>Suribhatla, Srinivas ; Baillon, Sarah ; Dennis, Michael ; Marudkar, Mangesh ; Muhammad, Saquib ; Munro, Dena ; Spreadbury, Christine ; Lindesay, James</creator><creatorcontrib>Suribhatla, Srinivas ; Baillon, Sarah ; Dennis, Michael ; Marudkar, Mangesh ; Muhammad, Saquib ; Munro, Dena ; Spreadbury, Christine ; Lindesay, James</creatorcontrib><description>Objectives
To compare the neuropsychological performance associated with early and late onset Alzheimer's disease (AD), in order to identify differences and compare these with previous reports.
Methods
Patients attending a memory clinic were given a detailed multi‐disciplinary diagnostic assessment, including a battery of neuropsychological tests. From those meeting ICD‐10 criteria for Alzheimer's disease (AD), an early‐onset (EO) group (n = 40) and a late‐onset (LO) group (n = 90) were identified, and their performances compared. Patients with mixed dementia and co‐morbid depression were excluded.
Results
After adjustment, the EO and LO groups performed at a comparable level on the majority of the neuropsychological tests. The LO group performed better on the WAIS digit span test, AMIPB Complex Design and the written picture description, and the EO group performed better on the WAIS similarities test and the Boston naming test.
Conclusions
These findings suggest that, after adjusting for overall dementia severity and pre‐morbid IQ, there is greater fronto‐parietal/right hemisphere involvement in early‐onset AD, and greater temporal/left hemisphere involvement in late‐onset AD. This may be due to different genetic risk profiles for AD at different ages. Copyright © 2004 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0885-6230</identifier><identifier>EISSN: 1099-1166</identifier><identifier>DOI: 10.1002/gps.1196</identifier><identifier>PMID: 15526308</identifier><identifier>CODEN: IJGPES</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Age of Onset ; Aged ; Alzheimer Disease - psychology ; Alzheimer's disease ; Biological and medical sciences ; Brain ; Cognition ; Cognition & reasoning ; Comparative analysis ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; early onset ; Female ; Fundamental and applied biological sciences. Psychology ; Geriatric psychiatry ; Geriatrics ; Humans ; Intelligence Tests ; Language Tests ; late onset ; Male ; Medical sciences ; Memory ; Middle Aged ; Neurology ; Neuropsychological Tests ; neuropsychology ; Psychoanalysis ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Speech</subject><ispartof>International journal of geriatric psychiatry, 2004-12, Vol.19 (12), p.1140-1147</ispartof><rights>Copyright © 2004 John Wiley & Sons, Ltd.</rights><rights>2005 INIST-CNRS</rights><rights>Copyright (c) 2004 John Wiley & Sons, Ltd.</rights><rights>Copyright John Wiley and Sons, Limited Dec 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4456-36a86dca15728fdadb614bcc72d2ad63487ae31497fc13a3b57abb5896e5936c3</citedby><cites>FETCH-LOGICAL-c4456-36a86dca15728fdadb614bcc72d2ad63487ae31497fc13a3b57abb5896e5936c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fgps.1196$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fgps.1196$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16327018$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15526308$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suribhatla, Srinivas</creatorcontrib><creatorcontrib>Baillon, Sarah</creatorcontrib><creatorcontrib>Dennis, Michael</creatorcontrib><creatorcontrib>Marudkar, Mangesh</creatorcontrib><creatorcontrib>Muhammad, Saquib</creatorcontrib><creatorcontrib>Munro, Dena</creatorcontrib><creatorcontrib>Spreadbury, Christine</creatorcontrib><creatorcontrib>Lindesay, James</creatorcontrib><title>Neuropsychological performance in early and late onset Alzheimer's disease: comparisons in a memory clinic population</title><title>International journal of geriatric psychiatry</title><addtitle>Int. J. Geriat. Psychiatry</addtitle><description>Objectives
To compare the neuropsychological performance associated with early and late onset Alzheimer's disease (AD), in order to identify differences and compare these with previous reports.
Methods
Patients attending a memory clinic were given a detailed multi‐disciplinary diagnostic assessment, including a battery of neuropsychological tests. From those meeting ICD‐10 criteria for Alzheimer's disease (AD), an early‐onset (EO) group (n = 40) and a late‐onset (LO) group (n = 90) were identified, and their performances compared. Patients with mixed dementia and co‐morbid depression were excluded.
Results
After adjustment, the EO and LO groups performed at a comparable level on the majority of the neuropsychological tests. The LO group performed better on the WAIS digit span test, AMIPB Complex Design and the written picture description, and the EO group performed better on the WAIS similarities test and the Boston naming test.
Conclusions
These findings suggest that, after adjusting for overall dementia severity and pre‐morbid IQ, there is greater fronto‐parietal/right hemisphere involvement in early‐onset AD, and greater temporal/left hemisphere involvement in late‐onset AD. This may be due to different genetic risk profiles for AD at different ages. Copyright © 2004 John Wiley & Sons, Ltd.</description><subject>Age of Onset</subject><subject>Aged</subject><subject>Alzheimer Disease - psychology</subject><subject>Alzheimer's disease</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Cognition</subject><subject>Cognition & reasoning</subject><subject>Comparative analysis</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>early onset</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Geriatric psychiatry</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Intelligence Tests</subject><subject>Language Tests</subject><subject>late onset</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>neuropsychology</subject><subject>Psychoanalysis</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Speech</subject><issn>0885-6230</issn><issn>1099-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0VuL1DAYBuAgijuugr9AguDhpmvObb1bBh0Pwyq4Hu5Cmn7dzW7a1GSK1l9vhikuCOJVLvLk_cj3IvSQkhNKCHtxMaYTSmt1C60oqeuCUqVuoxWpKlkoxskRupfSFSH5jlZ30RGVkilOqhWazmCKYUyzvQw-XDhrPB4hdiH2ZrCA3YDBRD9jM7TYmx3gMCTY4VP_6xJcD_FZwq1LYBK8xDb0o4kuZbJ_aHAPfYgztt4NzuIxjFOOcGG4j-50xid4sJzH6PPrV-frN8X2w-bt-nRbWCGkKrgylWqtobJkVdeatlFUNNaWrGWmVVxUpQFORV12lnLDG1mappFVrUDWXFl-jJ4ecscYvk-Qdrp3yYL3ZoAwJa1KWjKZN_Q_yCgVQnCR4eO_4FWY4pA_oRkjUlSU84yeH5CNIaUInR6j602cNSV6X5jOhel9YZk-WvKmpof2Bi4NZfBkASblcrqYa3HpxinOSkL3rji4H87D_M-BevPx0zJ48S7t4Ocfb-J13govpf56ttHr9-X2_Nu7L5ry36_0vFM</recordid><startdate>200412</startdate><enddate>200412</enddate><creator>Suribhatla, Srinivas</creator><creator>Baillon, Sarah</creator><creator>Dennis, Michael</creator><creator>Marudkar, Mangesh</creator><creator>Muhammad, Saquib</creator><creator>Munro, Dena</creator><creator>Spreadbury, Christine</creator><creator>Lindesay, James</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>200412</creationdate><title>Neuropsychological performance in early and late onset Alzheimer's disease: comparisons in a memory clinic population</title><author>Suribhatla, Srinivas ; Baillon, Sarah ; Dennis, Michael ; Marudkar, Mangesh ; Muhammad, Saquib ; Munro, Dena ; Spreadbury, Christine ; Lindesay, James</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4456-36a86dca15728fdadb614bcc72d2ad63487ae31497fc13a3b57abb5896e5936c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Age of Onset</topic><topic>Aged</topic><topic>Alzheimer Disease - psychology</topic><topic>Alzheimer's disease</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Cognition</topic><topic>Cognition & reasoning</topic><topic>Comparative analysis</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>early onset</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Geriatric psychiatry</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>Intelligence Tests</topic><topic>Language Tests</topic><topic>late onset</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>neuropsychology</topic><topic>Psychoanalysis</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Speech</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suribhatla, Srinivas</creatorcontrib><creatorcontrib>Baillon, Sarah</creatorcontrib><creatorcontrib>Dennis, Michael</creatorcontrib><creatorcontrib>Marudkar, Mangesh</creatorcontrib><creatorcontrib>Muhammad, Saquib</creatorcontrib><creatorcontrib>Munro, Dena</creatorcontrib><creatorcontrib>Spreadbury, Christine</creatorcontrib><creatorcontrib>Lindesay, James</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of geriatric psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suribhatla, Srinivas</au><au>Baillon, Sarah</au><au>Dennis, Michael</au><au>Marudkar, Mangesh</au><au>Muhammad, Saquib</au><au>Munro, Dena</au><au>Spreadbury, Christine</au><au>Lindesay, James</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuropsychological performance in early and late onset Alzheimer's disease: comparisons in a memory clinic population</atitle><jtitle>International journal of geriatric psychiatry</jtitle><addtitle>Int. J. Geriat. Psychiatry</addtitle><date>2004-12</date><risdate>2004</risdate><volume>19</volume><issue>12</issue><spage>1140</spage><epage>1147</epage><pages>1140-1147</pages><issn>0885-6230</issn><eissn>1099-1166</eissn><coden>IJGPES</coden><abstract>Objectives
To compare the neuropsychological performance associated with early and late onset Alzheimer's disease (AD), in order to identify differences and compare these with previous reports.
Methods
Patients attending a memory clinic were given a detailed multi‐disciplinary diagnostic assessment, including a battery of neuropsychological tests. From those meeting ICD‐10 criteria for Alzheimer's disease (AD), an early‐onset (EO) group (n = 40) and a late‐onset (LO) group (n = 90) were identified, and their performances compared. Patients with mixed dementia and co‐morbid depression were excluded.
Results
After adjustment, the EO and LO groups performed at a comparable level on the majority of the neuropsychological tests. The LO group performed better on the WAIS digit span test, AMIPB Complex Design and the written picture description, and the EO group performed better on the WAIS similarities test and the Boston naming test.
Conclusions
These findings suggest that, after adjusting for overall dementia severity and pre‐morbid IQ, there is greater fronto‐parietal/right hemisphere involvement in early‐onset AD, and greater temporal/left hemisphere involvement in late‐onset AD. This may be due to different genetic risk profiles for AD at different ages. Copyright © 2004 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>15526308</pmid><doi>10.1002/gps.1196</doi><tpages>8</tpages></addata></record> |
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| ispartof | International journal of geriatric psychiatry, 2004-12, Vol.19 (12), p.1140-1147 |
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| subjects | Age of Onset Aged Alzheimer Disease - psychology Alzheimer's disease Biological and medical sciences Brain Cognition Cognition & reasoning Comparative analysis Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases early onset Female Fundamental and applied biological sciences. Psychology Geriatric psychiatry Geriatrics Humans Intelligence Tests Language Tests late onset Male Medical sciences Memory Middle Aged Neurology Neuropsychological Tests neuropsychology Psychoanalysis Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Speech |
| title | Neuropsychological performance in early and late onset Alzheimer's disease: comparisons in a memory clinic population |
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