Stabilization of proteins in dry powder formulations using supercritical fluid technology

Therapeutic proteins have become essential in the treatment of many diseases. Their formulation in dry form is often required to improve their stability. Traditional freeze-drying or spray-drying processes are often harmful to labile proteins and could be replaced by supercritical fluid (SCF) drying...

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Veröffentlicht in:	Pharmaceutical research 2004-11, Vol.21 (11), p.1955-1969
Hauptverfasser:	Jovanović, Natasa, Bouchard, Andréanne, Hofland, Gerard W, Witkamp, Geert-Jan, Crommelin, Daan J A, Jiskoot, Wim
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbon Dioxide Chemistry, Pharmaceutical - methods Desiccation Pharmaceutical sciences Physical properties Powders Proteins Proteins - administration & dosage Proteins - chemistry Solutions Solvents
Online-Zugang:	Volltext
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