Relationship between osteopenia and lumbar intervertebral disc degeneration in ovariectomized rats
Ovariectomy (OVX) can cause bone loss in rats, but little is known about how it also induces lumbar intervertebral disc degeneration (LVD). This study investigated how estrogen deficiency affected intervertebral discs in OVX rats. Thirty 3-month-old female Sprague-Dawley rats were divided randomly i...
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| Veröffentlicht in: | Calcified tissue international 2004-09, Vol.75 (3), p.205-213 |
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| description | Ovariectomy (OVX) can cause bone loss in rats, but little is known about how it also induces lumbar intervertebral disc degeneration (LVD). This study investigated how estrogen deficiency affected intervertebral discs in OVX rats. Thirty 3-month-old female Sprague-Dawley rats were divided randomly into three equal groups. The baseline control group (BL) was killed at the beginning of the experiment. An ovariectomy was performed in 10 rats (OVX group) and another group of 10 rats was subjected to a sham surgery (Sham group). The OVX rats were untreated after the surgery to allow for the development of moderate osteopenia. Bone mineral density (BMD) measurement and bone histomorphometric analysis were applied to the segments of lumbar spines in all rats killed 6 months after surgery. The pathological changes of intervertebral discs were observed and the degree of LVD was scored by a histological scoring system. The BMD of the spines (L3-L5) in the OVX group decreased significantly compared with the Sham group. The bone volume indices in the OVX group were significantly lower, but the bone turnover rate parameters were significantly higher than those in the Sham group (P < 0.01). The histological scores for LVD in the OVX group were significantly higher than those in the Sham group (P < 0.01). There was a significant negative correlation between the BMD and Grade II discs in the OVX rats (P = 0.042). In conclusion, LVD occurs in the OVX rats and the degeneration of cartilage end plates may be a pathogenic factor in disc degeneration. |
| doi_str_mv | 10.1007/s00223-004-0240-8 |
| format | Article |
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This study investigated how estrogen deficiency affected intervertebral discs in OVX rats. Thirty 3-month-old female Sprague-Dawley rats were divided randomly into three equal groups. The baseline control group (BL) was killed at the beginning of the experiment. An ovariectomy was performed in 10 rats (OVX group) and another group of 10 rats was subjected to a sham surgery (Sham group). The OVX rats were untreated after the surgery to allow for the development of moderate osteopenia. Bone mineral density (BMD) measurement and bone histomorphometric analysis were applied to the segments of lumbar spines in all rats killed 6 months after surgery. The pathological changes of intervertebral discs were observed and the degree of LVD was scored by a histological scoring system. The BMD of the spines (L3-L5) in the OVX group decreased significantly compared with the Sham group. The bone volume indices in the OVX group were significantly lower, but the bone turnover rate parameters were significantly higher than those in the Sham group (P < 0.01). The histological scores for LVD in the OVX group were significantly higher than those in the Sham group (P < 0.01). There was a significant negative correlation between the BMD and Grade II discs in the OVX rats (P = 0.042). In conclusion, LVD occurs in the OVX rats and the degeneration of cartilage end plates may be a pathogenic factor in disc degeneration.</description><identifier>ISSN: 0171-967X</identifier><identifier>EISSN: 1432-0827</identifier><identifier>DOI: 10.1007/s00223-004-0240-8</identifier><identifier>PMID: 15185057</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Animals ; Bone Density ; Bone Diseases, Metabolic - etiology ; Bone Diseases, Metabolic - physiopathology ; Disease Models, Animal ; Female ; Humans ; Intervertebral Disc - pathology ; Lumbar Vertebrae - pathology ; Osteoporosis, Postmenopausal - physiopathology ; Ovariectomy - adverse effects ; Rats ; Rats, Sprague-Dawley</subject><ispartof>Calcified tissue international, 2004-09, Vol.75 (3), p.205-213</ispartof><rights>Copyright Springer-Verlag 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-fc04605b4721680b1c03d58fe1779567aa0c0200d7df138e1557c611f87469883</citedby><cites>FETCH-LOGICAL-c355t-fc04605b4721680b1c03d58fe1779567aa0c0200d7df138e1557c611f87469883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15185057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, T</creatorcontrib><creatorcontrib>Zhang, L</creatorcontrib><creatorcontrib>Huang, C</creatorcontrib><creatorcontrib>Cheng, A G</creatorcontrib><creatorcontrib>Dang, G T</creatorcontrib><title>Relationship between osteopenia and lumbar intervertebral disc degeneration in ovariectomized rats</title><title>Calcified tissue international</title><addtitle>Calcif Tissue Int</addtitle><description>Ovariectomy (OVX) can cause bone loss in rats, but little is known about how it also induces lumbar intervertebral disc degeneration (LVD). This study investigated how estrogen deficiency affected intervertebral discs in OVX rats. Thirty 3-month-old female Sprague-Dawley rats were divided randomly into three equal groups. The baseline control group (BL) was killed at the beginning of the experiment. An ovariectomy was performed in 10 rats (OVX group) and another group of 10 rats was subjected to a sham surgery (Sham group). The OVX rats were untreated after the surgery to allow for the development of moderate osteopenia. Bone mineral density (BMD) measurement and bone histomorphometric analysis were applied to the segments of lumbar spines in all rats killed 6 months after surgery. The pathological changes of intervertebral discs were observed and the degree of LVD was scored by a histological scoring system. The BMD of the spines (L3-L5) in the OVX group decreased significantly compared with the Sham group. The bone volume indices in the OVX group were significantly lower, but the bone turnover rate parameters were significantly higher than those in the Sham group (P < 0.01). The histological scores for LVD in the OVX group were significantly higher than those in the Sham group (P < 0.01). There was a significant negative correlation between the BMD and Grade II discs in the OVX rats (P = 0.042). In conclusion, LVD occurs in the OVX rats and the degeneration of cartilage end plates may be a pathogenic factor in disc degeneration.</description><subject>Animals</subject><subject>Bone Density</subject><subject>Bone Diseases, Metabolic - etiology</subject><subject>Bone Diseases, Metabolic - physiopathology</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Humans</subject><subject>Intervertebral Disc - pathology</subject><subject>Lumbar Vertebrae - pathology</subject><subject>Osteoporosis, Postmenopausal - physiopathology</subject><subject>Ovariectomy - adverse effects</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>0171-967X</issn><issn>1432-0827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkc9L3UAQx5ei1NfX_gG9lMWDt9SZ_Z2jiFpBKBQLvS2bZKKRJPu6m1j0rzfP96DgxdMc5jPfmeHD2FeE7whgTzOAELIAUAUIBYX7wFaopCjACXvAVoAWi9LYP0fsU84PAKiMMR_ZEWp0GrRdseoX9WHq4pjvuw2vaPpHNPKYJ4obGrvAw9jwfh6qkHg3TpQeKU1UpdDzpss1b-iORkqvEQvA42NIHdVTHLpnavjSyJ_ZYRv6TF_2dc1-X17cnv8obn5eXZ-f3RS11Hoq2hqUAV0pK9A4qLAG2WjXElpbamNDgBoEQGObFqUj1NrWBrF1VpnSOblmJ7vcTYp_Z8qTH5YLqe_DSHHO3li0UCp8F0SrSilKvYDHb8CHOKdxecILFMtOlGqBcAfVKeacqPWb1A0hPXkEv9Xkd5r8oslvNfntqd_2wXM1UPN_Yu9FvgCTlo1l</recordid><startdate>200409</startdate><enddate>200409</enddate><creator>Wang, T</creator><creator>Zhang, L</creator><creator>Huang, C</creator><creator>Cheng, A G</creator><creator>Dang, G T</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200409</creationdate><title>Relationship between osteopenia and lumbar intervertebral disc degeneration in ovariectomized rats</title><author>Wang, T ; Zhang, L ; Huang, C ; Cheng, A G ; Dang, G T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c355t-fc04605b4721680b1c03d58fe1779567aa0c0200d7df138e1557c611f87469883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Bone Density</topic><topic>Bone Diseases, Metabolic - etiology</topic><topic>Bone Diseases, Metabolic - physiopathology</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Humans</topic><topic>Intervertebral Disc - pathology</topic><topic>Lumbar Vertebrae - pathology</topic><topic>Osteoporosis, Postmenopausal - physiopathology</topic><topic>Ovariectomy - adverse effects</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, T</creatorcontrib><creatorcontrib>Zhang, L</creatorcontrib><creatorcontrib>Huang, C</creatorcontrib><creatorcontrib>Cheng, A G</creatorcontrib><creatorcontrib>Dang, G T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Calcified tissue international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, T</au><au>Zhang, L</au><au>Huang, C</au><au>Cheng, A G</au><au>Dang, G T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between osteopenia and lumbar intervertebral disc degeneration in ovariectomized rats</atitle><jtitle>Calcified tissue international</jtitle><addtitle>Calcif Tissue Int</addtitle><date>2004-09</date><risdate>2004</risdate><volume>75</volume><issue>3</issue><spage>205</spage><epage>213</epage><pages>205-213</pages><issn>0171-967X</issn><eissn>1432-0827</eissn><abstract>Ovariectomy (OVX) can cause bone loss in rats, but little is known about how it also induces lumbar intervertebral disc degeneration (LVD). This study investigated how estrogen deficiency affected intervertebral discs in OVX rats. Thirty 3-month-old female Sprague-Dawley rats were divided randomly into three equal groups. The baseline control group (BL) was killed at the beginning of the experiment. An ovariectomy was performed in 10 rats (OVX group) and another group of 10 rats was subjected to a sham surgery (Sham group). The OVX rats were untreated after the surgery to allow for the development of moderate osteopenia. Bone mineral density (BMD) measurement and bone histomorphometric analysis were applied to the segments of lumbar spines in all rats killed 6 months after surgery. The pathological changes of intervertebral discs were observed and the degree of LVD was scored by a histological scoring system. The BMD of the spines (L3-L5) in the OVX group decreased significantly compared with the Sham group. The bone volume indices in the OVX group were significantly lower, but the bone turnover rate parameters were significantly higher than those in the Sham group (P < 0.01). The histological scores for LVD in the OVX group were significantly higher than those in the Sham group (P < 0.01). There was a significant negative correlation between the BMD and Grade II discs in the OVX rats (P = 0.042). In conclusion, LVD occurs in the OVX rats and the degeneration of cartilage end plates may be a pathogenic factor in disc degeneration.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>15185057</pmid><doi>10.1007/s00223-004-0240-8</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals Bone Density Bone Diseases, Metabolic - etiology Bone Diseases, Metabolic - physiopathology Disease Models, Animal Female Humans Intervertebral Disc - pathology Lumbar Vertebrae - pathology Osteoporosis, Postmenopausal - physiopathology Ovariectomy - adverse effects Rats Rats, Sprague-Dawley |
| title | Relationship between osteopenia and lumbar intervertebral disc degeneration in ovariectomized rats |
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