Diagnosis, biology and treatment of hairy-cell leukaemia
Hairy-cell leukaemia (HCL) is usually readily diagnosed by seeing typical hairy cells (HCs) in the blood film. The diagnosis is then confirmed by tartrate-resistant acid phosphatase staining, marker analysis, and bone marrow examination. HCs are clonal mature memory B cells with specific features of...
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| Veröffentlicht in: | Clinical and experimental medicine 2004-12, Vol.4 (3), p.132-138 |
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| creator | Allsup, D J Cawley, J C |
| description | Hairy-cell leukaemia (HCL) is usually readily diagnosed by seeing typical hairy cells (HCs) in the blood film. The diagnosis is then confirmed by tartrate-resistant acid phosphatase staining, marker analysis, and bone marrow examination. HCs are clonal mature memory B cells with specific features of activation. This HC activation is responsible for many of the pathological features of the disease, including its distinctive bone marrow fibrosis, splenic red pulp invasion, and pseudo-sinus formation. Chlorodeoxyadenasine is the treatment of first choice. Deoxycoformycin and rituximab are useful for the treatment of relapsed/refractory disease. The nature of the primary oncogenic event(s) remains unknown and is the major unresolved issue in HCL. |
| doi_str_mv | 10.1007/s10238-004-0046-z |
| format | Article |
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The diagnosis is then confirmed by tartrate-resistant acid phosphatase staining, marker analysis, and bone marrow examination. HCs are clonal mature memory B cells with specific features of activation. This HC activation is responsible for many of the pathological features of the disease, including its distinctive bone marrow fibrosis, splenic red pulp invasion, and pseudo-sinus formation. Chlorodeoxyadenasine is the treatment of first choice. Deoxycoformycin and rituximab are useful for the treatment of relapsed/refractory disease. The nature of the primary oncogenic event(s) remains unknown and is the major unresolved issue in HCL.</description><identifier>ISSN: 1591-8890</identifier><identifier>EISSN: 1591-9528</identifier><identifier>DOI: 10.1007/s10238-004-0046-z</identifier><identifier>PMID: 15599661</identifier><identifier>CODEN: CEMLBA</identifier><language>eng</language><publisher>Italy: Springer Nature B.V</publisher><subject>Chemotherapy ; Diagnosis, Differential ; Humans ; Leukemia ; Leukemia, Hairy Cell - diagnosis ; Leukemia, Hairy Cell - drug therapy ; Leukemia, Hairy Cell - pathology ; Leukemia, Hairy Cell - physiopathology ; Medical diagnosis ; Medical treatment</subject><ispartof>Clinical and experimental medicine, 2004-12, Vol.4 (3), p.132-138</ispartof><rights>Copyright Springer-Verlag 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c326t-47ac47386f3755b792aabc3d13bb29a83d051fa1e5c77330f94927fda4d42dfd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15599661$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Allsup, D J</creatorcontrib><creatorcontrib>Cawley, J C</creatorcontrib><title>Diagnosis, biology and treatment of hairy-cell leukaemia</title><title>Clinical and experimental medicine</title><addtitle>Clin Exp Med</addtitle><description>Hairy-cell leukaemia (HCL) is usually readily diagnosed by seeing typical hairy cells (HCs) in the blood film. 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The nature of the primary oncogenic event(s) remains unknown and is the major unresolved issue in HCL.</description><subject>Chemotherapy</subject><subject>Diagnosis, Differential</subject><subject>Humans</subject><subject>Leukemia</subject><subject>Leukemia, Hairy Cell - diagnosis</subject><subject>Leukemia, Hairy Cell - drug therapy</subject><subject>Leukemia, Hairy Cell - pathology</subject><subject>Leukemia, Hairy Cell - physiopathology</subject><subject>Medical diagnosis</subject><subject>Medical treatment</subject><issn>1591-8890</issn><issn>1591-9528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkD9PwzAUxC0EoqXwAVhQxMBEwPaLY3tE5a9UiQVmy4ntkpLExU6G9tOTqJGQGE7vDXen0w-hS4LvCMb8PhJMQaQYZ6PydH-E5oRJkkpGxfH0CyHxDJ3FuMGYMAH4FM0IY1LmOZkj8VjpdetjFW-TovK1X-8S3ZqkC1Z3jW27xLvkS1dhl5a2rpPa9t_aNpU-RydO19FeTHeBPp-fPpav6er95W35sEpLoHmXZlyXGQeRO-CMFVxSrYsSDIGioFILMJgRp4llJecA2MlMUu6MzkxGjTOwQDeH3m3wP72NnWqqOE7RrfV9VDknHNMhukDX_4wb34d22KYoYA4MZDaYyMFUBh9jsE5tQ9XosFMEq5GpOjBVA89RudoPmaupuC8aa_4SE0T4BabDcOg</recordid><startdate>200412</startdate><enddate>200412</enddate><creator>Allsup, D J</creator><creator>Cawley, J C</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>200412</creationdate><title>Diagnosis, biology and treatment of hairy-cell leukaemia</title><author>Allsup, D J ; Cawley, J C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-47ac47386f3755b792aabc3d13bb29a83d051fa1e5c77330f94927fda4d42dfd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Chemotherapy</topic><topic>Diagnosis, Differential</topic><topic>Humans</topic><topic>Leukemia</topic><topic>Leukemia, Hairy Cell - diagnosis</topic><topic>Leukemia, Hairy Cell - drug therapy</topic><topic>Leukemia, Hairy Cell - pathology</topic><topic>Leukemia, Hairy Cell - physiopathology</topic><topic>Medical diagnosis</topic><topic>Medical treatment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Allsup, D J</creatorcontrib><creatorcontrib>Cawley, J C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Allsup, D J</au><au>Cawley, J C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnosis, biology and treatment of hairy-cell leukaemia</atitle><jtitle>Clinical and experimental medicine</jtitle><addtitle>Clin Exp Med</addtitle><date>2004-12</date><risdate>2004</risdate><volume>4</volume><issue>3</issue><spage>132</spage><epage>138</epage><pages>132-138</pages><issn>1591-8890</issn><eissn>1591-9528</eissn><coden>CEMLBA</coden><abstract>Hairy-cell leukaemia (HCL) is usually readily diagnosed by seeing typical hairy cells (HCs) in the blood film. The diagnosis is then confirmed by tartrate-resistant acid phosphatase staining, marker analysis, and bone marrow examination. HCs are clonal mature memory B cells with specific features of activation. This HC activation is responsible for many of the pathological features of the disease, including its distinctive bone marrow fibrosis, splenic red pulp invasion, and pseudo-sinus formation. Chlorodeoxyadenasine is the treatment of first choice. Deoxycoformycin and rituximab are useful for the treatment of relapsed/refractory disease. The nature of the primary oncogenic event(s) remains unknown and is the major unresolved issue in HCL.</abstract><cop>Italy</cop><pub>Springer Nature B.V</pub><pmid>15599661</pmid><doi>10.1007/s10238-004-0046-z</doi><tpages>7</tpages></addata></record> |
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| subjects | Chemotherapy Diagnosis, Differential Humans Leukemia Leukemia, Hairy Cell - diagnosis Leukemia, Hairy Cell - drug therapy Leukemia, Hairy Cell - pathology Leukemia, Hairy Cell - physiopathology Medical diagnosis Medical treatment |
| title | Diagnosis, biology and treatment of hairy-cell leukaemia |
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