Discovery of Pyrano[3,4-b]indoles as Potent and Selective HCV NS5B Polymerase Inhibitors
A novel series of HCV NS5B RNA-dependent RNA polymerase inhibitors containing a pyrano[3,4-b]indole scaffold is described leading to the discovery of compound 16, a highly potent and selective inhibitor that is active in the replicon system.
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| Veröffentlicht in: | Journal of medicinal chemistry 2004-12, Vol.47 (26), p.6603-6608 |
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| container_end_page | 6608 |
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| container_issue | 26 |
| container_start_page | 6603 |
| container_title | Journal of medicinal chemistry |
| container_volume | 47 |
| creator | Gopalsamy, Ariamala Lim, Kitae Ciszewski, Gregory Park, Kaapjoo Ellingboe, John W Bloom, Jonathan Insaf, Shabana Upeslacis, Janis Mansour, Tarek S Krishnamurthy, Girija Damarla, Murthy Pyatski, Yelena Ho, Douglas Howe, Anita Y. M Orlowski, Mark Feld, Boris O'Connell, John |
| description | A novel series of HCV NS5B RNA-dependent RNA polymerase inhibitors containing a pyrano[3,4-b]indole scaffold is described leading to the discovery of compound 16, a highly potent and selective inhibitor that is active in the replicon system. |
| doi_str_mv | 10.1021/jm0401255 |
| format | Article |
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Drug treatments</subject><subject>Pyrans - chemical synthesis</subject><subject>Pyrans - chemistry</subject><subject>Stereoisomerism</subject><subject>Structure-Activity Relationship</subject><subject>Viral Nonstructural Proteins - antagonists & inhibitors</subject><subject>Viral Nonstructural Proteins - chemistry</subject><issn>0022-2623</issn><issn>1520-4804</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0NGKEzEUBuAgLm5dvfAFJDcKgrOeJJOZzOVatbuw1EKriCIhTU5w6sxkTabL9u3N0rK9EbzKgfPxk_MT8oLBOQPO3m16KIFxKR-RCZMcilJB-ZhMADgveMXFKXma0gYABOPiCTllUioFjZyQbx_aZMMtxh0Nni520Qzhh3hbFuuf7eBCh4maRBdhxGGkZnB0iR3asb1Fejn9SudL-T5vu12P0SSkV8Ovdt2OIaZn5MSbLuHzw3tGvnz6uJpeFtefZ1fTi-vCCF6PhXfWYlN7KVweS8uZZwqcqZxgTvnGlBVDAcLWvlbSoEPOUSksEUwjGxRn5PU-9yaGP1tMo-7zRdh1ZsCwTbqqWQ28av4LWSNUpRqe4Zs9tDGkFNHrm9j2Ju40A33ft37oO9uXh9Dtukd3lIeCM3h1ACZZ0_ncr23T0VWi4iAhu2Lv2jTi3cPexN_5AlFLvVos9Wr-fbaYNXNdH3ONTXoTtnHIJf_jg38BJL-hwQ</recordid><startdate>20041216</startdate><enddate>20041216</enddate><creator>Gopalsamy, Ariamala</creator><creator>Lim, Kitae</creator><creator>Ciszewski, Gregory</creator><creator>Park, Kaapjoo</creator><creator>Ellingboe, John W</creator><creator>Bloom, Jonathan</creator><creator>Insaf, Shabana</creator><creator>Upeslacis, Janis</creator><creator>Mansour, Tarek S</creator><creator>Krishnamurthy, Girija</creator><creator>Damarla, Murthy</creator><creator>Pyatski, Yelena</creator><creator>Ho, Douglas</creator><creator>Howe, Anita Y. 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| identifier | ISSN: 0022-2623 |
| ispartof | Journal of medicinal chemistry, 2004-12, Vol.47 (26), p.6603-6608 |
| issn | 0022-2623 1520-4804 |
| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Biological and medical sciences Crystallography, X-Ray DNA-Directed RNA Polymerases - antagonists & inhibitors DNA-Directed RNA Polymerases - chemistry Hepacivirus - enzymology Hepatitis C virus Indoles - chemical synthesis Indoles - chemistry Medical sciences Pharmacology. Drug treatments Pyrans - chemical synthesis Pyrans - chemistry Stereoisomerism Structure-Activity Relationship Viral Nonstructural Proteins - antagonists & inhibitors Viral Nonstructural Proteins - chemistry |
| title | Discovery of Pyrano[3,4-b]indoles as Potent and Selective HCV NS5B Polymerase Inhibitors |
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