A common variant on chromosome 11q13 is associated with atopic dermatitis
We conducted a genome-wide association study in 939 individuals with atopic dermatitis and 975 controls as well as 270 complete nuclear families with two affected siblings. SNPs consistently associated with atopic dermatitis in both discovery sets were then investigated in two additional independent...
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| Veröffentlicht in: | Nature genetics 2009-05, Vol.41 (5), p.596-601 |
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| creator | Patone, Giannino Macek, Milan Wahn, Ulrich Piskackova, Tereza Franke, Andre Ruether, Andreas Bauerfeind, Anja Esparza-Gordillo, Jorge Ruschendorf, Franz Kerscher, Tamara Vogler, Rainer Schulz, Florian Lee, Young-Ae Ciechanowicz, Andrzej Fölster-Holst, Regina Hubner, Norbert Novak, Natalija Marenholz, Ingo Heath, Simon Rohde, Klaus Schreiber, Stefan Kurek, Michael Lee-Kirsch, Min-Ae Illig, Thomas Weidinger, Stephan Baurecht, Hansjörg Rodriguez, Elke |
| description | We conducted a genome-wide association study in 939 individuals with atopic dermatitis and 975 controls as well as 270 complete nuclear families with two affected siblings. SNPs consistently associated with atopic dermatitis in both discovery sets were then investigated in two additional independent replication sets totalling 2,637 cases and 3,957 controls. Highly significant association was found with allele A of rs7927894 on chromosome 11q13.5, located 38 kb downstream of C11orf30 (Pcombined = 7.6 × 10−10). Approximately 13% of individuals of European origin are homozygous for rs7927894[A], and their risk of developing atopic dermatitis is 1.47 times that of noncarriers. |
| doi_str_mv | 10.1038/ng.347 |
| format | Article |
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SNPs consistently associated with atopic dermatitis in both discovery sets were then investigated in two additional independent replication sets totalling 2,637 cases and 3,957 controls. Highly significant association was found with allele A of rs7927894 on chromosome 11q13.5, located 38 kb downstream of C11orf30 (Pcombined = 7.6 × 10−10). Approximately 13% of individuals of European origin are homozygous for rs7927894[A], and their risk of developing atopic dermatitis is 1.47 times that of noncarriers.</description><identifier>ISSN: 1061-4036</identifier><identifier>EISSN: 1546-1718</identifier><identifier>DOI: 10.1038/ng.347</identifier><identifier>PMID: 19349984</identifier><identifier>CODEN: NGENEC</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Adolescent ; Agriculture ; Allergic diseases ; Animal Genetics and Genomics ; Atopic dermatitis ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Care and treatment ; Case-Control Studies ; Chromosomes ; Chromosomes, Human, Pair 11 - genetics ; Crohn's disease ; Data base management ; Dermatitis ; Dermatitis, Atopic - genetics ; DNA damage ; DNA repair ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Function ; Genetic aspects ; Genetic Predisposition to Disease ; Genetic susceptibility ; Genetic Variation ; Genetics ; Genetics of eukaryotes. Biological and molecular evolution ; Genome, Human ; Health aspects ; Human Genetics ; Humans ; Immunopathology ; Independent sample ; letter ; Linkage Disequilibrium ; Male ; Medical sciences ; Polymorphism, Single Nucleotide ; Principal components analysis ; Risk factors ; Single nucleotide polymorphisms ; Skin allergic diseases. 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SNPs consistently associated with atopic dermatitis in both discovery sets were then investigated in two additional independent replication sets totalling 2,637 cases and 3,957 controls. Highly significant association was found with allele A of rs7927894 on chromosome 11q13.5, located 38 kb downstream of C11orf30 (Pcombined = 7.6 × 10−10). Approximately 13% of individuals of European origin are homozygous for rs7927894[A], and their risk of developing atopic dermatitis is 1.47 times that of noncarriers.</description><subject>Adolescent</subject><subject>Agriculture</subject><subject>Allergic diseases</subject><subject>Animal Genetics and Genomics</subject><subject>Atopic dermatitis</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Chromosomes</subject><subject>Chromosomes, Human, Pair 11 - genetics</subject><subject>Crohn's disease</subject><subject>Data base management</subject><subject>Dermatitis</subject><subject>Dermatitis, Atopic - genetics</subject><subject>DNA damage</subject><subject>DNA repair</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Function</subject><subject>Genetic aspects</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetic susceptibility</subject><subject>Genetic Variation</subject><subject>Genetics</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Genome, Human</subject><subject>Health aspects</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>Independent sample</subject><subject>letter</subject><subject>Linkage Disequilibrium</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Principal components analysis</subject><subject>Risk factors</subject><subject>Single nucleotide polymorphisms</subject><subject>Skin allergic diseases. Stinging insect allergies</subject><subject>Studies</subject><subject>Young Adult</subject><issn>1061-4036</issn><issn>1546-1718</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0lmLFDEQAOBGFPdQf4FIo6j40GOqcz8Oi8fAwoLXa8ik071ZppPZJK3rvzfDNLuMCkoeUiRfVahQVfUE0AIQFm_9sMCE36uOgRLWAAdxv8SIQUMQZkfVSUpXCAEhSDysjkBiIqUgx9VqWZswjsHX33V02ue6hOYyhjGkMNoa4Bpw7VKtUwrG6Wy7-ofLl7XOYetM3dk46uyyS4-qB73eJPt43k-rr-_ffTn72JxffFidLc8bQynOjTScMmqgF2vB6VoyEIZYDBIk6XjHGTdaGK6FBLC4M5b1uhO9JBRo2xGNT6tX-7rbGK4nm7IaXTJ2s9HehikpxoFJJtg_YYsoK6_QAp__Bq_CFH1pQrVty2gr2A692KNBb6xyvg85arOrqJYgJZYcCVzU4i-qrM6OzgRve1fODxLeHCQUk-1NHvSUklp9_vT_9uLboZ2bNzGkFG2vttGNOv5UgNRuYpQfVJmYAp_NzU_r0XZ3bB6RAl7OQCejN33U3rh061ogGAjfFXq9d6lc-cHGu1_848mne-l1nqK9LTVf_wJXttn6</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Patone, Giannino</creator><creator>Macek, Milan</creator><creator>Wahn, Ulrich</creator><creator>Piskackova, Tereza</creator><creator>Franke, Andre</creator><creator>Ruether, Andreas</creator><creator>Bauerfeind, Anja</creator><creator>Esparza-Gordillo, Jorge</creator><creator>Ruschendorf, Franz</creator><creator>Kerscher, Tamara</creator><creator>Vogler, Rainer</creator><creator>Schulz, Florian</creator><creator>Lee, Young-Ae</creator><creator>Ciechanowicz, Andrzej</creator><creator>Fölster-Holst, Regina</creator><creator>Hubner, Norbert</creator><creator>Novak, Natalija</creator><creator>Marenholz, Ingo</creator><creator>Heath, Simon</creator><creator>Rohde, Klaus</creator><creator>Schreiber, Stefan</creator><creator>Kurek, Michael</creator><creator>Lee-Kirsch, Min-Ae</creator><creator>Illig, Thomas</creator><creator>Weidinger, Stephan</creator><creator>Baurecht, Hansjörg</creator><creator>Rodriguez, Elke</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20090501</creationdate><title>A common variant on chromosome 11q13 is associated with atopic dermatitis</title><author>Patone, Giannino ; Macek, Milan ; Wahn, Ulrich ; Piskackova, Tereza ; Franke, Andre ; Ruether, Andreas ; Bauerfeind, Anja ; Esparza-Gordillo, Jorge ; Ruschendorf, Franz ; Kerscher, Tamara ; Vogler, Rainer ; Schulz, Florian ; Lee, Young-Ae ; Ciechanowicz, Andrzej ; Fölster-Holst, Regina ; Hubner, Norbert ; Novak, Natalija ; Marenholz, Ingo ; Heath, Simon ; Rohde, Klaus ; Schreiber, Stefan ; Kurek, Michael ; Lee-Kirsch, Min-Ae ; Illig, Thomas ; Weidinger, Stephan ; Baurecht, Hansjörg ; Rodriguez, Elke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c553t-9c7565c1f8b875b9618c4e319194d7d767ca8c7a8911e3dce6fad8f945152d4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Agriculture</topic><topic>Allergic diseases</topic><topic>Animal Genetics and Genomics</topic><topic>Atopic dermatitis</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Care and treatment</topic><topic>Case-Control Studies</topic><topic>Chromosomes</topic><topic>Chromosomes, Human, Pair 11 - genetics</topic><topic>Crohn's disease</topic><topic>Data base management</topic><topic>Dermatitis</topic><topic>Dermatitis, Atopic - genetics</topic><topic>DNA damage</topic><topic>DNA repair</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Function</topic><topic>Genetic aspects</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetic susceptibility</topic><topic>Genetic Variation</topic><topic>Genetics</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Genome, Human</topic><topic>Health aspects</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>Independent sample</topic><topic>letter</topic><topic>Linkage Disequilibrium</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Principal components analysis</topic><topic>Risk factors</topic><topic>Single nucleotide polymorphisms</topic><topic>Skin allergic diseases. 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| fulltext | fulltext |
| identifier | ISSN: 1061-4036 |
| ispartof | Nature genetics, 2009-05, Vol.41 (5), p.596-601 |
| issn | 1061-4036 1546-1718 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67169686 |
| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | Adolescent Agriculture Allergic diseases Animal Genetics and Genomics Atopic dermatitis Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Care and treatment Case-Control Studies Chromosomes Chromosomes, Human, Pair 11 - genetics Crohn's disease Data base management Dermatitis Dermatitis, Atopic - genetics DNA damage DNA repair Female Fundamental and applied biological sciences. Psychology Gene Function Genetic aspects Genetic Predisposition to Disease Genetic susceptibility Genetic Variation Genetics Genetics of eukaryotes. Biological and molecular evolution Genome, Human Health aspects Human Genetics Humans Immunopathology Independent sample letter Linkage Disequilibrium Male Medical sciences Polymorphism, Single Nucleotide Principal components analysis Risk factors Single nucleotide polymorphisms Skin allergic diseases. Stinging insect allergies Studies Young Adult |
| title | A common variant on chromosome 11q13 is associated with atopic dermatitis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T06%3A39%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20common%20variant%20on%20chromosome%2011q13%20is%20associated%20with%20atopic%20dermatitis&rft.jtitle=Nature%20genetics&rft.au=Patone,%20Giannino&rft.date=2009-05-01&rft.volume=41&rft.issue=5&rft.spage=596&rft.epage=601&rft.pages=596-601&rft.issn=1061-4036&rft.eissn=1546-1718&rft.coden=NGENEC&rft_id=info:doi/10.1038/ng.347&rft_dat=%3Cgale_proqu%3EA199397083%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=222652865&rft_id=info:pmid/19349984&rft_galeid=A199397083&rfr_iscdi=true |