Efficient DNA Binding by Optically Pure Ruthenium Tris(bipyridyl) Complexes Incorporating Carboxylic Functionalities. Solution and Structural Analysis

Herein, we report on the binding of optically pure ruthenium complexes Δ- or Λ-[Ru(bpy)2(L−L)][PF6]2 [L−L = Hcmbpy = 4-carboxy-4‘-methyl-2,2‘-bipyridine (1), L−L = H2dcbpy = 4,4‘-dicarboxy-2,2‘-bipyridine (2)] to DNA. The binding constants of the two enantiomeric Δ-1 and Λ-1 complexes to DNA were es...

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Veröffentlicht in:	Inorganic chemistry 2004-12, Vol.43 (25), p.7986-7993
Hauptverfasser:	Caspar, Régis, Musatkina, Léna, Tatosyan, Alexander, Amouri, Hani, Gruselle, Michel, Guyard-Duhayon, Carine, Duval, Raphaël, Cordier, Christine
Format:	Artikel
Sprache:	eng
Schlagworte:	2,2'-Dipyridyl - chemistry Algorithms Binding Sites Crystallography, X-Ray DNA - chemistry DNA - metabolism Magnetic Resonance Spectroscopy Models, Molecular Molecular Structure Organometallic Compounds - chemistry Ruthenium - chemistry Spectrophotometry, Infrared Stereoisomerism
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