Autonomous activity of CaMKII is only transiently increased following the induction of long-term potentiation in the rat hippocampus

A major role has been postulated for a maintained increase in the autonomous activity of CaMKII in the expression of long‐term potentiation (LTP). However, attempts to inhibit the expression of LTP with CaMKII inhibitors have yielded inconsistent results. Here we compare the changes in CaMKII autono...

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Veröffentlicht in:	The European journal of neuroscience 2004-12, Vol.20 (11), p.3063-3072
Hauptverfasser:	Lengyel, I., Voss, K., Cammarota, M., Bradshaw, K., Brent, V., Murphy, K. P. S. J., Giese, K. P., Rostas, J. A. P., Bliss, T. V. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western - methods Calcium-Calmodulin-Dependent Protein Kinase Type 2 Calcium-Calmodulin-Dependent Protein Kinases - metabolism CaMKII Electric Stimulation Enzyme Activation Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - radiation effects Hippocampus - anatomy & histology Hippocampus - drug effects Hippocampus - physiology Hippocampus - radiation effects In Vitro Techniques long-term potentiation Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Long-Term Potentiation - radiation effects Male Phosphorylation - drug effects Phosphorylation - radiation effects Potassium - pharmacology Potassium Channel Blockers - pharmacology protein kinases protein phosphatases protein phosphorylation Rats Rats, Sprague-Dawley Tetraethylammonium - pharmacology Threonine - metabolism Time Factors
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