Effects of β-Adrenoreceptor Blockade During Chronic Exercise on Contextual Fear Conditioning and mRNA for Galanin and Brain-Derived Neurotrophic Factor
The authors examined the effects of activity wheel running (AWR) and propranolol on contextual fear conditioning (CFC) and messenger RNA (mRNA) for galanin (GAL) in the locus coeruleus (LC) and brain-derived neurotrophic factor (BDNF) in the hippocampal formation (HF) in rats. Freezing behavior duri...
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| Veröffentlicht in: | Behavioral neuroscience 2004-12, Vol.118 (6), p.1378-1390 |
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| creator | Van Hoomissen, Jacqueline D Holmes, Philip V Zellner, Andrew S Poudevigne, Adeline M Dishman, Rod K |
| description | The authors examined the effects of activity wheel running (AWR) and propranolol on contextual fear conditioning (CFC) and messenger RNA (mRNA) for galanin (GAL) in the locus coeruleus (LC) and brain-derived neurotrophic factor (BDNF) in the hippocampal formation (HF) in rats. Freezing behavior during the testing session of the CFC protocol was elevated in the AWR-placebo group compared to sedentary-placebo and AWR-propranolol groups. AWR increased GAL mRNA in the LC. CFC increased BDNF mRNA in the HF. These results suggest that exercise enhances CFC and that antagonism of the β-adrenoreceptors attenuates this effect. The exercise-related induction of GAL gene expression in the LC may influence noradrenergic transmission to facilitate CFC. |
| doi_str_mv | 10.1037/0735-7044.118.6.1378 |
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Freezing behavior during the testing session of the CFC protocol was elevated in the AWR-placebo group compared to sedentary-placebo and AWR-propranolol groups. AWR increased GAL mRNA in the LC. CFC increased BDNF mRNA in the HF. These results suggest that exercise enhances CFC and that antagonism of the β-adrenoreceptors attenuates this effect. The exercise-related induction of GAL gene expression in the LC may influence noradrenergic transmission to facilitate CFC.</description><identifier>ISSN: 0735-7044</identifier><identifier>EISSN: 1939-0084</identifier><identifier>DOI: 10.1037/0735-7044.118.6.1378</identifier><identifier>PMID: 15598146</identifier><language>eng</language><publisher>United States: American Psychological Association</publisher><subject>Adrenergic beta-Antagonists - pharmacology ; Analysis of Variance ; Animal ; Animal Locomotion ; Animals ; Autoradiography - methods ; Behavior, Animal ; Brain ; Brain Derived Neurotrophic Factor ; Brain-Derived Neurotrophic Factor - genetics ; Brain-Derived Neurotrophic Factor - metabolism ; Conditioned Fear ; Conditioning (Psychology) - drug effects ; Corticosterone - blood ; Effects ; Electroshock - adverse effects ; Exercise ; Fear ; Fear & phobias ; Freezing Reaction, Cataleptic - drug effects ; Galanin - genetics ; Galanin - metabolism ; Gene Expression Regulation - drug effects ; Hippocampus ; In Situ Hybridization - methods ; Locus Ceruleus ; Male ; Motor Activity - drug effects ; Nerve Growth Factor ; Neurotrophic Factor ; Peptides ; Propranolol ; Propranolol - pharmacology ; Radioimmunoassay - methods ; Rats ; Rats, Long-Evans ; Ribonucleic Acid ; RNA ; RNA, Messenger - metabolism ; Running ; Time Factors</subject><ispartof>Behavioral neuroscience, 2004-12, Vol.118 (6), p.1378-1390</ispartof><rights>2004 American Psychological Association</rights><rights>Copyright American Psychological Association Dec 2004</rights><rights>2004, American Psychological Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a419t-67c7a8b304d74124f26e8141749fff4afc855e9da8214bba7b30f5ed0bcd5413</citedby><cites>FETCH-LOGICAL-a419t-67c7a8b304d74124f26e8141749fff4afc855e9da8214bba7b30f5ed0bcd5413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15598146$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van Hoomissen, Jacqueline D</creatorcontrib><creatorcontrib>Holmes, Philip V</creatorcontrib><creatorcontrib>Zellner, Andrew S</creatorcontrib><creatorcontrib>Poudevigne, Adeline M</creatorcontrib><creatorcontrib>Dishman, Rod K</creatorcontrib><title>Effects of β-Adrenoreceptor Blockade During Chronic Exercise on Contextual Fear Conditioning and mRNA for Galanin and Brain-Derived Neurotrophic Factor</title><title>Behavioral neuroscience</title><addtitle>Behav Neurosci</addtitle><description>The authors examined the effects of activity wheel running (AWR) and propranolol on contextual fear conditioning (CFC) and messenger RNA (mRNA) for galanin (GAL) in the locus coeruleus (LC) and brain-derived neurotrophic factor (BDNF) in the hippocampal formation (HF) in rats. Freezing behavior during the testing session of the CFC protocol was elevated in the AWR-placebo group compared to sedentary-placebo and AWR-propranolol groups. AWR increased GAL mRNA in the LC. CFC increased BDNF mRNA in the HF. These results suggest that exercise enhances CFC and that antagonism of the β-adrenoreceptors attenuates this effect. The exercise-related induction of GAL gene expression in the LC may influence noradrenergic transmission to facilitate CFC.</description><subject>Adrenergic beta-Antagonists - pharmacology</subject><subject>Analysis of Variance</subject><subject>Animal</subject><subject>Animal Locomotion</subject><subject>Animals</subject><subject>Autoradiography - methods</subject><subject>Behavior, Animal</subject><subject>Brain</subject><subject>Brain Derived Neurotrophic Factor</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Brain-Derived Neurotrophic Factor - metabolism</subject><subject>Conditioned Fear</subject><subject>Conditioning (Psychology) - drug effects</subject><subject>Corticosterone - blood</subject><subject>Effects</subject><subject>Electroshock - adverse effects</subject><subject>Exercise</subject><subject>Fear</subject><subject>Fear & phobias</subject><subject>Freezing Reaction, Cataleptic - drug effects</subject><subject>Galanin - genetics</subject><subject>Galanin - metabolism</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Hippocampus</subject><subject>In Situ Hybridization - methods</subject><subject>Locus Ceruleus</subject><subject>Male</subject><subject>Motor Activity - drug effects</subject><subject>Nerve Growth Factor</subject><subject>Neurotrophic Factor</subject><subject>Peptides</subject><subject>Propranolol</subject><subject>Propranolol - pharmacology</subject><subject>Radioimmunoassay - methods</subject><subject>Rats</subject><subject>Rats, Long-Evans</subject><subject>Ribonucleic Acid</subject><subject>RNA</subject><subject>RNA, Messenger - metabolism</subject><subject>Running</subject><subject>Time Factors</subject><issn>0735-7044</issn><issn>1939-0084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1uFDEQhVsIRIbADRCyWLDrwe7273IymQlIUZBQ9pbbLhOHnnZjd6PkJpyDg3CmeJIRQSxgZbn0vecq16uq1wQvCW7FeyxaVgtM6ZIQueRL0gr5pFoQ1aoaY0mfVovfyFH1IudrjDHFlD2vjghjShLKF9WPjfdgp4yiR79-1iuXYIgJLIxTTOikj_arcYBO5xSGL2h9leIQLNrcQLIhA4oDWsdhgptpNj3agkn7uwtTKFwRmMGh3eeLFfLF7cz0plTviyfJhKE-hRS-g0MXMKc4pTheFfOtseXtl9Uzb_oMrw7ncXW53VyuP9Tnn84-rlfntaFETTUXVhjZtZg6QUlDfcOhTEYEVd57aryVjIFyRjaEdp0RBfUMHO6sY5S0x9W7B9sxxW8z5EnvQrbQl04hzllzQbgs3_lfkCgqVcNwAd_-BV7HOQ1lBs0JbZUQXP4LanArFaO8LRB9gGyKOSfwekxhZ9KtJljvM6D3C9b7BeuSAc31PgNF9ubgPXc7cI-iw9IfRzGj0WO-tSZNwfaQdTfAn0537_a6fQ</recordid><startdate>20041201</startdate><enddate>20041201</enddate><creator>Van Hoomissen, Jacqueline D</creator><creator>Holmes, Philip V</creator><creator>Zellner, Andrew S</creator><creator>Poudevigne, Adeline M</creator><creator>Dishman, Rod K</creator><general>American Psychological Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7TM</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>20041201</creationdate><title>Effects of β-Adrenoreceptor Blockade During Chronic Exercise on Contextual Fear Conditioning and mRNA for Galanin and Brain-Derived Neurotrophic Factor</title><author>Van Hoomissen, Jacqueline D ; Holmes, Philip V ; Zellner, Andrew S ; Poudevigne, Adeline M ; Dishman, Rod K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a419t-67c7a8b304d74124f26e8141749fff4afc855e9da8214bba7b30f5ed0bcd5413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adrenergic beta-Antagonists - pharmacology</topic><topic>Analysis of Variance</topic><topic>Animal</topic><topic>Animal Locomotion</topic><topic>Animals</topic><topic>Autoradiography - methods</topic><topic>Behavior, Animal</topic><topic>Brain</topic><topic>Brain Derived Neurotrophic Factor</topic><topic>Brain-Derived Neurotrophic Factor - genetics</topic><topic>Brain-Derived Neurotrophic Factor - metabolism</topic><topic>Conditioned Fear</topic><topic>Conditioning (Psychology) - drug effects</topic><topic>Corticosterone - blood</topic><topic>Effects</topic><topic>Electroshock - adverse effects</topic><topic>Exercise</topic><topic>Fear</topic><topic>Fear & phobias</topic><topic>Freezing Reaction, Cataleptic - drug effects</topic><topic>Galanin - genetics</topic><topic>Galanin - metabolism</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Hippocampus</topic><topic>In Situ Hybridization - methods</topic><topic>Locus Ceruleus</topic><topic>Male</topic><topic>Motor Activity - drug effects</topic><topic>Nerve Growth Factor</topic><topic>Neurotrophic Factor</topic><topic>Peptides</topic><topic>Propranolol</topic><topic>Propranolol - pharmacology</topic><topic>Radioimmunoassay - methods</topic><topic>Rats</topic><topic>Rats, Long-Evans</topic><topic>Ribonucleic Acid</topic><topic>RNA</topic><topic>RNA, Messenger - metabolism</topic><topic>Running</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van Hoomissen, Jacqueline D</creatorcontrib><creatorcontrib>Holmes, Philip V</creatorcontrib><creatorcontrib>Zellner, Andrew S</creatorcontrib><creatorcontrib>Poudevigne, Adeline M</creatorcontrib><creatorcontrib>Dishman, Rod K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>APA PsycArticles®</collection><collection>ProQuest One Psychology</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioral neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van Hoomissen, Jacqueline D</au><au>Holmes, Philip V</au><au>Zellner, Andrew S</au><au>Poudevigne, Adeline M</au><au>Dishman, Rod K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of β-Adrenoreceptor Blockade During Chronic Exercise on Contextual Fear Conditioning and mRNA for Galanin and Brain-Derived Neurotrophic Factor</atitle><jtitle>Behavioral neuroscience</jtitle><addtitle>Behav Neurosci</addtitle><date>2004-12-01</date><risdate>2004</risdate><volume>118</volume><issue>6</issue><spage>1378</spage><epage>1390</epage><pages>1378-1390</pages><issn>0735-7044</issn><eissn>1939-0084</eissn><abstract>The authors examined the effects of activity wheel running (AWR) and propranolol on contextual fear conditioning (CFC) and messenger RNA (mRNA) for galanin (GAL) in the locus coeruleus (LC) and brain-derived neurotrophic factor (BDNF) in the hippocampal formation (HF) in rats. Freezing behavior during the testing session of the CFC protocol was elevated in the AWR-placebo group compared to sedentary-placebo and AWR-propranolol groups. AWR increased GAL mRNA in the LC. CFC increased BDNF mRNA in the HF. These results suggest that exercise enhances CFC and that antagonism of the β-adrenoreceptors attenuates this effect. The exercise-related induction of GAL gene expression in the LC may influence noradrenergic transmission to facilitate CFC.</abstract><cop>United States</cop><pub>American Psychological Association</pub><pmid>15598146</pmid><doi>10.1037/0735-7044.118.6.1378</doi><tpages>13</tpages></addata></record> |
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| subjects | Adrenergic beta-Antagonists - pharmacology Analysis of Variance Animal Animal Locomotion Animals Autoradiography - methods Behavior, Animal Brain Brain Derived Neurotrophic Factor Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Conditioned Fear Conditioning (Psychology) - drug effects Corticosterone - blood Effects Electroshock - adverse effects Exercise Fear Fear & phobias Freezing Reaction, Cataleptic - drug effects Galanin - genetics Galanin - metabolism Gene Expression Regulation - drug effects Hippocampus In Situ Hybridization - methods Locus Ceruleus Male Motor Activity - drug effects Nerve Growth Factor Neurotrophic Factor Peptides Propranolol Propranolol - pharmacology Radioimmunoassay - methods Rats Rats, Long-Evans Ribonucleic Acid RNA RNA, Messenger - metabolism Running Time Factors |
| title | Effects of β-Adrenoreceptor Blockade During Chronic Exercise on Contextual Fear Conditioning and mRNA for Galanin and Brain-Derived Neurotrophic Factor |
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