Cardiomyocyte Apoptosis Triggered by RAFTK/pyk2 via Src Kinase Is Antagonized by Paxillin

Altered cellular adhesion and apoptotic signaling in cardiac remodeling requires coordinated regulation of multiple constituent proteins that comprise cytoskeletal focal adhesions. One such protein activated by cardiac remodeling is related adhesion focal tyrosine kinase (RAFTK, also known as pyk2)....

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Veröffentlicht in:	The Journal of biological chemistry 2004-12, Vol.279 (51), p.53516-53523
Hauptverfasser:	Melendez, Jaime, Turner, Christopher, Avraham, Hava, Steinberg, Susan F., Schaefer, Erik, Sussman, Mark A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Animals Animals, Newborn Apoptosis Binding Sites Caspase 3 Caspases - metabolism Cell Adhesion Cell Cycle Proteins - metabolism Cells, Cultured Cytoplasm - metabolism Cytoskeletal Proteins - metabolism Cytoskeletal Proteins - pharmacology Cytoskeleton - metabolism DNA - metabolism DNA Fragmentation DNA, Complementary - metabolism Dual Specificity Phosphatase 1 Enzyme Inhibitors - pharmacology Focal Adhesion Kinase 2 Genes, Dominant Immediate-Early Proteins - metabolism Immunoblotting JNK Mitogen-Activated Protein Kinases - metabolism Membrane Proteins - metabolism Microscopy, Fluorescence Models, Biological Mutation Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology p38 Mitogen-Activated Protein Kinases - metabolism Paxillin Phenotype Phosphoprotein Phosphatases - metabolism Phosphoproteins - metabolism Phosphoproteins - pharmacology Phosphorylation Protein Phosphatase 1 Protein Tyrosine Phosphatases - metabolism Protein-Tyrosine Kinases - metabolism Rats Signal Transduction src-Family Kinases - antagonists & inhibitors src-Family Kinases - metabolism Staurosporine - pharmacology Time Factors Tyrosine - chemistry Vinculin - metabolism
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