Increase of intracellular Ca2+ by P2X and P2Y receptor-subtypes in cultured cortical astroglia of the rat

Abstract Astrocytes express purinergic receptors that are involved in glial–neuronal cell communication. Experiments were conducted to characterize the expression of functional P2X/P2Y nucleotide receptors in glial cells of mixed cortical cell cultures of the rat. The vast majority of these cells wa...

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Veröffentlicht in:	Neuroscience 2009-06, Vol.160 (4), p.767-783
Hauptverfasser:	Fischer, W, Appelt, K, Grohmann, M, Franke, H, Nörenberg, W, Illes, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - pharmacology Animals Astrocytes - metabolism Astrocytes - ultrastructure Biological and medical sciences Calcium - metabolism Calcium Signaling - drug effects Calcium Signaling - physiology Calcium-Transporting ATPases - antagonists & inhibitors Calcium-Transporting ATPases - metabolism Cells, Cultured Cerebral Cortex - cytology Cerebral Cortex - metabolism Coculture Techniques Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Glial Fibrillary Acidic Protein - metabolism Immunohistochemistry Intracellular Fluid - drug effects Intracellular Fluid - metabolism Neurology Nucleotides - metabolism Nucleotides - pharmacology Purinergic P2 Receptor Agonists Rats Rats, Wistar Receptors, G-Protein-Coupled - drug effects Receptors, G-Protein-Coupled - metabolism Receptors, Purinergic P2 - metabolism Receptors, Purinergic P2X Receptors, Purinergic P2Y12 Signal Transduction - drug effects Signal Transduction - physiology Up-Regulation - physiology Vertebrates: nervous system and sense organs
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