The Human DiGeorge Syndrome Critical Region Gene 8 and Its D. melanogaster Homolog Are Required for miRNA Biogenesis

MicroRNAs (miRNAs) represent a family of small noncoding RNAs that are found in plants and animals (for recent reviews, see [1–5]). miRNAs are expressed in a developmentally and tissue-specific manner and regulate the translational efficiency and stability of partial or fully sequence-complementary...

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Veröffentlicht in:	Current biology 2004-12, Vol.14 (23), p.2162-2167
Hauptverfasser:	Landthaler, Markus, Yalcin, Abdullah, Tuschl, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Northern Blotting, Western Drosophila melanogaster Drosophila melanogaster - genetics Drosophila Proteins - metabolism Gene Components Gene Expression Regulation HeLa Cells Humans MicroRNAs - biosynthesis Oligonucleotides Plasmids - genetics Protein Structure, Tertiary Proteins - genetics Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction Ribonuclease III - metabolism RNA Interference RNA Polymerase II - metabolism RNA, Messenger - metabolism RNA-Binding Proteins
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