Expression of tight-junction-associated proteins in human gastric cancer: downregulation of claudin-4 correlates with tumor aggressiveness and survival

Background Claudin, occludin, and zonula occludens (ZO)-1 are known as tight-junction-associated proteins. The aim of this study was to examine the expression of these proteins in gastric carcinoma. Methods Gastric cancer tissues ( n = 124) were obtained from 124 patients who underwent gastrectomy a...

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Veröffentlicht in:	Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2009-04, Vol.12 (1), p.43-51
Hauptverfasser:	Ohtani, Satoshi, Terashima, Masanori, Satoh, Jun, Soeta, Nobutoshi, Saze, Zenichiroh, Kashimura, Seigo, Ohsuka, Fumihiko, Hoshino, Yutaka, Kogure, Michihiko, Gotoh, Mitsukazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal Surgery Adenocarcinoma - metabolism Adenocarcinoma - mortality Adenocarcinoma - secondary Adolescent Adult Aged Aged, 80 and over Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer Research Claudin-4 Down-Regulation Female Gastric cancer Gastroenterology Gene Expression Regulation, Neoplastic Humans Immunoenzyme Techniques Lymphatic Metastasis Male Medicine Medicine & Public Health Membrane Proteins - genetics Membrane Proteins - metabolism Middle Aged Neoplasm Staging Oncology Original Article Prognosis Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Stomach Neoplasms - metabolism Stomach Neoplasms - mortality Stomach Neoplasms - pathology Surgical Oncology Survival Rate Tissue Array Analysis Young Adult
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