Potent in Vivo Antiangiogenic Effects of GS-101 (5′-TATCCGGAGGGCTCGCCATGCTGCT-3′), an Antisense Oligonucleotide Preventing the Expression of Insulin Receptor Substrate-1

Angiogenesis is a complex phenomenon regulated by both pro- and antiangiogenic factors such as the vascular endothelial growth factor (VEGF), and inflammation may be involved in the process. Although antagonizing VEGF has been proposed as a therapeutic approach to limit corneal angiogenesis, alterna...

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