Use of B-type natriuretic peptide for the management of women with dyspnea

In studies with predominately male patients, B-type natriuretic peptide (BNP) levels have been shown to be helpful in the evaluation and management of patients who present with acute dyspnea. The effect of BNP levels on the management of women has not been defined. This study evaluated a predefined...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The American journal of cardiology 2004-12, Vol.94 (12), p.1510-1514
Hauptverfasser: Mueller, Christian, Laule-Kilian, Kirsten, Scholer, André, Frana, Barbara, Rodriguez, Daniel, Schindler, Christian, Marsch, Stephan, Perruchoud, André P.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1514
container_issue 12
container_start_page 1510
container_title The American journal of cardiology
container_volume 94
creator Mueller, Christian
Laule-Kilian, Kirsten
Scholer, André
Frana, Barbara
Rodriguez, Daniel
Schindler, Christian
Marsch, Stephan
Perruchoud, André P.
description In studies with predominately male patients, B-type natriuretic peptide (BNP) levels have been shown to be helpful in the evaluation and management of patients who present with acute dyspnea. The effect of BNP levels on the management of women has not been defined. This study evaluated a predefined subgroup of 190 women included in a prospective randomized controlled study of BNP testing for emergency diagnosis of acute dyspnea. Patients were randomly assigned to a diagnostic strategy with (n = 93, BNP group) or without (n = 97, control group) the use of BNP levels provided by a rapid bedside assay. Women differed significantly from men in baseline characteristics, symptoms, signs, and final discharge diagnoses. The use of BNP levels decreased the need for hospital admission (73% vs 86%, p = 0.034) and intensive care (12% vs 23%, p = 0.048). Median time to discharge was 6 days in the BNP group versus 10 days in the control group (p = 0.023). Total cost of treatment was $4,781 in the BNP group (95% confidence interval 3,854 to 5,708) versus $6,843 in the control group (95% confidence interval 5,611 to 8,074, p = 0.009). In-hospital mortality rates were 4% in the BNP group and 10% in the control group (p = 0.165). Thus, used in conjunction with other clinical information, rapid measurement of BNP decreased time to discharge and total cost of treatment in women who presented with acute dyspnea.
doi_str_mv 10.1016/j.amjcard.2004.08.029
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67162831</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002914904013797</els_id><sourcerecordid>67162831</sourcerecordid><originalsourceid>FETCH-LOGICAL-c420t-515868fcbf32ef630672d77dacb0c068f2962fafe13ba496a6d02a3beac8a84d3</originalsourceid><addsrcrecordid>eNqFkE2LFDEQhoMo7uzqT1AaQW_dVpLudPdJdHH9YMGLew7VScXNMP1hknaZf2-GaVjw4qlS5HmLl4exVxwqDly931c47g0GWwmAuoKuAtE_YTvetX3Jey6fsh0AiLLndX_BLmPc55XzRj1nF7xpuh5A7dj3u0jF7IpPZTouVEyYgl8DJW-KhZbkLRVuDkW6p2LECX_RSFM6BR7m_CoefLov7DEuE-EL9szhIdLLbV6xu5vPP6-_lrc_vny7_nhbmlpAKhvedKpzZnBSkFMSVCts21o0AxjIP6JXwqEjLgese4XKgkA5EJoOu9rKK_bufHcJ8--VYtKjj4YOB5xoXqNWLVeikzyDb_4B9_MaptxNCwmykX1dZ6g5QybMMQZyegl-xHDUHPTJtN7rzbQ-mdbQ6Ww6515vx9dhJPuY2tRm4O0GYDR4cAEn4-Mjp2Td1upU4MOZo-zsj6ego_E0GbI-kEnazv4_Vf4CKcueLg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>230353944</pqid></control><display><type>article</type><title>Use of B-type natriuretic peptide for the management of women with dyspnea</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Mueller, Christian ; Laule-Kilian, Kirsten ; Scholer, André ; Frana, Barbara ; Rodriguez, Daniel ; Schindler, Christian ; Marsch, Stephan ; Perruchoud, André P.</creator><creatorcontrib>Mueller, Christian ; Laule-Kilian, Kirsten ; Scholer, André ; Frana, Barbara ; Rodriguez, Daniel ; Schindler, Christian ; Marsch, Stephan ; Perruchoud, André P.</creatorcontrib><description>In studies with predominately male patients, B-type natriuretic peptide (BNP) levels have been shown to be helpful in the evaluation and management of patients who present with acute dyspnea. The effect of BNP levels on the management of women has not been defined. This study evaluated a predefined subgroup of 190 women included in a prospective randomized controlled study of BNP testing for emergency diagnosis of acute dyspnea. Patients were randomly assigned to a diagnostic strategy with (n = 93, BNP group) or without (n = 97, control group) the use of BNP levels provided by a rapid bedside assay. Women differed significantly from men in baseline characteristics, symptoms, signs, and final discharge diagnoses. The use of BNP levels decreased the need for hospital admission (73% vs 86%, p = 0.034) and intensive care (12% vs 23%, p = 0.048). Median time to discharge was 6 days in the BNP group versus 10 days in the control group (p = 0.023). Total cost of treatment was $4,781 in the BNP group (95% confidence interval 3,854 to 5,708) versus $6,843 in the control group (95% confidence interval 5,611 to 8,074, p = 0.009). In-hospital mortality rates were 4% in the BNP group and 10% in the control group (p = 0.165). Thus, used in conjunction with other clinical information, rapid measurement of BNP decreased time to discharge and total cost of treatment in women who presented with acute dyspnea.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2004.08.029</identifier><identifier>PMID: 15589006</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Acute Disease ; Adult ; Aged ; Biological and medical sciences ; Biomarkers - blood ; Cardiology. Vascular system ; Comparative studies ; Critical Care - utilization ; Disease management ; Dyspnea - blood ; Dyspnea - economics ; Dyspnea - therapy ; Female ; Hospitalization ; Humans ; Length of Stay ; Male ; Medical diagnosis ; Medical sciences ; Medical treatment ; Middle Aged ; Natriuretic Peptide, Brain - blood ; Peptides ; Pneumology ; Prospective Studies ; Respiratory diseases ; Respiratory system : syndromes and miscellaneous diseases ; Women</subject><ispartof>The American journal of cardiology, 2004-12, Vol.94 (12), p.1510-1514</ispartof><rights>2004 Excerpta Medica Inc.</rights><rights>2005 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. Dec 15, 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-515868fcbf32ef630672d77dacb0c068f2962fafe13ba496a6d02a3beac8a84d3</citedby><cites>FETCH-LOGICAL-c420t-515868fcbf32ef630672d77dacb0c068f2962fafe13ba496a6d02a3beac8a84d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.amjcard.2004.08.029$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=16347464$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15589006$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mueller, Christian</creatorcontrib><creatorcontrib>Laule-Kilian, Kirsten</creatorcontrib><creatorcontrib>Scholer, André</creatorcontrib><creatorcontrib>Frana, Barbara</creatorcontrib><creatorcontrib>Rodriguez, Daniel</creatorcontrib><creatorcontrib>Schindler, Christian</creatorcontrib><creatorcontrib>Marsch, Stephan</creatorcontrib><creatorcontrib>Perruchoud, André P.</creatorcontrib><title>Use of B-type natriuretic peptide for the management of women with dyspnea</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>In studies with predominately male patients, B-type natriuretic peptide (BNP) levels have been shown to be helpful in the evaluation and management of patients who present with acute dyspnea. The effect of BNP levels on the management of women has not been defined. This study evaluated a predefined subgroup of 190 women included in a prospective randomized controlled study of BNP testing for emergency diagnosis of acute dyspnea. Patients were randomly assigned to a diagnostic strategy with (n = 93, BNP group) or without (n = 97, control group) the use of BNP levels provided by a rapid bedside assay. Women differed significantly from men in baseline characteristics, symptoms, signs, and final discharge diagnoses. The use of BNP levels decreased the need for hospital admission (73% vs 86%, p = 0.034) and intensive care (12% vs 23%, p = 0.048). Median time to discharge was 6 days in the BNP group versus 10 days in the control group (p = 0.023). Total cost of treatment was $4,781 in the BNP group (95% confidence interval 3,854 to 5,708) versus $6,843 in the control group (95% confidence interval 5,611 to 8,074, p = 0.009). In-hospital mortality rates were 4% in the BNP group and 10% in the control group (p = 0.165). Thus, used in conjunction with other clinical information, rapid measurement of BNP decreased time to discharge and total cost of treatment in women who presented with acute dyspnea.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Cardiology. Vascular system</subject><subject>Comparative studies</subject><subject>Critical Care - utilization</subject><subject>Disease management</subject><subject>Dyspnea - blood</subject><subject>Dyspnea - economics</subject><subject>Dyspnea - therapy</subject><subject>Female</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Length of Stay</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical sciences</subject><subject>Medical treatment</subject><subject>Middle Aged</subject><subject>Natriuretic Peptide, Brain - blood</subject><subject>Peptides</subject><subject>Pneumology</subject><subject>Prospective Studies</subject><subject>Respiratory diseases</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Women</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2LFDEQhoMo7uzqT1AaQW_dVpLudPdJdHH9YMGLew7VScXNMP1hknaZf2-GaVjw4qlS5HmLl4exVxwqDly931c47g0GWwmAuoKuAtE_YTvetX3Jey6fsh0AiLLndX_BLmPc55XzRj1nF7xpuh5A7dj3u0jF7IpPZTouVEyYgl8DJW-KhZbkLRVuDkW6p2LECX_RSFM6BR7m_CoefLov7DEuE-EL9szhIdLLbV6xu5vPP6-_lrc_vny7_nhbmlpAKhvedKpzZnBSkFMSVCts21o0AxjIP6JXwqEjLgese4XKgkA5EJoOu9rKK_bufHcJ8--VYtKjj4YOB5xoXqNWLVeikzyDb_4B9_MaptxNCwmykX1dZ6g5QybMMQZyegl-xHDUHPTJtN7rzbQ-mdbQ6Ww6515vx9dhJPuY2tRm4O0GYDR4cAEn4-Mjp2Td1upU4MOZo-zsj6ego_E0GbI-kEnazv4_Vf4CKcueLg</recordid><startdate>20041215</startdate><enddate>20041215</enddate><creator>Mueller, Christian</creator><creator>Laule-Kilian, Kirsten</creator><creator>Scholer, André</creator><creator>Frana, Barbara</creator><creator>Rodriguez, Daniel</creator><creator>Schindler, Christian</creator><creator>Marsch, Stephan</creator><creator>Perruchoud, André P.</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20041215</creationdate><title>Use of B-type natriuretic peptide for the management of women with dyspnea</title><author>Mueller, Christian ; Laule-Kilian, Kirsten ; Scholer, André ; Frana, Barbara ; Rodriguez, Daniel ; Schindler, Christian ; Marsch, Stephan ; Perruchoud, André P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-515868fcbf32ef630672d77dacb0c068f2962fafe13ba496a6d02a3beac8a84d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Cardiology. Vascular system</topic><topic>Comparative studies</topic><topic>Critical Care - utilization</topic><topic>Disease management</topic><topic>Dyspnea - blood</topic><topic>Dyspnea - economics</topic><topic>Dyspnea - therapy</topic><topic>Female</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Length of Stay</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medical sciences</topic><topic>Medical treatment</topic><topic>Middle Aged</topic><topic>Natriuretic Peptide, Brain - blood</topic><topic>Peptides</topic><topic>Pneumology</topic><topic>Prospective Studies</topic><topic>Respiratory diseases</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mueller, Christian</creatorcontrib><creatorcontrib>Laule-Kilian, Kirsten</creatorcontrib><creatorcontrib>Scholer, André</creatorcontrib><creatorcontrib>Frana, Barbara</creatorcontrib><creatorcontrib>Rodriguez, Daniel</creatorcontrib><creatorcontrib>Schindler, Christian</creatorcontrib><creatorcontrib>Marsch, Stephan</creatorcontrib><creatorcontrib>Perruchoud, André P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mueller, Christian</au><au>Laule-Kilian, Kirsten</au><au>Scholer, André</au><au>Frana, Barbara</au><au>Rodriguez, Daniel</au><au>Schindler, Christian</au><au>Marsch, Stephan</au><au>Perruchoud, André P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of B-type natriuretic peptide for the management of women with dyspnea</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2004-12-15</date><risdate>2004</risdate><volume>94</volume><issue>12</issue><spage>1510</spage><epage>1514</epage><pages>1510-1514</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>In studies with predominately male patients, B-type natriuretic peptide (BNP) levels have been shown to be helpful in the evaluation and management of patients who present with acute dyspnea. The effect of BNP levels on the management of women has not been defined. This study evaluated a predefined subgroup of 190 women included in a prospective randomized controlled study of BNP testing for emergency diagnosis of acute dyspnea. Patients were randomly assigned to a diagnostic strategy with (n = 93, BNP group) or without (n = 97, control group) the use of BNP levels provided by a rapid bedside assay. Women differed significantly from men in baseline characteristics, symptoms, signs, and final discharge diagnoses. The use of BNP levels decreased the need for hospital admission (73% vs 86%, p = 0.034) and intensive care (12% vs 23%, p = 0.048). Median time to discharge was 6 days in the BNP group versus 10 days in the control group (p = 0.023). Total cost of treatment was $4,781 in the BNP group (95% confidence interval 3,854 to 5,708) versus $6,843 in the control group (95% confidence interval 5,611 to 8,074, p = 0.009). In-hospital mortality rates were 4% in the BNP group and 10% in the control group (p = 0.165). Thus, used in conjunction with other clinical information, rapid measurement of BNP decreased time to discharge and total cost of treatment in women who presented with acute dyspnea.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15589006</pmid><doi>10.1016/j.amjcard.2004.08.029</doi><tpages>5</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0002-9149
ispartof The American journal of cardiology, 2004-12, Vol.94 (12), p.1510-1514
issn 0002-9149
1879-1913
language eng
recordid cdi_proquest_miscellaneous_67162831
source MEDLINE; Access via ScienceDirect (Elsevier)
subjects Acute Disease
Adult
Aged
Biological and medical sciences
Biomarkers - blood
Cardiology. Vascular system
Comparative studies
Critical Care - utilization
Disease management
Dyspnea - blood
Dyspnea - economics
Dyspnea - therapy
Female
Hospitalization
Humans
Length of Stay
Male
Medical diagnosis
Medical sciences
Medical treatment
Middle Aged
Natriuretic Peptide, Brain - blood
Peptides
Pneumology
Prospective Studies
Respiratory diseases
Respiratory system : syndromes and miscellaneous diseases
Women
title Use of B-type natriuretic peptide for the management of women with dyspnea
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T07%3A54%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Use%20of%20B-type%20natriuretic%20peptide%20for%20the%20management%20of%20women%20with%20dyspnea&rft.jtitle=The%20American%20journal%20of%20cardiology&rft.au=Mueller,%20Christian&rft.date=2004-12-15&rft.volume=94&rft.issue=12&rft.spage=1510&rft.epage=1514&rft.pages=1510-1514&rft.issn=0002-9149&rft.eissn=1879-1913&rft.coden=AJCDAG&rft_id=info:doi/10.1016/j.amjcard.2004.08.029&rft_dat=%3Cproquest_cross%3E67162831%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=230353944&rft_id=info:pmid/15589006&rft_els_id=S0002914904013797&rfr_iscdi=true