Biochemical and kinetic characterization of BACE1: investigation into the putative species‐specificity for β‐ and β′‐cleavage sites by human and murine BACE1

β‐amyloid peptides (Aβ) are produced by a sequential cleavage of amyloid precursor protein (APP) by β‐ and γ‐secretases. The lack of Aβ production in beta‐APP cleaving enzyme (BACE1)–/– mice suggests that BACE1 is the principal β‐secretase in mammalian neurons. Transfection of human APP and BACE1 in...

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Veröffentlicht in:Journal of neurochemistry 2004-12, Vol.91 (6), p.1249-1259
Hauptverfasser: Yang, Hsiu‐Chiung, Chai, Xiyun, Mosior, Marian, Kohn, Wayne, Boggs, Leonard N., Erickson, Jon A., McClure, Don B., Yeh, Wu‐Kuang, Zhang, Lianshen, Gonzalez‐DeWhitt, Patricia, Mayer, John P., Martin, Jose Alfredo, Hu, Jingdan, Chen, Shu‐hui, Bueno, Ana Belen, Little, Sheila P., McCarthy, James R., May, Patrick C.
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Sprache:eng
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