A Phage Display System with Unnatural Amino Acids

We report a general method to display peptide-containing unnatural amino acids on filamentous M13 phage. Five distinct unnatural amino acids were site-specifically incorporated at the N-terminal of the M13 phage minor coat protein pIII. Phages that contain p-azidophenylalanine can undergo a highly s...

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Veröffentlicht in:	Journal of the American Chemical Society 2004-12, Vol.126 (49), p.15962-15963
Hauptverfasser:	Tian, Feng, Tsao, Meng-Lin, Schultz, Peter G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - genetics Amino Acids - metabolism Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Biological and medical sciences Capsid Proteins Carrier Proteins - genetics Carrier Proteins - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Fundamental and applied biological sciences. Psychology Methanococcus - genetics Methanococcus - metabolism Peptide Biosynthesis - genetics Peptide Library Proteins Viral Fusion Proteins - genetics Viral Fusion Proteins - metabolism
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