Polymorphonuclear Neutrophil Infiltration Intensity as Consequence of Entamoeba histolytica Density in Amebic Colitis
Background: It has been suggested that the damage observed in invasive amebiasis is related to interactions between polymorphonuclear leukocytes (PMN) and Entamoeba histolytica trophozoites. We analyzed the relation between infiltrating inflammatory cell populations and E. histolytica density in int...
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| Veröffentlicht in: | Surgical infections 2009-04, Vol.10 (2), p.91-97 |
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| creator | Dickson-Gonzalez, Sonia M. de Uribe, Marleny Lunar Rodriguez-Morales, Alfonso J. |
| description | Background:
It has been suggested that the damage observed in invasive amebiasis is related to interactions between polymorphonuclear leukocytes (PMN) and
Entamoeba histolytica
trophozoites. We analyzed the relation between infiltrating inflammatory cell populations and
E. histolytica
density in intestinal amebic lesions.
Methods:
Biopsies obtained endoscopically from patients with amebic colitis were analyzed to describe their morphologic abnormalities. Cellular populations and
E. histolytica
trophozoites were measured quantitatively in order to assess the correlation between infiltrating inflammatory cell populations and parasite density.
Results:
Amebic lesions were most often located in the colon (55%). The histopathologic diagnoses were colitis in 31%, erosive colitis in 26%, and ulcerated colitis in 24%. The predominant cellular populations found in the lesions were lymphocytes (59.8%) (3,672 ± 2,413/mm
2
) followed by PMN (17%) (1,038 ± 1,171 PMN/mm
2
) (p < 0.01). A higher density of PMN infiltration was observed in severe cases. Cellular populations predictive of the presence of
E. histolytica
trophozoites (p = 0.047) were PMN (p = 0.019) and lymphocytes (p = 0.033). The highest association was found between
E. histolytica
trophozoites and PMN (p = 0.0221).
Conclusions:
Neutrophils and lymphocytes, particularly the former, are associated significantly with the density of parasites. Our findings support the theory that PMN interaction with
E. histolytica
contributes to the pathogenesis of amebic intestinal lesions. |
| doi_str_mv | 10.1089/sur.2008.011 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_67160214</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A207113718</galeid><sourcerecordid>A207113718</sourcerecordid><originalsourceid>FETCH-LOGICAL-c391t-75c06a725e05ec94d70e8021f199ba18ccdc5b734a85a8f860323432bb2cb10c3</originalsourceid><addsrcrecordid>eNptkc2LFDEQxYMo7pc3zxIQPCz2bCrdnaSPw7jqwqIe9BzSmWonkk7GJH2Y_94MMygLkkNS4fceVfUIeQ1sBUwNd3lJK86YWjGAZ-QS-l42SsjueX2zQTR8EN0Fucr5F2MguRAvyQUo1YJQ7JIs36I_zDHtdzEs1qNJ9AsuJcX9znn6ECbnSzLFxVCLgiG7cqAm000MGX8vGCzSONH7UMwccTR053KplsVZQz-ceRfoesbR2Srzrrh8Q15Mxmd8db6vyY-P9983n5vHr58eNuvHxrYDlEb2lgkjeY-sRzt0W8lQMQ4TDMNoQFm7tf0o286o3qhJCdbytmv5OHI7ArPtNXl38t2nWJvNRc8uW_TeBIxL1kKCqH5dBd-ewJ_Go3ZhinVqe4T1mjMJ0EpQlVr9h6pni7OzMWDdFj4VvD8JbIo5J5z0PrnZpIMGpo_p6ZqePqana3oVf3Nudxln3P6Dz3FV4PYEHL9NCN7hiKn8BZ-4_QHS-6V3</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67160214</pqid></control><display><type>article</type><title>Polymorphonuclear Neutrophil Infiltration Intensity as Consequence of Entamoeba histolytica Density in Amebic Colitis</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Dickson-Gonzalez, Sonia M. ; de Uribe, Marleny Lunar ; Rodriguez-Morales, Alfonso J.</creator><creatorcontrib>Dickson-Gonzalez, Sonia M. ; de Uribe, Marleny Lunar ; Rodriguez-Morales, Alfonso J.</creatorcontrib><description>Background:
It has been suggested that the damage observed in invasive amebiasis is related to interactions between polymorphonuclear leukocytes (PMN) and
Entamoeba histolytica
trophozoites. We analyzed the relation between infiltrating inflammatory cell populations and
E. histolytica
density in intestinal amebic lesions.
Methods:
Biopsies obtained endoscopically from patients with amebic colitis were analyzed to describe their morphologic abnormalities. Cellular populations and
E. histolytica
trophozoites were measured quantitatively in order to assess the correlation between infiltrating inflammatory cell populations and parasite density.
Results:
Amebic lesions were most often located in the colon (55%). The histopathologic diagnoses were colitis in 31%, erosive colitis in 26%, and ulcerated colitis in 24%. The predominant cellular populations found in the lesions were lymphocytes (59.8%) (3,672 ± 2,413/mm
2
) followed by PMN (17%) (1,038 ± 1,171 PMN/mm
2
) (p < 0.01). A higher density of PMN infiltration was observed in severe cases. Cellular populations predictive of the presence of
E. histolytica
trophozoites (p = 0.047) were PMN (p = 0.019) and lymphocytes (p = 0.033). The highest association was found between
E. histolytica
trophozoites and PMN (p = 0.0221).
Conclusions:
Neutrophils and lymphocytes, particularly the former, are associated significantly with the density of parasites. Our findings support the theory that PMN interaction with
E. histolytica
contributes to the pathogenesis of amebic intestinal lesions.</description><identifier>ISSN: 1096-2964</identifier><identifier>EISSN: 1557-8674</identifier><identifier>DOI: 10.1089/sur.2008.011</identifier><identifier>PMID: 18831680</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Amebiasis ; Analysis of Variance ; Animals ; Causes of ; Cell Count ; Chi-Square Distribution ; Child ; Child, Preschool ; Colon - parasitology ; Colon - ultrastructure ; Development and progression ; Dysentery, Amebic - immunology ; Dysentery, Amebic - parasitology ; Dysentery, Amebic - pathology ; Entamoeba histolytica - immunology ; Female ; Humans ; Infant ; Intestinal Mucosa - parasitology ; Intestinal Mucosa - ultrastructure ; Intestine, Large - parasitology ; Intestine, Large - pathology ; Linear Models ; Lymphocytes ; Lymphocytes - immunology ; Male ; Middle Aged ; Neutrophil Infiltration ; Neutrophils ; Neutrophils - immunology ; ORIGINAL PAPERS ; Physiological aspects ; Trophozoites - immunology</subject><ispartof>Surgical infections, 2009-04, Vol.10 (2), p.91-97</ispartof><rights>2009 Mary Ann Liebert, Inc.</rights><rights>COPYRIGHT 2009 Mary Ann Liebert, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-75c06a725e05ec94d70e8021f199ba18ccdc5b734a85a8f860323432bb2cb10c3</citedby><cites>FETCH-LOGICAL-c391t-75c06a725e05ec94d70e8021f199ba18ccdc5b734a85a8f860323432bb2cb10c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18831680$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dickson-Gonzalez, Sonia M.</creatorcontrib><creatorcontrib>de Uribe, Marleny Lunar</creatorcontrib><creatorcontrib>Rodriguez-Morales, Alfonso J.</creatorcontrib><title>Polymorphonuclear Neutrophil Infiltration Intensity as Consequence of Entamoeba histolytica Density in Amebic Colitis</title><title>Surgical infections</title><addtitle>Surg Infect (Larchmt)</addtitle><description>Background:
It has been suggested that the damage observed in invasive amebiasis is related to interactions between polymorphonuclear leukocytes (PMN) and
Entamoeba histolytica
trophozoites. We analyzed the relation between infiltrating inflammatory cell populations and
E. histolytica
density in intestinal amebic lesions.
Methods:
Biopsies obtained endoscopically from patients with amebic colitis were analyzed to describe their morphologic abnormalities. Cellular populations and
E. histolytica
trophozoites were measured quantitatively in order to assess the correlation between infiltrating inflammatory cell populations and parasite density.
Results:
Amebic lesions were most often located in the colon (55%). The histopathologic diagnoses were colitis in 31%, erosive colitis in 26%, and ulcerated colitis in 24%. The predominant cellular populations found in the lesions were lymphocytes (59.8%) (3,672 ± 2,413/mm
2
) followed by PMN (17%) (1,038 ± 1,171 PMN/mm
2
) (p < 0.01). A higher density of PMN infiltration was observed in severe cases. Cellular populations predictive of the presence of
E. histolytica
trophozoites (p = 0.047) were PMN (p = 0.019) and lymphocytes (p = 0.033). The highest association was found between
E. histolytica
trophozoites and PMN (p = 0.0221).
Conclusions:
Neutrophils and lymphocytes, particularly the former, are associated significantly with the density of parasites. Our findings support the theory that PMN interaction with
E. histolytica
contributes to the pathogenesis of amebic intestinal lesions.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amebiasis</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Causes of</subject><subject>Cell Count</subject><subject>Chi-Square Distribution</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Colon - parasitology</subject><subject>Colon - ultrastructure</subject><subject>Development and progression</subject><subject>Dysentery, Amebic - immunology</subject><subject>Dysentery, Amebic - parasitology</subject><subject>Dysentery, Amebic - pathology</subject><subject>Entamoeba histolytica - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Intestinal Mucosa - parasitology</subject><subject>Intestinal Mucosa - ultrastructure</subject><subject>Intestine, Large - parasitology</subject><subject>Intestine, Large - pathology</subject><subject>Linear Models</subject><subject>Lymphocytes</subject><subject>Lymphocytes - immunology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neutrophil Infiltration</subject><subject>Neutrophils</subject><subject>Neutrophils - immunology</subject><subject>ORIGINAL PAPERS</subject><subject>Physiological aspects</subject><subject>Trophozoites - immunology</subject><issn>1096-2964</issn><issn>1557-8674</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkc2LFDEQxYMo7pc3zxIQPCz2bCrdnaSPw7jqwqIe9BzSmWonkk7GJH2Y_94MMygLkkNS4fceVfUIeQ1sBUwNd3lJK86YWjGAZ-QS-l42SsjueX2zQTR8EN0Fucr5F2MguRAvyQUo1YJQ7JIs36I_zDHtdzEs1qNJ9AsuJcX9znn6ECbnSzLFxVCLgiG7cqAm000MGX8vGCzSONH7UMwccTR053KplsVZQz-ceRfoesbR2Srzrrh8Q15Mxmd8db6vyY-P9983n5vHr58eNuvHxrYDlEb2lgkjeY-sRzt0W8lQMQ4TDMNoQFm7tf0o286o3qhJCdbytmv5OHI7ArPtNXl38t2nWJvNRc8uW_TeBIxL1kKCqH5dBd-ewJ_Go3ZhinVqe4T1mjMJ0EpQlVr9h6pni7OzMWDdFj4VvD8JbIo5J5z0PrnZpIMGpo_p6ZqePqana3oVf3Nudxln3P6Dz3FV4PYEHL9NCN7hiKn8BZ-4_QHS-6V3</recordid><startdate>20090401</startdate><enddate>20090401</enddate><creator>Dickson-Gonzalez, Sonia M.</creator><creator>de Uribe, Marleny Lunar</creator><creator>Rodriguez-Morales, Alfonso J.</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090401</creationdate><title>Polymorphonuclear Neutrophil Infiltration Intensity as Consequence of Entamoeba histolytica Density in Amebic Colitis</title><author>Dickson-Gonzalez, Sonia M. ; de Uribe, Marleny Lunar ; Rodriguez-Morales, Alfonso J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-75c06a725e05ec94d70e8021f199ba18ccdc5b734a85a8f860323432bb2cb10c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Amebiasis</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Causes of</topic><topic>Cell Count</topic><topic>Chi-Square Distribution</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Colon - parasitology</topic><topic>Colon - ultrastructure</topic><topic>Development and progression</topic><topic>Dysentery, Amebic - immunology</topic><topic>Dysentery, Amebic - parasitology</topic><topic>Dysentery, Amebic - pathology</topic><topic>Entamoeba histolytica - immunology</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Intestinal Mucosa - parasitology</topic><topic>Intestinal Mucosa - ultrastructure</topic><topic>Intestine, Large - parasitology</topic><topic>Intestine, Large - pathology</topic><topic>Linear Models</topic><topic>Lymphocytes</topic><topic>Lymphocytes - immunology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neutrophil Infiltration</topic><topic>Neutrophils</topic><topic>Neutrophils - immunology</topic><topic>ORIGINAL PAPERS</topic><topic>Physiological aspects</topic><topic>Trophozoites - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dickson-Gonzalez, Sonia M.</creatorcontrib><creatorcontrib>de Uribe, Marleny Lunar</creatorcontrib><creatorcontrib>Rodriguez-Morales, Alfonso J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgical infections</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dickson-Gonzalez, Sonia M.</au><au>de Uribe, Marleny Lunar</au><au>Rodriguez-Morales, Alfonso J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphonuclear Neutrophil Infiltration Intensity as Consequence of Entamoeba histolytica Density in Amebic Colitis</atitle><jtitle>Surgical infections</jtitle><addtitle>Surg Infect (Larchmt)</addtitle><date>2009-04-01</date><risdate>2009</risdate><volume>10</volume><issue>2</issue><spage>91</spage><epage>97</epage><pages>91-97</pages><issn>1096-2964</issn><eissn>1557-8674</eissn><abstract>Background:
It has been suggested that the damage observed in invasive amebiasis is related to interactions between polymorphonuclear leukocytes (PMN) and
Entamoeba histolytica
trophozoites. We analyzed the relation between infiltrating inflammatory cell populations and
E. histolytica
density in intestinal amebic lesions.
Methods:
Biopsies obtained endoscopically from patients with amebic colitis were analyzed to describe their morphologic abnormalities. Cellular populations and
E. histolytica
trophozoites were measured quantitatively in order to assess the correlation between infiltrating inflammatory cell populations and parasite density.
Results:
Amebic lesions were most often located in the colon (55%). The histopathologic diagnoses were colitis in 31%, erosive colitis in 26%, and ulcerated colitis in 24%. The predominant cellular populations found in the lesions were lymphocytes (59.8%) (3,672 ± 2,413/mm
2
) followed by PMN (17%) (1,038 ± 1,171 PMN/mm
2
) (p < 0.01). A higher density of PMN infiltration was observed in severe cases. Cellular populations predictive of the presence of
E. histolytica
trophozoites (p = 0.047) were PMN (p = 0.019) and lymphocytes (p = 0.033). The highest association was found between
E. histolytica
trophozoites and PMN (p = 0.0221).
Conclusions:
Neutrophils and lymphocytes, particularly the former, are associated significantly with the density of parasites. Our findings support the theory that PMN interaction with
E. histolytica
contributes to the pathogenesis of amebic intestinal lesions.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>18831680</pmid><doi>10.1089/sur.2008.011</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Surgical infections, 2009-04, Vol.10 (2), p.91-97 |
| issn | 1096-2964 1557-8674 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67160214 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Aged, 80 and over Amebiasis Analysis of Variance Animals Causes of Cell Count Chi-Square Distribution Child Child, Preschool Colon - parasitology Colon - ultrastructure Development and progression Dysentery, Amebic - immunology Dysentery, Amebic - parasitology Dysentery, Amebic - pathology Entamoeba histolytica - immunology Female Humans Infant Intestinal Mucosa - parasitology Intestinal Mucosa - ultrastructure Intestine, Large - parasitology Intestine, Large - pathology Linear Models Lymphocytes Lymphocytes - immunology Male Middle Aged Neutrophil Infiltration Neutrophils Neutrophils - immunology ORIGINAL PAPERS Physiological aspects Trophozoites - immunology |
| title | Polymorphonuclear Neutrophil Infiltration Intensity as Consequence of Entamoeba histolytica Density in Amebic Colitis |
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