Central corneal thickness of Caucasians, Chinese, Hispanics, Filipinos, African Americans, and Japanese in a glaucoma clinic
To characterize the central corneal thickness (CCT) of Asian (Chinese, Japanese, and Filipino), Caucasian, Hispanic, and African American patients in a multiethnic glaucoma practice. Retrospective study (chart review). Glaucomatous (n = 600) and nonglaucomatous (n = 201) eyes of 801 patients examine...
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| creator | Aghaian, Elsa Choe, Joyce E. Lin, Shan Stamper, Robert L. |
| description | To characterize the central corneal thickness (CCT) of Asian (Chinese, Japanese, and Filipino), Caucasian, Hispanic, and African American patients in a multiethnic glaucoma practice.
Retrospective study (chart review).
Glaucomatous (n = 600) and nonglaucomatous (n = 201) eyes of 801 patients examined in a San Francisco glaucoma clinic from June 2002 to April 2004 who met inclusion criteria were included in the study. The 6 racial (ethnic) groups represented in the study were Caucasian (n = 186, 23.2%), Chinese (n = 157, 19.6%), Japanese (n = 121, 15.1%), Hispanic (n = 116, 14.5%), Filipino (n = 114, 14.2%), and African American (n = 107, 13.4%).
Central corneal thickness was measured by means of ultrasound pachymetry in Asian (Chinese, Japanese, and Filipino), Caucasian, Hispanic, and African American participants with glaucomatous and normal eyes. The relationship between CCT and race was investigated using multivariate regression analyses, controlling for confounders. One eye of each of 801 participants was included for analysis.
Correlation of mean CCT with race, glaucoma diagnosis, age, spherical equivalent, gender, and history of ocular surgery.
The mean CCT of all participants was 542.9 μm. Central corneal thicknesses of Chinese (555.6 μm), Caucasian (550.4 μm), Filipino (550.6 μm), and Hispanic (548.1 μm) participants did not significantly differ. The CCT of Japanese participants (531.7 μm) was significantly less than that ofCaucasians, Chinese, Filipinos, and Hispanics (all,
P≤0.001) and greater than that of African Americans (
P = 0.03). African Americans had a CCT (521.0.0 μm) less than that of all races (
P≤0.05). Glaucoma suspects and patients with normal tension glaucoma (NTG), primary open-angle glaucoma (POAG), pseudoexfoliation glaucoma (PEX), and chronic angle-closure glaucoma (CACG) had corneas significantly thinner than those of normal participants (
P≤0.004), whereas ocular hypertensives had significantly thicker corneas (
P |
| doi_str_mv | 10.1016/j.ophtha.2004.06.013 |
| format | Article |
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Retrospective study (chart review).
Glaucomatous (n = 600) and nonglaucomatous (n = 201) eyes of 801 patients examined in a San Francisco glaucoma clinic from June 2002 to April 2004 who met inclusion criteria were included in the study. The 6 racial (ethnic) groups represented in the study were Caucasian (n = 186, 23.2%), Chinese (n = 157, 19.6%), Japanese (n = 121, 15.1%), Hispanic (n = 116, 14.5%), Filipino (n = 114, 14.2%), and African American (n = 107, 13.4%).
Central corneal thickness was measured by means of ultrasound pachymetry in Asian (Chinese, Japanese, and Filipino), Caucasian, Hispanic, and African American participants with glaucomatous and normal eyes. The relationship between CCT and race was investigated using multivariate regression analyses, controlling for confounders. One eye of each of 801 participants was included for analysis.
Correlation of mean CCT with race, glaucoma diagnosis, age, spherical equivalent, gender, and history of ocular surgery.
The mean CCT of all participants was 542.9 μm. Central corneal thicknesses of Chinese (555.6 μm), Caucasian (550.4 μm), Filipino (550.6 μm), and Hispanic (548.1 μm) participants did not significantly differ. The CCT of Japanese participants (531.7 μm) was significantly less than that ofCaucasians, Chinese, Filipinos, and Hispanics (all,
P≤0.001) and greater than that of African Americans (
P = 0.03). African Americans had a CCT (521.0.0 μm) less than that of all races (
P≤0.05). Glaucoma suspects and patients with normal tension glaucoma (NTG), primary open-angle glaucoma (POAG), pseudoexfoliation glaucoma (PEX), and chronic angle-closure glaucoma (CACG) had corneas significantly thinner than those of normal participants (
P≤0.004), whereas ocular hypertensives had significantly thicker corneas (
P<0.0001). Among all participants, decreasing values of CCT were significantly related to older age (
P<0.01). Less negative or more positive refractive errors, gender, and history of ocular surgery were not associated with changes in CCT (
P = 0.38,
P = 0.50, and
P = 0.97, respectively).
Studies examining individual Asian subpopulations in isolation suggest that differences in CCT may exist among different Asian groups. The results of this study indicate that CCT does, in fact, vary among Asian subpopulations; Japanese have thinner corneas than Chinese and Filipinos. Caucasians, Chinese, Hispanics, and Filipinos have comparable CCT measurements, whereas the corneas of African Americans are significantly thinner. Additionally, older individuals; glaucoma suspects; and participants with NTG, POAG, PEX, and CACG have thinner corneas. Ocular hypertensives, however, have thicker corneas.</description><identifier>ISSN: 0161-6420</identifier><identifier>EISSN: 1549-4713</identifier><identifier>DOI: 10.1016/j.ophtha.2004.06.013</identifier><identifier>PMID: 15582076</identifier><identifier>CODEN: OPHTDG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; African Americans - ethnology ; African Continental Ancestry Group - ethnology ; Aged ; Asian Continental Ancestry Group - ethnology ; Biological and medical sciences ; Cornea - diagnostic imaging ; Cornea - pathology ; Diagnostic Techniques, Ophthalmological ; Diseases of cornea, anterior segment and sclera ; European Continental Ancestry Group - ethnology ; Female ; Glaucoma - ethnology ; Glaucoma and intraocular pressure ; Hispanic Americans - ethnology ; Humans ; Male ; Medical sciences ; Middle Aged ; Ophthalmology ; Philippines - ethnology ; Retrospective Studies ; Ultrasonography</subject><ispartof>Ophthalmology (Rochester, Minn.), 2004-12, Vol.111 (12), p.2211-2219</ispartof><rights>2004 American Academy of Ophthalmology</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-56c04ff374b8be09430b1f1271e2158a9f34ada54fd1dc17c83e5f3e91505b4d3</citedby><cites>FETCH-LOGICAL-c454t-56c04ff374b8be09430b1f1271e2158a9f34ada54fd1dc17c83e5f3e91505b4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ophtha.2004.06.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16338342$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15582076$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aghaian, Elsa</creatorcontrib><creatorcontrib>Choe, Joyce E.</creatorcontrib><creatorcontrib>Lin, Shan</creatorcontrib><creatorcontrib>Stamper, Robert L.</creatorcontrib><title>Central corneal thickness of Caucasians, Chinese, Hispanics, Filipinos, African Americans, and Japanese in a glaucoma clinic</title><title>Ophthalmology (Rochester, Minn.)</title><addtitle>Ophthalmology</addtitle><description>To characterize the central corneal thickness (CCT) of Asian (Chinese, Japanese, and Filipino), Caucasian, Hispanic, and African American patients in a multiethnic glaucoma practice.
Retrospective study (chart review).
Glaucomatous (n = 600) and nonglaucomatous (n = 201) eyes of 801 patients examined in a San Francisco glaucoma clinic from June 2002 to April 2004 who met inclusion criteria were included in the study. The 6 racial (ethnic) groups represented in the study were Caucasian (n = 186, 23.2%), Chinese (n = 157, 19.6%), Japanese (n = 121, 15.1%), Hispanic (n = 116, 14.5%), Filipino (n = 114, 14.2%), and African American (n = 107, 13.4%).
Central corneal thickness was measured by means of ultrasound pachymetry in Asian (Chinese, Japanese, and Filipino), Caucasian, Hispanic, and African American participants with glaucomatous and normal eyes. The relationship between CCT and race was investigated using multivariate regression analyses, controlling for confounders. One eye of each of 801 participants was included for analysis.
Correlation of mean CCT with race, glaucoma diagnosis, age, spherical equivalent, gender, and history of ocular surgery.
The mean CCT of all participants was 542.9 μm. Central corneal thicknesses of Chinese (555.6 μm), Caucasian (550.4 μm), Filipino (550.6 μm), and Hispanic (548.1 μm) participants did not significantly differ. The CCT of Japanese participants (531.7 μm) was significantly less than that ofCaucasians, Chinese, Filipinos, and Hispanics (all,
P≤0.001) and greater than that of African Americans (
P = 0.03). African Americans had a CCT (521.0.0 μm) less than that of all races (
P≤0.05). Glaucoma suspects and patients with normal tension glaucoma (NTG), primary open-angle glaucoma (POAG), pseudoexfoliation glaucoma (PEX), and chronic angle-closure glaucoma (CACG) had corneas significantly thinner than those of normal participants (
P≤0.004), whereas ocular hypertensives had significantly thicker corneas (
P<0.0001). Among all participants, decreasing values of CCT were significantly related to older age (
P<0.01). Less negative or more positive refractive errors, gender, and history of ocular surgery were not associated with changes in CCT (
P = 0.38,
P = 0.50, and
P = 0.97, respectively).
Studies examining individual Asian subpopulations in isolation suggest that differences in CCT may exist among different Asian groups. The results of this study indicate that CCT does, in fact, vary among Asian subpopulations; Japanese have thinner corneas than Chinese and Filipinos. Caucasians, Chinese, Hispanics, and Filipinos have comparable CCT measurements, whereas the corneas of African Americans are significantly thinner. Additionally, older individuals; glaucoma suspects; and participants with NTG, POAG, PEX, and CACG have thinner corneas. Ocular hypertensives, however, have thicker corneas.</description><subject>Adult</subject><subject>African Americans - ethnology</subject><subject>African Continental Ancestry Group - ethnology</subject><subject>Aged</subject><subject>Asian Continental Ancestry Group - ethnology</subject><subject>Biological and medical sciences</subject><subject>Cornea - diagnostic imaging</subject><subject>Cornea - pathology</subject><subject>Diagnostic Techniques, Ophthalmological</subject><subject>Diseases of cornea, anterior segment and sclera</subject><subject>European Continental Ancestry Group - ethnology</subject><subject>Female</subject><subject>Glaucoma - ethnology</subject><subject>Glaucoma and intraocular pressure</subject><subject>Hispanic Americans - ethnology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Ophthalmology</subject><subject>Philippines - ethnology</subject><subject>Retrospective Studies</subject><subject>Ultrasonography</subject><issn>0161-6420</issn><issn>1549-4713</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVpaLZp_0EpurSn2NFYH7YvhcU0SUsgl_YsZHnU1daWXclbCOTHV8ku5NbTDMPzvgwPIR-AlcBAXe3LedmtO1NWjImSqZIBf0U2IEVbiBr4a7LJGBRKVOycvE1pzxhTios35BykbCpWqw157DCs0YzUzjFgnuvO298BU6Kzo505WJO8CemSdjufz3hJb31aTPA236796Bcf5rxuXfTWBLqd8HnJJxMG-t1kNseoD9TQX2MunCdD7ehzwzty5syY8P1pXpCf119_dLfF3f3Nt257V1ghxVpIZZlwjteib3pkreCsBwdVDViBbEzruDCDkcINMFiobcNROo4tSCZ7MfAL8vnYu8T5zwHTqiefLI5jfm0-JK1qkC2AzKA4gjbOKUV0eol-MvFBA9NP1vVeH63rJ-uaKZ2t59jHU_-hn3B4CZ00Z-DTCTDJmtFFE6xPL5zivOGiytyXI4fZxl-PUSfrMVgcfES76mH2___kH8iUokg</recordid><startdate>20041201</startdate><enddate>20041201</enddate><creator>Aghaian, Elsa</creator><creator>Choe, Joyce E.</creator><creator>Lin, Shan</creator><creator>Stamper, Robert L.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041201</creationdate><title>Central corneal thickness of Caucasians, Chinese, Hispanics, Filipinos, African Americans, and Japanese in a glaucoma clinic</title><author>Aghaian, Elsa ; Choe, Joyce E. ; Lin, Shan ; Stamper, Robert L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-56c04ff374b8be09430b1f1271e2158a9f34ada54fd1dc17c83e5f3e91505b4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>African Americans - ethnology</topic><topic>African Continental Ancestry Group - ethnology</topic><topic>Aged</topic><topic>Asian Continental Ancestry Group - ethnology</topic><topic>Biological and medical sciences</topic><topic>Cornea - diagnostic imaging</topic><topic>Cornea - pathology</topic><topic>Diagnostic Techniques, Ophthalmological</topic><topic>Diseases of cornea, anterior segment and sclera</topic><topic>European Continental Ancestry Group - ethnology</topic><topic>Female</topic><topic>Glaucoma - ethnology</topic><topic>Glaucoma and intraocular pressure</topic><topic>Hispanic Americans - ethnology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Ophthalmology</topic><topic>Philippines - ethnology</topic><topic>Retrospective Studies</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aghaian, Elsa</creatorcontrib><creatorcontrib>Choe, Joyce E.</creatorcontrib><creatorcontrib>Lin, Shan</creatorcontrib><creatorcontrib>Stamper, Robert L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ophthalmology (Rochester, Minn.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aghaian, Elsa</au><au>Choe, Joyce E.</au><au>Lin, Shan</au><au>Stamper, Robert L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Central corneal thickness of Caucasians, Chinese, Hispanics, Filipinos, African Americans, and Japanese in a glaucoma clinic</atitle><jtitle>Ophthalmology (Rochester, Minn.)</jtitle><addtitle>Ophthalmology</addtitle><date>2004-12-01</date><risdate>2004</risdate><volume>111</volume><issue>12</issue><spage>2211</spage><epage>2219</epage><pages>2211-2219</pages><issn>0161-6420</issn><eissn>1549-4713</eissn><coden>OPHTDG</coden><abstract>To characterize the central corneal thickness (CCT) of Asian (Chinese, Japanese, and Filipino), Caucasian, Hispanic, and African American patients in a multiethnic glaucoma practice.
Retrospective study (chart review).
Glaucomatous (n = 600) and nonglaucomatous (n = 201) eyes of 801 patients examined in a San Francisco glaucoma clinic from June 2002 to April 2004 who met inclusion criteria were included in the study. The 6 racial (ethnic) groups represented in the study were Caucasian (n = 186, 23.2%), Chinese (n = 157, 19.6%), Japanese (n = 121, 15.1%), Hispanic (n = 116, 14.5%), Filipino (n = 114, 14.2%), and African American (n = 107, 13.4%).
Central corneal thickness was measured by means of ultrasound pachymetry in Asian (Chinese, Japanese, and Filipino), Caucasian, Hispanic, and African American participants with glaucomatous and normal eyes. The relationship between CCT and race was investigated using multivariate regression analyses, controlling for confounders. One eye of each of 801 participants was included for analysis.
Correlation of mean CCT with race, glaucoma diagnosis, age, spherical equivalent, gender, and history of ocular surgery.
The mean CCT of all participants was 542.9 μm. Central corneal thicknesses of Chinese (555.6 μm), Caucasian (550.4 μm), Filipino (550.6 μm), and Hispanic (548.1 μm) participants did not significantly differ. The CCT of Japanese participants (531.7 μm) was significantly less than that ofCaucasians, Chinese, Filipinos, and Hispanics (all,
P≤0.001) and greater than that of African Americans (
P = 0.03). African Americans had a CCT (521.0.0 μm) less than that of all races (
P≤0.05). Glaucoma suspects and patients with normal tension glaucoma (NTG), primary open-angle glaucoma (POAG), pseudoexfoliation glaucoma (PEX), and chronic angle-closure glaucoma (CACG) had corneas significantly thinner than those of normal participants (
P≤0.004), whereas ocular hypertensives had significantly thicker corneas (
P<0.0001). Among all participants, decreasing values of CCT were significantly related to older age (
P<0.01). Less negative or more positive refractive errors, gender, and history of ocular surgery were not associated with changes in CCT (
P = 0.38,
P = 0.50, and
P = 0.97, respectively).
Studies examining individual Asian subpopulations in isolation suggest that differences in CCT may exist among different Asian groups. The results of this study indicate that CCT does, in fact, vary among Asian subpopulations; Japanese have thinner corneas than Chinese and Filipinos. Caucasians, Chinese, Hispanics, and Filipinos have comparable CCT measurements, whereas the corneas of African Americans are significantly thinner. Additionally, older individuals; glaucoma suspects; and participants with NTG, POAG, PEX, and CACG have thinner corneas. Ocular hypertensives, however, have thicker corneas.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15582076</pmid><doi>10.1016/j.ophtha.2004.06.013</doi><tpages>9</tpages></addata></record> |
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| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Adult African Americans - ethnology African Continental Ancestry Group - ethnology Aged Asian Continental Ancestry Group - ethnology Biological and medical sciences Cornea - diagnostic imaging Cornea - pathology Diagnostic Techniques, Ophthalmological Diseases of cornea, anterior segment and sclera European Continental Ancestry Group - ethnology Female Glaucoma - ethnology Glaucoma and intraocular pressure Hispanic Americans - ethnology Humans Male Medical sciences Middle Aged Ophthalmology Philippines - ethnology Retrospective Studies Ultrasonography |
| title | Central corneal thickness of Caucasians, Chinese, Hispanics, Filipinos, African Americans, and Japanese in a glaucoma clinic |
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