The Structure of Sox17 Bound to DNA Reveals a Conserved Bending Topology but Selective Protein Interaction Platforms

Sox17 regulates endodermal lineage commitment and is thought to function antagonistically to the pluripotency determinant Sox2. To investigate the biochemical basis for the distinct functions of Sox2 and Sox17, we solved the crystal structure of the high mobility group domain of Sox17 bound to a DNA...

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Veröffentlicht in:Journal of molecular biology 2009-05, Vol.388 (3), p.619-630
Hauptverfasser: Palasingam, Paaventhan, Jauch, Ralf, Ng, Calista Keow Leng, Kolatkar, Prasanna R.
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Sprache:eng
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